Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Iris Oren"'
Autor:
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3592-3604.e5 (2019)
Summary: A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotype
Externí odkaz:
https://doaj.org/article/5c607706c23f4f7d92a682e925ca0372
Autor:
Pooja Jain, Jane Tulloch, Abigail G. Herrmann, Tara L. Spires-Jones, Anna J. Stevenson, Olga Netsyk, Oliver Hardt, Iris Oren, Eleanor K. Pickett
Publikováno v:
Tulloch, J, Netsyk, O, Pickett, E, Herrmann, A, Jain, P, Stevenson, A, Oren, I, Hardt, O & Spires-Jones, T 2020, ' Maintained memory and long-term potentiation in a mouse model of Alzheimer’s disease with both amyloid pathology and human tau ', European Journal of Neuroscience . https://doi.org/10.1111/ejn.14918
European Journal of Neuroscience
European Journal of Neuroscience
One of the key knowledge gaps in the field of Alzheimer's disease research is the lack of understanding of how amyloid beta and tau cooperate to cause neurodegeneration. We recently generated a mouse model (APP/PS1 + Tau) that develops amyloid plaque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a042a42f3702fbf4b48111c4dbfa2a
https://www.pure.ed.ac.uk/ws/files/156892620/Tulloch2020_ACCEPTED_FOR_PURE.pdf
https://www.pure.ed.ac.uk/ws/files/156892620/Tulloch2020_ACCEPTED_FOR_PURE.pdf
Autor:
Tara L. Spires-Jones, Jane Tulloch, Pooja Jain, Olga Netsyk, Anna J. Stevenson, Iris Oren, Oliver Hardt, Abigail G. Herrmann, Eleanor K. Pickett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7453ff77f8ae226fe5ab183b48c81e4a
https://doi.org/10.1111/ejn.14918/v2/response1
https://doi.org/10.1111/ejn.14918/v2/response1
Autor:
C. McKenzie, Jane Tulloch, Monique Hooley, Rosemary J. Jackson, Sadaf Sohrabi, Marie d'Orange, Elizabeth Allison, Kimberly Abt, Makis Tzioras, Anna J. Stevenson, Maria P. Fjeldstad, Sophie Dunnett, Will Calkin, Colin Smith, Giles E. Hardingham, Owen Dando, Caitlin Davies, Leo Murison, Eleanor K. Pickett, Tara L. Spires-Jones, Iris Oren, Christopher M. Henstridge, Jamie McQueen, Abigail G. Herrmann, Oliver Hardt, Jamie Rose, Pooja Jain
Publikováno v:
SSRN Electronic Journal.
SummaryOne of the key knowledge gaps blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) and tau cooperate in causing disease phenotypes. Within a mouse tau deficient ba
Publikováno v:
Zemankovics, R, Veres, J M, Oren, I & Hájos, N 2013, ' Feedforward Inhibition Underlies the Propagation of Cholinergically Induced Gamma Oscillations from Hippocampal CA3 to CA1 ', The Journal of Neuroscience, vol. 33, no. 30, pp. 12337-12351 . https://doi.org/10.1523/JNEUROSCI.3680-12.2013
Gamma frequency (30–80 Hz) oscillations are implicated in memory processing. Such rhythmic activity can be generated intrinsically in the CA3 region of the hippocampus from where it can propagate to the CA1 area. To uncover the synaptic mechanisms
Publikováno v:
Oren, I, Nissen, W, Kullmann, D M, Somogyi, P & Lamsa, K P 2009, ' Role of ionotropic glutamate receptors in long-term potentiation in rat hippocampal CA1 oriens-lacunosum moleculare interneurons ', Journal of Neuroscience, vol. 29, no. 4, pp. 939-950 . https://doi.org/10.1523/JNEUROSCI.3251-08.2009
Some interneurons of the hippocampus exhibit NMDA receptor-independent long-term potentiation (LTP) that is induced by presynaptic glutamate release when the postsynaptic membrane potential is hyperpolarized. This “anti-Hebbian” form of LTP is pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49602a6c9397229fb704a89718b324a
https://doi.org/10.1523/jneurosci.3251-08.2009
https://doi.org/10.1523/jneurosci.3251-08.2009
Publikováno v:
The Journal of Physiology. 588:785-797
Gamma frequency oscillations (30–100 Hz) are prominent in the hippocampal EEG signal during active network states. An intrahippocampal gamma generator has been identified in the CA3 region. To understand the mechanism of oscillation generation, bot
Publikováno v:
The Journal of Neuroscience. 26:9923-9934
Gamma-frequency oscillations are prominent during active network states in the hippocampus. An intrahippocampal gamma generator has been identified in the CA3 region. To better understand the synaptic mechanisms involved in gamma oscillogenesis, we r
Gamma oscillations in the dentate gyrus and hippocampal CA3 show variable coherence in vivo, but the mechanisms and relevance for information flow are unknown. We found that carbachol-induced oscillations in rat CA3 have biphasic phase-response curve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4307c3da4ab2a8a4309cdcc4921bc59
https://europepmc.org/articles/PMC3378654/
https://europepmc.org/articles/PMC3378654/
Autor:
Iris Oren, Ole Paulsen
The reports of Caton (1875) and Berger (1929) provided the earliest suggestions that the electroencephalogram (EEG) carries information about the brain's activity. However, while recordings of the EEG and the extracellular local field potential (LFP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59edca81da36151d229445ddc26791c2
https://europepmc.org/articles/PMC2911207/
https://europepmc.org/articles/PMC2911207/