A proof-of-concept study with the tyrosine kinase inhibitor nilotinib in spondyloarthritis

Autor: Jacqueline E. Paramarta, Maureen C. Turina, Troy Noordenbos, Tanja F. Heijda, Iris C. Blijdorp, Nataliya Yeremenko, Dominique Baeten

Publikováno v: Journal of Translational Medicine, Vol 14, Iss 1, Pp 1-11 (2016)

Abstract Background To evaluate the immunomodulating and clinical effects of nilotinib, a tyrosine kinase inhibitor, in a proof-of-concept study in spondyloarthritis (SpA) assessing the mast cell as potential novel therapeutic target in this disease.

Externí odkaz: https://doaj.org/article/722a83161dc94d20834e95355bb29e41

BOB.1 controls memory B-cell fate in the germinal center reaction

Autor: Dominique Baeten, Lisa G. M. van Baarsen, Sophie Brouard, Maartje J. Levels, Tom O'Toole, Nataliya Yeremenko, Arjen Q. Bakker, Mikhail Krasavin, Cynthia M. Fehres, JF Semmelink, Iris C Blijdorp, Alexey Tomilin, Marieke E. Doorenspleet, Kristine Germar, Nathalie O. P. van Uden, Hergen Spits

Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, Elsevier, 2019, Epub ahead of print. ⟨10.1016/j.jaut.2019.04.011⟩
Journal of autoimmunity, 101, 131-144. Academic Press Inc.
Journal of Autoimmunity, 2019, Epub ahead of print. ⟨10.1016/j.jaut.2019.04.011⟩
Journal of Autoimmunity, 101, 131-144. Academic Press Inc.
Levels, M J, Fehres, C M, van Baarsen, L G M, van Uden, N O P, Germar, K, O'Toole, T G, Blijdorp, I C J, Semmelink, J F, Doorenspleet, M E, Bakker, A Q, Krasavin, M, Tomilin, A, Brouard, S, Spits, H, Baeten, D L P & Yeremenko, N G 2019, ' BOB.1 controls memory B-cell fate in the germinal center reaction ', Journal of Autoimmunity, vol. 101, pp. 131-144 . https://doi.org/10.1016/j.jaut.2019.04.011

International audience; During T cell-dependent (TD) germinal center (GC) responses, naïve B cells are instructed to differentiate towards GC B cells (GCBC), high-affinity long-lived plasma cells (LLPC) or memory B cells (Bmem). Alterations in the B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e232d10099951e3019af3160a7360f
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067009896&origin=inward

Interleukin 17A and IL-17F Expression and Functional Responses in Rheumatoid Arthritis and Peripheral Spondyloarthritis

Autor: Leonieke J J van Mens, Talia E. Latuhihin, Rowann Bowcutt, Sijia Chen, Marleen G H van de Sande, Stevan Shaw, Dominique Baeten, Nataliya Yeremenko, Iris C Blijdorp

Publikováno v: Journal of rheumatology, 47(11), 1606-1613. Journal of Rheumatology

Objective.Targeting the interleukin 17 (IL-17) axis is efficacious in psoriasis and spondyloarthritis (SpA), but not in rheumatoid arthritis (RA). We investigated potential differences in tissue expression and function of IL-17A and IL-17F in these c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ab172cfcfe5f2207cd185c9ab500b4
https://pubmed.ncbi.nlm.nih.gov/31941804

Brief Report: Interleukin‐17 Blockade With Secukinumab in Peripheral Spondyloarthritis Impacts Synovial Immunopathology Without Compromising Systemic Immune Responses

Autor: Nataliya Yeremenko, Inka A. Fluri, Talia E. Latuhihin, Henriëtte M. de Jong, Leonieke J J van Mens, S. Menegatti, Marleen G H van de Sande, Lars Rogge, Sijia Chen, Iris C Blijdorp, Dominique Baeten, Arno W R van Kuijk

Publikováno v: Arthritis & rheumatology
Arthritis & rheumatology, Wiley, 2018, 70 (12), pp.1994-2002. ⟨10.1002/art.40581⟩
Arthritis & rheumatology, 2018, 70 (12), pp.1994-2002. ⟨10.1002/art.40581⟩
Arthritis & rheumatology (Hoboken, N.J.), 70(12), 1994-2002. John Wiley and Sons Ltd

International audience; Objective: Secukinumab (anti-interleukin-17A [anti-IL-17A]) is an effective therapy for ankylosing spondylitis and psoriatic arthritis, the prototypical forms of spondyloarthritis (SpA). We undertook this study to determine wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfc500aa111627000f3e90243134513
https://hal-pasteur.archives-ouvertes.fr/pasteur-02650790

HLA-C*07 in axial spondyloarthritis: data from the German Spondyloarthritis Inception Cohort and the Spondyloarthritis Caught Early cohort

Autor: Janneke J. de Winter, Iris C. Blijdorp, Henriëtte M. de Jong, Jürgen Sauter, Alexander H. Schmidt, Floris A. van Gaalen, Désirée van der Heijde, Denis Poddubnyy, Nataliya G. Yeremenko, Marleen G. van de Sande, Dominique L. Baeten

Publikováno v: Genes and Immunity, 20(8), 671-677. NATURE PUBLISHING GROUP
Genes and immunity, 20(8), 671-677. Nature Publishing Group

We aimed to assess the mRNA expression of MHC class 1-related molecules in ankylosing spondylitis (AS) patients vs healthy controls (HCs) and, subsequently, if the absence of HLA-C*07 is associated with genetic susceptibility to axial spondyloarthrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ec01a60cb5b8a3a3e5c30b6f428958
https://pubmed.ncbi.nlm.nih.gov/31068685