Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium

Autor: B.J. Clark, C. Dela Cruz, Jonathan L. Koff, Y. Sun, Iris F. Ueki, Arielle M. Mulenos, Jay A. Nadel, Awo Osafo-Addo, Wei Liu, April Kalinowski, Benjamin T. Galen, J Joerns

Publikováno v: Mucosal immunology, vol 11, iss 3
Mucosal immunology

Respiratory syncytial virus (RSV) persists as a significant human pathogen that continues to contribute to morbidity and mortality. In children, RSV is the leading cause of lower respiratory tract infections, and in adults RSV causes pneumonia and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce51e5b33d3c828c72410e499621eee6
https://escholarship.org/uc/item/15p4s98h

Tumor necrosis factor α-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells

Autor: Jay A. Nadel, Iris F. Ueki, Matt X. G. Shao

Publikováno v: Proceedings of the National Academy of Sciences. 100:11618-11623

Ectodomain shedding of epidermal growth factor receptor (EGFR) ligands [e.g., transforming growth factor type α (TGF-α)] and EGFR phosphorylation are implicated in mucin production in airway epithelial cells. Tumor necrosis factor α-converting enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeaa7193c29cc2536d470737fbf287a
https://doi.org/10.1073/pnas.1534804100

IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway

Autor: Iris F. Ueki, Suil Kim, Jay A. Nadel, Dominic Cheng Wei Tam, Pierre-Régis Burgel, Trang Dao-Pick, Jae Jeong Shim

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L67-L75

Previous work showed that the Th2 cytokine interleukin (IL)-13 induces goblet cell metaplasia via an indirect mechanism involving the expression and subsequent activation of epidermal growth factor receptor (EGFR). Because Clara cell secretory protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2aff48a4fed48d934bcec20ae8b0e9f
https://doi.org/10.1152/ajplung.00404.2001

EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production

Autor: Gundula Min-Oo, Benjamin T. Galen, Eric Ballon-Landa, Iris F. Ueki, Jay A. Nadel, Lewis L. Lanier, David S. Knoff, Jonathan L. Koff, April Kalinowski

Publikováno v: American journal of physiology. Lung cellular and molecular physiology, vol 307, iss 2
Kalinowski, A; Ueki, I; Min-Oo, G; Ballon-Landa, E; Knoff, D; Galen, B; et al.(2014). EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. American Journal of Physiology-Lung Cellular and Molecular Physiology, 307(2), L186-L196. doi: 10.1152/ajplung.00368.2013. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9dd2t81m

Airway epithelial cells are the primary cell type involved in respiratory viral infection. Upon infection, airway epithelium plays a critical role in host defense against viral infection by contributing to innate and adaptive immune responses. Influe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8330984a8b8e9dd1e7ec704a83c955e3
https://escholarship.org/uc/item/9dd2t81m

Oxidative Stress Causes Mucin Synthesis Via Transactivation of Epidermal Growth Factor Receptor: Role of Neutrophils

Autor: Kiyoshi Takeyama, Jay A. Nadel, Karim Dabbagh, Jae Jeong Shim, Iris F. Ueki, Trang Dao-Pick

Publikováno v: The Journal of Immunology. 164:1546-1552

Oxidative stress has been implicated in the pathogenesis of inflammatory diseases of airways. Here we show that oxidative stress causes ligand-independent activation of epidermal growth factor receptors (EGFR) and subsequent activation of mitogen-act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ba7537d7f87740f00f65e16c124afa
https://doi.org/10.4049/jimmunol.164.3.1546