Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Iris Pecker"'
Autor:
Ewa Cendrowicz, Lisa Jacob, Shirley Greenwald, Ami Tamir, Iris Pecker, Rinat Tabakman, Lucy Ghantous, Liat Tamir, Roy Kahn, Jasmine Avichzer, Alexandra Aronin, Shira Amsili, Elina Zorde-Khvalevsky, Yosi Gozlan, Martijn Vlaming, Gerwin Huls, Tom van Meerten, Michal Elhalel Dranitzki, Adam Foley-Comer, Yaron Pereg, Amnon Peled, Ayelet Chajut, Edwin Bremer
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Treatment of Diffuse Large B Cell Lymphoma (DLBCL) patients with rituximab and the CHOP treatment regimen is associated with frequent intrinsic and acquired resistance. However, treatment with a CD47 monoclonal antibody in combina
Externí odkaz:
https://doaj.org/article/88f427a2882642b7b2f32986f378f0e2
Autor:
Shirley Greenwald, Ayelet Chajut, Alexandra Aronin, Amnon Peled, Matthew Weber, Ami Tamir, Iris Pecker, Rinat Tabakman, Lucy Ganthous, Liat Tamir, Roy Kahn, Jasmine Avichzer, Elina Zorde-Khvalevsky, Michal Michal Elhalel Dranitzki, Adam Foley-Comer, Mark Tykocinski
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/9d1d813fb3514e5b91af359675727c2a
Autor:
Matthew P. Weber, Elina Zorde-Khvalevsky, Amnon Peled, Adam Foley-Comer, Ami Tamir, Ayelet Chajut, Lucy Ganthous, Alexandra Aronin, Rinat Tabakman, Shirley Greenwald, Jasmine Avichzer, Roy Kahn, Mark L. Tykocinski, Iris Pecker, Liat Ben Gigi Tamir, Michal Michal Elhalel Dranitzki
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTIGIT, an inhibitory immune checkpoint, is a target of interest for immuno-oncology combination therapies. TIGIT is part of a complex molecular network containing four receptors (DNAM1, TIGIT, PVRIG and CD96) and two ligands (PVR and PVRL2)
Autor:
Ami Tamir, Adam Foley-Comer, Michal Dranitzki-Elhalel, Yaron Pereg, Shira Amsili, Amnon Peled, Alexandra Aronin, Shirley Greenwald, Ayelet Chajut, Liat Ben-gigi-Tamir, Susan Hilgendorf, Yehudith Sagiv, Iris Pecker, Yosi Gozlan, Edwin Bremer
Publikováno v:
Cancer Immunology Research. 7:A076-A076
Background: The (re)activation of anticancer innate and adaptive immunity is at the forefront of developments in cancer therapy. Here, we report on a new immunotherapeutic fusion protein, termed Dual Signaling Protein 107 (DSP107). DSP107 was designe
Autor:
Yu Min, Li Shu-yu, Qiu Xueshan, Gu Yu-mei, Iris Pecker, Zhang Siyang, Wang En-hua, Han Yu-chen
Publikováno v:
Chinese Journal of Cancer Research. 17:207-212
Objective: To explore the expression and significance of heparanase in non-small cell lung cancer (NSCLC) regarding prognosis and clinicopathological parameters. Methods: The expression of heparanase was assessed using immunohistochemistry staining a
Autor:
Neta Ilan, Liat Nadav, Oron Yacoby-Zeevi, Benjamin Geiger, Eli Zamir, Israel Vlodavsky, Iris Pecker, Amiram Eldor, Ben-Zion Katz
Publikováno v:
Journal of Cell Science. 115:2179-2187
Heparanase is a heparan-sulfate-degrading endoglycosidase that has important roles in various biological processes, including angiogenesis, wound healing and metastatsis. Human heparanase is synthesized as a 65 kDa latent precursor, which is proteoly
Autor:
Helena Aingorn, Eduardo Mitrani, Israel Michal, Iris Pecker, Orit Goldshmidt, Eyal Zcharia, Ruth Atzmon, Israel Vlodavsky, Zehava Guatta-Rangini
Publikováno v:
Journal of Biological Chemistry. 276:29178-29187
Cleavage of heparan sulfate (HS) proteoglycans affects the integrity and function of tissues and thereby fundamental phenomena, involving cell migration and response to changes in the extracellular microenvironment. The role of HS-degrading enzymes,
Autor:
Tova Chajek-Shaul, Yael Friedmann, Ayelet Aviv, Michael Elkin, Israel Vlodavsky, Eyal Zcharia, Iris Pecker, Tamar Peretz, Orit Pappo, Shula Metzger
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia. 6:311-322
Tumor spread involves degradation of various components of the extracellular matrix and blood vessel wall. Among these is heparan sulfate proteoglycan, which plays a key role in the self-assembly, insolubility and barrier properties of basement membr
Autor:
Menachem Bitan, Tuvia Peretz, Yael Friedmann, Iris Pecker, Rivka Ishai-Michaeli, Michael Elkin, Israel Michal, Ruth Atzmon, Israel Vlodavsky, Helena Aingorn, Orit Pappo, Larissa Spector
Publikováno v:
Nature Medicine. 5:793-802
Heparan sulfate proteoglycans interact with many extracellular matrix constituents, growth factors and enzymes. Degradation of heparan sulfate by endoglycosidic heparanase cleavage affects a variety of biological processes. We have purified a 50-kDa
Publikováno v:
Pure and Applied Chemistry. 69:2151-2158
During recent years genes for more than 20 different carotenogenic enzymes have been cloned from various organisms: bacteria, cyanobacteria, fungi, algae and plants. This accomplishment has provided new molecular tools to study the enzymes and yielde