Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Iris P L Wong"'
Autor:
Iris P L Wong, Frank Driessler, Ee Cheng Khor, Yan-Chuan Shi, Birgit Hörmer, Amy D Nguyen, Ronaldo F Enriquez, John A Eisman, Amanda Sainsbury, Herbert Herzog, Paul A Baldock
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40038 (2012)
BACKGROUND & AIMS: Gastrointestinal peptides are increasingly being linked to processes controlling the maintenance of bone mass. Peptide YY (PYY), a gut-derived satiety peptide of the neuropeptide Y family, is upregulated in some states that also di
Externí odkaz:
https://doaj.org/article/9b5a975859f44dad89830eefd9b9e082
Autor:
Yan-Chuan Shi, Shu Lin, Iris P L Wong, Paul A Baldock, Aygul Aljanova, Ronaldo F Enriquez, Lesley Castillo, Natalie F Mitchell, Ji-Ming Ye, Lei Zhang, Laurence Macia, Ernie Yulyaningsih, Amy D Nguyen, Sabrina J Riepler, Herbert Herzog, Amanda Sainsbury
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11361 (2010)
BACKGROUND: Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-mediated effects on energy homeostasis and bone physiology. Y2 receptors are located post-synaptically as well as acting as auto receptors on NPY-expressing neurons,
Externí odkaz:
https://doaj.org/article/5a19b312bbf446788da289e4c0421dff
Autor:
Paul A Baldock, Nicola J Lee, Frank Driessler, Shu Lin, Susan Allison, Bernhard Stehrer, En-Ju D Lin, Lei Zhang, Ronald F Enriquez, Iris P L Wong, Michelle M McDonald, Matthew During, Dominique D Pierroz, Katy Slack, Yan C Shi, Ernie Yulyaningsih, Aygul Aljanova, David G Little, Serge L Ferrari, Amanda Sainsbury, John A Eisman, Herbert Herzog
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8415 (2009)
Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status.
Externí odkaz:
https://doaj.org/article/1c4e10f85e774d4ab672cfe858d76d32
Autor:
Emmy W. Verschuren, Pekka Paivinen, Sushil Tripathi, Ashwini S. Nagaraj, Eva Domenech-Moreno, Tomi P. Mäkelä, Kari Vaahtomeri, Iris P. L. Wong, Sarang S. Talwelkar, Marc Foretz, Benoit Viollet, Yan Yan, Yajing Gao
Publikováno v:
Clinical Cancer Research
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment and maintenance of a cold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cf3262a0c4c81d50687c579b0bc47b
https://doi.org/10.1158/1078-0432.ccr-21-2049
https://doi.org/10.1158/1078-0432.ccr-21-2049
Autor:
Yajing, Gao, Yan, Yan, Sushil, Tripathi, Nalle, Pentinmikko, Ana, Amaral, Pekka, Päivinen, Eva, Domènech-Moreno, Simon, Andersson, Iris P L, Wong, Hans, Clevers, Pekka, Katajisto, Tomi P, Mäkelä
Publikováno v:
Gastroenterology. 158(5)
In addition to the Notch and Wnt signaling pathways, energy metabolism also regulates intestinal stem cell (ISC) function. Tumor suppressor and kinase STK11 (also called LKB1) regulates stem cells and cell metabolism. We investigated whether loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b44b88e835573c67660bf002279464bd
https://pubmed.ncbi.nlm.nih.gov/31930988
https://pubmed.ncbi.nlm.nih.gov/31930988
Autor:
Tomi P. Mäkelä, Kari Vaahtomeri, Yajing Gao, Sushil Tripathi, Iris P. L. Wong, Benoit Viollet, Eva Domenech-Moreno, Yan Yan, Nalle Pentinmikko, Timothy C. Wang, Gustavo Leone, Elina H. Niemelä, Saara Ollila, Kaisa Laajanen, Pekka Katajisto
Publikováno v:
Journal of Clinical Investigation
Journal of Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
Journal of Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
International audience; Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse models; however, the cell types and signaling pathways underlying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6274585620cb1bbf0318b556f33ec3f5
https://pubmed.ncbi.nlm.nih.gov/29202476
https://pubmed.ncbi.nlm.nih.gov/29202476
Autor:
Ronaldo F. Enriquez, Sonia Janmaat, Yan-Chuan Shi, Lesley Castillo, Ayse Zengin, Brigitte L. Kieffer, Ernie Yulyaningsih, Paul A. Baldock, Iris P. L. Wong, John A. Eisman, Frank Driessler, Herbert Herzog, Shu Lin, Christoph Schwarzer, Amanda Sainsbury
Publikováno v:
Neuropeptides. 46:383-394
Chronic opiate usage, whether prescribed or illicit, has been associated with changes in bone mass and is a recognized risk factor for the development of osteoporosis; however, the mechanism behind this effect is unknown. Here we show that lack of dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660e040169c4f4a7ca81506c0b94f747
https://doi.org/10.1016/j.npep.2012.08.010
https://doi.org/10.1016/j.npep.2012.08.010
Publikováno v:
Seminars in Cell & Developmental Biology. 19:452-458
The traditional view of skeletal homeostasis as a primarily endocrine activity has been expanded in recent years following the identification of direct neural pathways controlling bone homeostasis via central relays. Powerful control over both anabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006046952ceb6a398d6b3a42aff1ca4b
https://doi.org/10.1016/j.semcdb.2008.08.001
https://doi.org/10.1016/j.semcdb.2008.08.001
Publikováno v:
Current Osteoporosis Reports. 6:62-66
Leptin and its actions in bone came to prominence in 2000, with the publication of two landmark articles identifying a novel interaction between energy and bone homeostasis, as well as a novel hypothalamic circuit to the skeleton. However, they also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0c7e77ba573ec3d56e18eaa4eb849e
https://doi.org/10.1007/s11914-008-0011-y
https://doi.org/10.1007/s11914-008-0011-y
Autor:
Yan Yan, Tea Vallenius, Tomi P. Mäkelä, Iris P. L. Wong, Jorma J. Palvimo, Kari Vaahtomeri, Saara Ollila
Publikováno v:
Nature Communications
Article
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66609806e6560b215a785df5efc6527b
http://hdl.handle.net/10138/165272
http://hdl.handle.net/10138/165272
