Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Iris Alroy"'
Autor:
Emma J Brasell, Lee Lee Chu, Murielle M Akpa, Idit Eshkar-Oren, Iris Alroy, Rachel Corsini, Brian M Gilfix, Yojiro Yamanaka, Pedro Huertas, Paul Goodyer
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0223954 (2019)
BACKGROUND:Cystinosis is a rare disorder caused by recessive mutations of the CTNS gene. Current therapy decreases cystine accumulation, thus slowing organ deterioration without reversing renal Fanconi syndrome or preventing eventual need for a kidne
Externí odkaz:
https://doaj.org/article/2e84c7d37c0c4e8c98cac65eefed847d
Autor:
Lilach Vaks, Dana Litvak-Greenfeld, Stav Dror, LeeRon Shefet-Carasso, Galia Matatov, Limor Nahary, Shiran Shapira, Rahely Hakim, Iris Alroy, Itai Benhar
Publikováno v:
Antibodies, Vol 7, Iss 3, p 27 (2018)
Bispecific antibodies (bsAbs) are antibodies with two binding sites directed at different antigens, enabling therapeutic strategies not achievable with conventional monoclonal antibodies (mAbs). Since bispecific antibodies are regarded as promising t
Externí odkaz:
https://doaj.org/article/b8e5a2a749c5447c9e18022c94bf9c22
Publikováno v:
Drug Discovery Today. 26:786-793
Multiple layers of regulation are in place on mRNA translation to ensure that cells respond in a fast manner to environmental cues in a tissue-specific and mRNA-selective manner. Here, we discuss mRNA translation regulatory mechanisms and potential d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f991ef4ec5982ed766924fa7c1821a
https://doi.org/10.1016/j.drudis.2020.11.017
https://doi.org/10.1016/j.drudis.2020.11.017
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:264-272
ELX-02 is a clinical stage, small-molecule eukaryotic ribosomal selective glycoside acting to induce read-through of premature stop codons (PSCs) that results in translation of full-length protein. However, improved read-through at PSCs has raised th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fbdea65cbf43a9ab8f23b089e4686b
https://doi.org/10.1124/jpet.120.265595
https://doi.org/10.1124/jpet.120.265595
Publikováno v:
Protein Degradation with New Chemical Modalities ISBN: 9781788016865
Regulation of protein translation is not restricted to global coordination, but it is also highly specific as it is an important infliction point in the regulation of gene expression, because it offers a rapid and protein-selective response to enviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10c4b6644da675d021e16bf604b079e
https://doi.org/10.1039/9781839160691-00254
https://doi.org/10.1039/9781839160691-00254
Autor:
Lee Lee Chu, Yojiro Yamanaka, Iris Alroy, Brian M. Gilfix, Rachel Corsini, Murielle M. Akpa, Pedro Huertas, Idit Eshkar-Oren, Emma J. Brasell, Paul Goodyer
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0223954 (2019)
PLoS ONE
PLoS ONE
Background Cystinosis is a rare disorder caused by recessive mutations of the CTNS gene. Current therapy decreases cystine accumulation, thus slowing organ deterioration without reversing renal Fanconi syndrome or preventing eventual need for a kidne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7369c74917ec3d51f7ec9a8f0d9d42d2
https://doaj.org/article/2e84c7d37c0c4e8c98cac65eefed847d
https://doaj.org/article/2e84c7d37c0c4e8c98cac65eefed847d
Autor:
Stav Dror, Shiran Shapira, LeeRon Shefet-Carasso, Lilach Vaks, Limor Nahary, Itai Benhar, Rahely Hakim, Galia Matatov, Dana Litvak-Greenfeld, Iris Alroy
Publikováno v:
Antibodies
Volume 7
Issue 3
Antibodies, Vol 7, Iss 3, p 27 (2018)
Volume 7
Issue 3
Antibodies, Vol 7, Iss 3, p 27 (2018)
Bispecific antibodies (bsAbs) are antibodies with two binding sites directed at different antigens, enabling therapeutic strategies not achievable with conventional monoclonal antibodies (mAbs). Since bispecific antibodies are regarded as promising t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f74b09343c1bfdf6d5d59fe6376ffe
Publikováno v:
Molecular Genetics and Metabolism. 123:S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9bd1f885105f958acba4a78cf55d2d
https://doi.org/10.1016/j.ymgme.2017.12.020
https://doi.org/10.1016/j.ymgme.2017.12.020
Autor:
Yuval Reiss, Vivian Bicoviski, Omri Erez, Mally Dori-Bachash, Shmuel Tuvia, Danny Ben-Avraham, Iris Alroy, Daniel Taglicht, Iris Alchanati
Publikováno v:
The Journal of Cell Biology
The ubiquitin (Ub) domain protein Herp plays a crucial role in the maintenance of calcium homeostasis during endoplasmic reticulum (ER) stress. We now show that Herp is a substrate as well as an activator of the E3 Ub ligase POSH. Herp-mediated POSH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d446d24cad3c98c024577d9e9734502
https://doi.org/10.1083/jcb.200611036
https://doi.org/10.1083/jcb.200611036
Autor:
Mally Dori, Anat Nir, Shmuel Tuvia, Daniel N. Taglicht, Mordechai Koskas, Iris Alchanati, Oshrat Propheta-Meiran, Dalit Konforty, Haim Moskowitz, Revital Mandil-Levin, Uwe Tessmer, Iris Alroy, Yuval Reiss, Elanite Caspi-Bachar, Shenhav Cohen, Liora Yaar, Haim Barr, Tsvika Greener, Omri Erez, Alin Sela-Brown, Daphna Gordon, Danny Ben-Avraham, Ulrich S. Schubert, Vivian Bicoviski, Orit Levius
Publikováno v:
Proceedings of the National Academy of Sciences. 102:1478-1483
HIV type 1 (HIV-1) was shown to assemble either at the plasma membrane or in the membrane of late endosomes. Now, we report an essential role for human ubiquitin ligase POSH (Plenty of SH3s; hPOSH), a trans-Golgi network-associated protein, in the ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860963e7814103775db6021e3d81688d
https://doi.org/10.1073/pnas.0408717102
https://doi.org/10.1073/pnas.0408717102