Pharmacological inhibition of CDK4/6 impairs diffuse pleural mesothelioma 3D spheroid growth and reduces viability of cisplatin-resistant cells

Autor: Aurora Costa, Iris Maria Forte, Francesca Pentimalli, Carmelina Antonella Iannuzzi, Luigi Alfano, Francesca Capone, Rosa Camerlingo, Alessandra Calabrese, Claudia von Arx, Reyes Benot Dominguez, Massimiliano Quintiliani, Michelino De Laurentiis, Andrea Morrione, Antonio Giordano

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionDiffuse pleural mesothelioma (DPM) of the pleura is a highly aggressive and treatment-resistant cancer linked to asbestos exposure. Despite multimodal treatment, the prognosis for DPM patients remains very poor, with an average survival o

Externí odkaz: https://doaj.org/article/b853fb46d9b3462d81cf3795b07f7ee6

The Oncolytic Caprine Herpesvirus 1 (CpHV-1) Induces Apoptosis and Synergizes with Cisplatin in Mesothelioma Cell Lines: A New Potential Virotherapy Approach

Autor: Iris Maria Forte, Paola Indovina, Serena Montagnaro, Aurora Costa, Carmelina Antonella Iannuzzi, Francesca Capone, Rosa Camerlingo, Anna Maria Malfitano, Francesca Pentimalli, Gianmarco Ferrara, Massimiliamo Quintiliani, Giuseppe Portella, Antonio Giordano, Roberto Ciarcia

Publikováno v: Viruses, Vol 13, Iss 12, p 2458 (2021)

Malignant mesothelioma (MM) is an aggressive asbestos-related cancer, against which no curative modalities exist. Oncolytic virotherapy is a promising therapeutic approach, for which MM is an ideal candidate; indeed, the pleural location provides dir

Externí odkaz: https://doaj.org/article/8f3394d13d974c7ca2da05c47c64a3d5

HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis

Autor: Pierpaolo Correale, Rita Emilena Saladino, Diana Giannarelli, Andrea Sergi, Maria Antonietta Mazzei, Giovanna Bianco, Rocco Giannicola, Eleonora Iuliano, Iris Maria Forte, Natale Daniele Calandruccio, Antonia Consuelo Falzea, Alessandra Strangio, Valerio Nardone, Pierpaolo Pastina, Paolo Tini, Amalia Luce, Michele Caraglia, Daniele Caracciolo, Luciano Mutti, Pierfrancesco Tassone, Luigi Pirtoli, Antonio Giordano, Pierosandro Tagliaferri

Publikováno v: Cells, Vol 9, Iss 9, p 1964 (2020)

Tumor-infiltrating T cell rescue by programmed cell death receptor-1 (PD-1)/PD-1 ligand-1 (PD-L1) immune checkpoint blockade is a recommended treatment for malignant diseases, including metastatic non-small-cell lung cancer (mNSCLC), malignant melano

Externí odkaz: https://doaj.org/article/d23b3e92387b474e869261944ae728ba

P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma

Autor: Luciano Mutti, Francesca Pentimalli, Marisa De Feo, Antonio Giordano, Cristiana Bellan, Enrico M. Bucci, Luca Luzzi, Paola Indovina, Simona De Summa, Eliseo Mattioli, Domenico Di Marzo, Carmelina Antonella Iannuzzi, Iris Maria Forte, Caterina Costa

Publikováno v: Cell Death and Disease, Vol 11, Iss 9, Pp 1-15 (2020)
Cell Death & Disease

Malignant pleural mesothelioma (MPM) is an aggressive cancer, related to asbestos exposure, which has a dismal prognosis. MPM diagnosis is late and often challenging, suggesting the need to identify more reliable molecular biomarkers. Here, we set ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41aabc1ba91c4ca976bd86a746c5e8d0
http://link.springer.com/article/10.1038/s41419-020-02940-w

The Oncolytic Virus dl922-947 Triggers Immunogenic Cell Death in Mesothelioma and Reduces Xenograft Growth

Autor: Gerardo Botti, Pietro Formisano, Carmela Passaro, Francesca Pentimalli, Paola Indovina, Raffaella Iannone, Antonio Giordano, Carmelina Antonella Iannuzzi, Anna Maria Malfitano, Iris Maria Forte, Giuseppe Portella, Sarah Di Somma, Vincenzo Gigantino

Publikováno v: Frontiers in oncology (2019).
info:cnr-pdr/source/autori:Sarah Di Somma 1, Carmelina Antonella Iannuzzi 2, Carmela Passaro 1, Iris Maria Forte 2, Raffaella Iannone 1, Vincenzo Gigantino 3, Paola Indovina 4, Gerardo Botti 5, Antonio Giordano 4 6, Pietro Formisano 1, Giuseppe Portella 1, Anna Maria Malfitano 1, Francesca Pentimalli 2/titolo:The Oncolytic Virus dl 922-947 Triggers Immunogenic Cell Death in Mesothelioma and Reduces Xenograft Growth/doi:/rivista:Frontiers in oncology/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume
Frontiers in Oncology
Frontiers in Oncology, Vol 9 (2019)

Background: Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure that urgently requires effective therapeutic strategies. Current treatments are unable to increase significantly patient survival, which is oft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869b0f72ca60c0fdfb63a594666d3203
https://doi.org/10.3389/fonc.2019.00564