Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Iris OZ"'
Autor:
Patrick J. Murphy, Gregory P. Black, Elliot L. Bennett, Claire Martin, Iris Oz-Gleenberg, Amnon Hizi, Andrew J. Thornhill, Terence D. Roberts, Patrick Browne, John P. Leyland, Mohammed Jaffar, Steven A. Vale
Publikováno v:
Tetrahedron. 69:3061-3066
Several analogues of the left hand portion of batzelladine F were prepared using a rapid and convergent methodology and evaluated for activity against HIV-1 reverse transcriptase (RT) and several cancer cell lines.
Publikováno v:
FEBS Journal. 279:1894-1903
We have recently shown that reverse transcriptases (RTs) perform template switches when there is a very short (two-nucleotide) complementarity between the 3′ ends of the primer (donor) strand and the DNA or RNA template acceptor strands [Oz-Gleenbe
Publikováno v:
FEBS Journal. 279:142-153
Reverse transcriptases (RTs) possess a non-templated addition (NTA) activity while synthesizing DNA with blunt-ended DNA primer/templates. Interestingly, the RT of the long terminal repeat retrotransposon Tf1 has an NTA activity that is substantially
Publikováno v:
Nucleic Acids Research
We present evidence that the reverse transcriptase (RT) of human immunodeficiency virus type-1 stabilizes in vitro very short (2-nt) duplexes of 3'-overhangs of the primer strand that are annealed to complementary dinucleotides tails of DNA or RNA te
Publikováno v:
Biochemical Journal. 412:163-170
The RT (reverse transcriptase) of HIV-1 interacts with HIV-1 IN (integrase) and inhibits its enzymatic activities. However, the molecular mechanisms underling these interactions are not well understood. In order to study these mechanisms, we have ana
Publikováno v:
Journal of Molecular Biology. 369:1230-1243
Shortly after infection by human immunodeficiency virus (HIV), two complexes are formed in a stepwise manner in the cytoplasm of infected cells: the reverse transcription complex that later becomes the preintegration complex. Both complexes include,
Publikováno v:
Journal of Biological Chemistry. 280:21987-21996
Recent studies have shown that the integrase (IN) of HIV-1 is inhibited in vitro by HIV-1 reverse transcriptase (RT). We further investigated the specific protein sequences of RT that were involved in this inhibition by screening a complete library o
Publikováno v:
Biochemical Journal. 361:557-566
We present evidence that the integrases (INs) of HIV types 1 and 2 are inhibited in vitro by the reverse transcriptases (RTs) of HIV-1, HIV-2 and murine leukaemia virus. Both 3′-end processing and 3′-end joining (strand transfer) activities of IN
Publikováno v:
The FEBS journal. 279(10)
We have recently shown that reverse transcriptases (RTs) perform template switches when there is a very short (two-nucleotide) complementarity between the 3' ends of the primer (donor) strand and the DNA or RNA template acceptor strands [Oz-Gleenberg
Publikováno v:
The FEBS journal. 279(1)
Reverse transcriptases (RTs) possess a non-templated addition (NTA) activity while synthesizing DNA with blunt-ended DNA primer/templates. Interestingly, the RT of the long terminal repeat retrotransposon Tf1 has an NTA activity that is substantially