Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Iris Grossman"'
Autor:
Shahar Sofer, Zlata Vershinin, Leen Mashni, Ran Zalk, Anat Shahar, Jerry Eichler, Iris Grossman-Haham
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The swimming device of archaea—the archaellum—presents asparagine (N)-linked glycans. While N-glycosylation serves numerous roles in archaea, including enabling their survival in extreme environments, how this post-translational modifica
Externí odkaz:
https://doaj.org/article/e21d45cd85f745c8a891faf697ba47e0
Autor:
Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn Akerberg, Bryan Matthews, Jenna Williams, Gabriel Golczer, Jiaqi Huang, Ali Al Abdullatif, Dann Huh, Linda C. Burkly, Sandra J. Engle, Iris Grossman, Alfica Sehgal, Alla A. Sigova, Robert T. Fremeau, Yuting Liu, David Bumcrot
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Microglia are the resident immune cells in the brain that play a key role in driving neuroinflammation, a hallmark of neurodegenerative disorders. Inducible microglia-like cells have been developed as an in vitro platform for molecular and t
Externí odkaz:
https://doaj.org/article/4c4615fe09d94a8f8fde0749950ac0b4
Autor:
Ohad Yogev, Omer Weissbrod, Giorgia Battistoni, Dario Bressan, Adi Naamati, Ilaria Falciatori, Ahmet Can Berkyurek, Roni Rasnic, Rhys Izuagbe, Myra Hosmillo, Shaul Ilan, Iris Grossman, Lauren McCormick, Christopher Cole Honeycutt, Timothy Johnston, Matthew Gagne, Daniel C Douek, Ian Goodfellow, Gregory James Hannon, Yaniv Erlich
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A genome-wide screen of 16,471 RNAi triggers targeting SARS-CoV-2 genome by Sens.AI. identifies hyper-potent RNAi candidates against SARS-CoV-2 that are further validated in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/ff02faec80454a3f8bad5508748dbbd4
Autor:
Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn Akerberg, Bryan Matthews, Jenna Williams, Gabriel Golczer, Jiaqi Huang, Ali Al Abdullatif, Dann Huh, Linda C. Burkly, Sandra J. Engle, Iris Grossman, Alfica Sehgal, Alla A. Sigova, Robert T. Fremeau, Yuting Liu, David Bumcrot
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/bc57d863a5f34f39b8a0f32bb4481c75
Autor:
Shani Cohen, Zeev Waks, Jordan J. Elm, Mark Forrest Gordon, Igor D. Grachev, Leehee Navon-Perry, Shai Fine, Iris Grossman, Spyros Papapetropoulos, Juha-Matti Savola
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background A growing number of clinical trials use various sensors and smartphone applications to collect data outside of the clinic or hospital, raising the question to what extent patients comply with the unique requirements of remote stud
Externí odkaz:
https://doaj.org/article/134b3a97a1744880bb450ac95d1ff202
Autor:
Daphna Laifenfeld, Chen Yanover, Michal Ozery-Flato, Oded Shaham, Michal Rosen-Zvi, Nirit Lev, Yaara Goldschmidt, Iris Grossman
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Real-world healthcare data hold the potential to identify therapeutic solutions for progressive diseases by efficiently pinpointing safe and efficacious repurposing drug candidates. This approach circumvents key early clinical development challenges,
Externí odkaz:
https://doaj.org/article/dc156503a87b429e88dde037a60bedd4
Autor:
Rebecca Kusko, Jennifer Dreymann, Jermaine Ross, Yoonjeong Cha, Renan Escalante-Chong, Marta Garcia-Miralles, Liang Juin Tan, Michael E. Burczynski, Ben Zeskind, Daphna Laifenfeld, Mahmoud Pouladi, Michal Geva, Iris Grossman, Michael R. Hayden
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-15 (2018)
Abstract Background Huntington Disease (HD) is an incurable autosomal dominant neurodegenerative disorder driven by an expansion repeat giving rise to the mutant huntingtin protein (mHtt), which is known to disrupt a multitude of transcriptional path
Externí odkaz:
https://doaj.org/article/9a4560e35e2b4547af97a466e9097c5b
Publikováno v:
BMC Medical Ethics, Vol 18, Iss 1, Pp 1-7 (2017)
Abstract Background As part of the preparations to establish a population-based biobank in a large Israeli health organization, we aimed to investigate through focus groups the knowledge, perceptions and attitudes of insured Israelis, toward biobanki
Externí odkaz:
https://doaj.org/article/0759639975f94ea6b03d17b38c6b2f52
Autor:
Colin J. Ross, Fadi Towfic, Jyoti Shankar, Daphna Laifenfeld, Mathis Thoma, Matthew Davis, Brian Weiner, Rebecca Kusko, Ben Zeskind, Volker Knappertz, Iris Grossman, Michael R. Hayden
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-15 (2017)
Abstract Background Copaxone is an efficacious and safe therapy that has demonstrated clinical benefit for over two decades in patients with relapsing forms of multiple sclerosis (MS). On an individual level, patients show variability in their respon
Externí odkaz:
https://doaj.org/article/c1be08a547904e9a8226e7d2e3152de0
Autor:
Daniel Ryskamp, Jun Wu, Michal Geva, Rebecca Kusko, Iris Grossman, Michael Hayden, Ilya Bezprozvanny
Publikováno v:
Neurobiology of Disease, Vol 97, Iss , Pp 46-59 (2017)
The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium spiny neurons (MSNs). HD is a devastating autosomal dominant disease with no di
Externí odkaz:
https://doaj.org/article/9663a4e2c25e4386a5bcd97f7b718930