Mild dyserythropoiesis and β-like globin gene expression imbalance due to the loss of histone chaperone ASF1B

Autor: Petros Papadopoulos, Athanassia Kafasi, Iris M. De Cuyper, Vilma Barroca, Daniel Lewandowski, Zahra Kadri, Martijn Veldthuis, Jeffrey Berghuis, Nynke Gillemans, Celina María Benavente Cuesta, Frank G. Grosveld, Rob van Zwieten, Sjaak Philipsen, Muriel Vernet, Laura Gutiérrez, George P. Patrinos

Publikováno v: Human Genomics, Vol 14, Iss 1, Pp 1-12 (2020)

Abstract The expression of the human β-like globin genes follows a well-orchestrated developmental pattern, undergoing two essential switches, the first one during the first weeks of gestation (ε to γ), and the second one during the perinatal peri

Externí odkaz: https://doaj.org/article/ebde74cd3e4042dc96bb58a33041796f

The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis

Autor: Wiebke Herzog, Lanette Kempers, Dirk de Korte, Iris M. De Cuyper, Ivo van der Bijl, Aldo Jongejan, Yuki Wakayama, Antonius L. van Boxtel, Marije Kat, Marvin Hubert, Anne-Marieke D. van Stalborch, Charita Furumaya, Coert Margadant, Dirk Geerts, Jaap D. van Buul

Publikováno v: Angiogenesis
Angiogenesis, 24(3), 695-714. Springer Netherlands
Kempers, L, Wakayama, Y, van der Bijl, I, Furumaya, C, de Cuyper, I M, Jongejan, A, Kat, M, van Stalborch, A-M D, van Boxtel, A L, Hubert, M, Geerts, D, van Buul, J D, de Korte, D, Herzog, W & Margadant, C 2021, ' The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis ', Angiogenesis, vol. 24, no. 3, pp. 695-714 . https://doi.org/10.1007/s10456-021-09788-4, https://doi.org/10.1007/s10456-021-09788-4

Sprouting angiogenesis is key to many pathophysiological conditions, and is strongly regulated by vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we report that the early endosomal GTPase Rab5C and its activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeac18f57f69b93f205e720a01defc96
http://europepmc.org/articles/PMC8292304

The effect of red blood cell transfusion on platelet function in critically ill patients

Autor: Rienk Nieuwland, Marleen Straat, Maike E. van Hezel, Michael W.T. Tanck, Nicole P. Juffermans, Boukje M. Beuger, Robin van Bruggen, Margit Boshuizen, Iris M. De Cuyper, Jaap Jan Zwaginga, Lisa van Manen, Dirk de Korte

Publikováno v: Thrombosis research, 184, 115-121. Elsevier Limited
Thrombosis Research, 184, 115-121

Introduction Red blood cell (RBC) transfusion is associated with an increased risk of pro-thrombotic events, but the underlying mechanism is poorly understood. We hypothesized that RBC transfusion modulates platelet activity in critically ill patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfbdc7750ac1c65d2be4e319491091e
https://doi.org/10.1016/j.thromres.2019.10.028

Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation

Autor: Femke P. M. Hoevenaars, Geerten P van Nieuw Amerongen, Jan van Bezu, Anne-Marieke D. van Stalborch, Iris M. De Cuyper, Coert Margadant, Etto C. Eringa, Jurjan Aman, Erik T. Valent, Kalim Nawaz, Victor W.M. van Hinsbergh, Peter L. Hordijk, Joana Amado-Azevedo

Publikováno v: Angiogenesis, 24(3), 677-693. Springer Netherlands
Angiogenesis
Amado-Azevedo, J, van Stalborch, A-M D, Valent, E T, Nawaz, K, van Bezu, J, Eringa, E C, Hoevenaars, F P M, de Cuyper, I M, Hordijk, P L, van Hinsbergh, V W M, van Nieuw Amerongen, G P, Aman, J & Margadant, C 2021, ' Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation ', Angiogenesis, vol. 24, no. 3, pp. 677-693 . https://doi.org/10.1007/s10456-021-09781-x

Endothelial barrier disruption and vascular leak importantly contribute to organ dysfunction and mortality during inflammatory conditions like sepsis and acute respiratory distress syndrome. We identified the kinase Arg/Abl2 as a mediator of endothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8958d86f669b5defa5bdce1ae8fc5fe
https://pure.amc.nl/en/publications/depletion-of-argabl2-improves-endothelial-cell-adhesion-and-prevents-vascular-leak-during-inflammation(8db11006-b7f4-4439-bcee-753401ba6b23).html

Comparison of the PU.1 transcriptional regulome and interactome in human and mouse inflammatory dendritic cells

Autor: Vishal Salunkhe, Sjaak Philipsen, Rutger W W Brouwer, Timo K. van den Berg, Nynke Gillemans, Jeroen Demmers, Lianne van de Laar, Erikjan Rijkers, Wilfred F. J. van IJcken, Noemí Caballero-Sánchez, Iris M. De Cuyper, Pieter De Bleser, Maaike R. Scheenstra, Laura Gutierrez, Andrea Acebes-Huerta, Patricia Martínez-Botía, Benjamin Nota, Andrea M. Woltman, Taco W. Kuijpers

Publikováno v: RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Journal of leukocyte biology, 110(4), 735-751. FASEB
Journal of Leukocyte Biology, 1-17. John Wiley & Sons Inc.
STARTPAGE=1;ENDPAGE=17;ISSN=0741-5400;TITLE=Journal of Leukocyte Biology

Dendritic cells (DCs) are key immune modulators and are able to mount immune responses or tolerance. DC differentiation and activation imply a plethora of molecular and cellular responses, including transcriptional changes. PU.1 is a highly expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948526b0e9c69ecf828402662f0b66b5
http://hdl.handle.net/10651/57182