Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Iris K. Minichmayr"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 2, Pp 222-233 (2024)
Abstract Appropriate antibiotic dosing to ensure early and sufficient target attainment is crucial for improving clinical outcome in critically ill patients. Parametric survival analysis is a preferred modeling method to quantify time‐varying antib
Externí odkaz:
https://doaj.org/article/0e08e7f1feea4fbb8164c1b66de91999
Publikováno v:
Antibiotics, Vol 11, Iss 8, p 1036 (2022)
Pharmacokinetic-pharmacodynamic (PKPD) models have met increasing interest as tools to identify potential efficacious antibiotic dosing regimens in vitro and in vivo. We sought to investigate the impact of diversely shaped clinical pharmacokinetic pr
Externí odkaz:
https://doaj.org/article/eef5c854ae064f5e86eb86c08b46286f
Autor:
Lisa Ehmann, Michael Zoller, Iris K. Minichmayr, Christina Scharf, Barbara Maier, Maximilian V. Schmitt, Niklas Hartung, Wilhelm Huisinga, Michael Vogeser, Lorenz Frey, Johannes Zander, Charlotte Kloft
Publikováno v:
Critical Care, Vol 21, Iss 1, Pp 1-14 (2017)
Abstract Background Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has been associated with clinical success in critically ill patients. The ob
Externí odkaz:
https://doaj.org/article/c9b0a86d58c348a3b5406cd76084c7c9
Publikováno v:
Pharmaceutical Research
Pharmaceutical research
Pharmaceutical research
Purpose Pharmacometric models provide useful tools to aid the rational design of clinical trials. This study evaluates study design-, drug-, and patient-related features as well as analysis methods for their influence on the power to demonstrate a be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4fe91bf942afa8a99ed72524e69930
https://doi.org/10.1007/s11095-021-03024-w
https://doi.org/10.1007/s11095-021-03024-w
Autor:
Sebastian G. Wicha, Jan-Willem C. Alffenaar, Anne-Grete Märtson, Birgit C. P. Koch, Lena E. Friberg, Elisabet I. Nielsen, Iris K. Minichmayr
Publikováno v:
Clinical Pharmacology & Therapeutics. 109:928-941
Therapeutic drug monitoring (TDM) and model-informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in individual patients with infections. In particular, critically ill patients display altered, high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c708b71dda6e0ec9935b269b2a1732c
https://doi.org/10.1002/cpt.2202
https://doi.org/10.1002/cpt.2202
Publikováno v:
International journal of antimicrobial agents. 60(3)
Pharmacokinetic/pharmacodynamic (PKPD) models have emerged as valuable tools for the characterization and translation of antibiotic effects, and consequently for drug development and therapy. In contrast to traditional PKPD concepts for antibiotics s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ea9186f00b92a2fff4c5636b843f8d
https://pubmed.ncbi.nlm.nih.gov/35691605
https://pubmed.ncbi.nlm.nih.gov/35691605
Autor:
Wilhelm Huisinga, Lisa Ehmann, Christina Scharf, Johannes Zander, Iris K. Minichmayr, Charlotte Kloft, Michael Zoller
Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill patients. Population pharma-cokinetic (PK) modelling was perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3098864f4aafdb57a5cd95111e48ee2b
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/48282
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/48282
Publikováno v:
Clinical Pharmacokinetics. 56:617-633
We aimed to assess linezolid pharmacokinetics in the plasma and interstitial space fluid (ISF) of patients with sepsis, diabetic foot infections or cystic fibrosis and healthy volunteers. The impacts of joint characteristics and disease on plasma and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dab29e41ed429e9ec760aaf2036dbd2
https://doi.org/10.1007/s40262-016-0463-7
https://doi.org/10.1007/s40262-016-0463-7
Autor:
Anka C Roehr, Jason A. Roberts, Charlotte Kloft, Iris K. Minichmayr, A. Brinkmann, Otto R Frey
Background: Optimal antibiotic exposure is a vital but challenging prerequisite for achieving clinical success in ICU patients. Objectives: To develop and externally validate a population pharmacokinetic model for continuous-infusion meropenem in cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7db39f04b4bed4049b4a37aa6455d0
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/52921
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/52921
Autor:
Iris K. Minichmayr, Markus Zeitlinger
Publikováno v:
Clinical Pharmacokinetics. 58:981-982
Comment on "Target-Controlled Continuous Infusion for Antibiotic Dosing : Proof-of-Principle in an In-silico Vancomycin Trial in Intensive Care Unit Patients"
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d2125718911b8d6f5779f202dceaf6
https://doi.org/10.1007/s40262-019-00768-y
https://doi.org/10.1007/s40262-019-00768-y