Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Iris Fung"'
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sen
Externí odkaz:
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Autor:
Helen Yue-lai Chan, Yee-man Yau, Si-fan. Li, Ka-shi Kwong, Yuen-yu Chong, Iris Fung-kam Lee, Doris Sau-fung Yu
Publikováno v:
BMC Geriatrics, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background The Montessori Method underpinned by the principle of person-centered care has been widely adopted to design activities for people with dementia. However, the methodological quality of the existing evidence is fair. The objectives
Externí odkaz:
https://doaj.org/article/73e8633ca9354678b7224157b2de1e4c
Autor:
Chan, Helen Yue-Lai, Ng, Jeffrey Sheung-Ching, Chan, Kin-Sang, Ko, Po-Shan, Leung, Doris Yin-Ping, Chan, Carmen Wing-Han, Chan, Lai-Ngor, Lee, Iris Fung-Kam, Lee, Diana Tze-Fan
Publikováno v:
In International Journal of Nursing Studies November 2018 87:26-33
Autor:
Daniel P. Bondeson, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Carly Langan, Gabriel Mesa, Alfredo Gonzalez, Lauren E. Surface, Kentaro Ito, Mariya Kazachkova, William N. Colgan, Allison Warren, Joshua M. Dempster, John M. Krill-Burger, Maria Ericsson, Andrew A. Tang, Iris Fung, Emily S. Chambers, Mai Abdusamad, Nancy Dumont, John G. Doench, Federica Piccioni, David E. Root, Jesse Boehm, William C. Hahn, Michael Mannstadt, James M. McFarland, Francisca Vazquez, Todd R. Golub
Publikováno v:
Nature Cancer. 3:681-695
Despite advances in precision medicine, the clinical prospects for patients with ovarian and uterine cancers have not substantially improved. Here, we analyzed genome-scale CRISPR-Cas9 loss-of-function screens across 851 human cancer cell lines and f
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Natasha Rekhtman, Athea Vichas, Robert K. Bradley, Jacqueline Watson, John K. Lee, Austin M. Gabel, Marina K. Baine, Amanda K. Riley, Shriya Kamlapurkar, Federica Piccioni, James D. Thomas, Iris Fung, Naomi T. Nkinsi, Emily M. Hatch, Jennifer Chen, Marc Ladanyi, Matthew G. Rees, Fujiko Duke, April Lo, Phoebe C. R. Parrish, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer
Autor:
Francisca Vazquez, Iris Fung, Aviad Tsherniak, Thomas P. Howard, Brenton R. Paolella, Adam D. Durbin, Pratiti Bandopadhayay, Allison Warren, Charles W. M. Roberts, Andrew Tang, Andrew L. Hong, Clare F. Malone, James M. McFarland, Joshua M. Dempster, William C. Hahn, John M. Krill-Burger, Phoebe Moh, Caroline Wechsler, Lillian M. Guenther, Jesse S. Boehm, Philip Montgomery, Guillaume Kugener, Nishant Jha, Neekesh V. Dharia, Todd R. Golub, Kimberly Stegmaier
Publikováno v:
Nature genetics
Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional genomic approaches will yield new targets in pediatric cancers, known for remarkably few mutat
Autor:
Daniel Bondeson, Brenton Paolella, Adhana Asfaw, Michael Rothberg, Thomas Skipper, Gabriel Mesa, Alfredo Gonzalez, Lauren E. Surface, Kentaro Ito, Mariya Kazachkova, William N. Colgan, Allie Warren, Joshua Dempster, J Michael Krill-Burger, Maria Ericsson, Andrew Tang, Iris Fung, Emily S. Chambers, Mai Abdusamad, Nancy Dumont, John Doench, Federica Piccioni, David Root, Jesse Boehm, William C. Hahn, Michael Mannstadt, James McFarland, Francisca Vazquez, Todd Golub
Publikováno v:
Cancer Research. 82:1028-1028
Precision medicine promises to improve the treatment of cancer patients, but a lack of therapeutic targets and associated predictive biomarkers limit this reality. To identify novel strategies, we integrate genome-scale CRISPR viability screens acros
Autor:
Filip Mundt, Jacqueline Watson, Steven A. Carr, Sitapriya Moorthi, April Lo, Iris Fung, Shriya Kamlapurkar, Kristin D. Holmes, Alice H. Berger, Shaunt Fereshetian, Philipp Mertins
Publikováno v:
Sci Signal
Aberrant activation of the RAS family of guanosine triphosphatases (GTPases) is prevalent in lung adenocarcinoma, with somatic mutation of KRAS occurring in ~30% of tumors. We previously identified somatic mutations and amplifications of the gene enc
Autor:
Steven A. Carr, Jacqueline Watson, Iris Fung, Sitapriya Moorthi, K. Holmes, April Lo, Philipp Mertins, Filip Mundt, Shaunt Fereshetian, Alice H. Berger
Aberrant activation of RAS oncogenes is prevalent in lung adenocarcinoma, with somatic mutation ofKRASoccurring in ∼30% of tumors. Recently, we identified somatic mutation of the RAS-family GTPaseRIT1in lung adenocarcinoma, but relatively little is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24ed527f2a95ad624fc63d3db9d0dd6
https://doi.org/10.1101/2020.04.10.030460
https://doi.org/10.1101/2020.04.10.030460
Publikováno v:
International Journal of Nursing Practice. 26
Aims To explore the feasibility and effects of the programme based on information-motivation-behavioural skills (IMB) model (IMB programme) on adherence to inhalation therapy and other health outcomes in chronic obstructive pulmonary disease (COPD) p