Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Irinna Papangeli"'
Autor:
Saejeong Park, Zhiyuan Ma, Georgia Zarkada, Irinna Papangeli, Sarin Paluri, Nour Nazo, Felix Rivera‐Molina, Derek Toomre, Sudarshan Rajagopal, Hyung J. Chun
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Modulation of endothelial cell behavior and phenotype by hemodynamic forces involves many signaling components, including cell surface receptors, intracellular signaling intermediaries, transcription factors, and epigenetic elements. Many of
Externí odkaz:
https://doaj.org/article/fb5e7074c9564817987662362c67b496
Autor:
Aram Lee, Irinna Papangeli, Youngsook Park, Ha-neul Jeong, Jihea Choi, Hyesoo Kang, Ha-neul Jo, Jongmin Kim, Hyung J. Chun
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Activation of the endothelium by pro-inflammatory stimuli plays a key role in the pathogenesis of a multitude of vascular diseases. Angiogenesis is a crucial component of the vascular response associated with inflammatory signaling. The CD40
Externí odkaz:
https://doaj.org/article/c9d724390ac74109ab3a7959e35b8668
Autor:
Mark Chaffin, Irinna Papangeli, Bridget Simonson, Amer-Denis Akkad, Matthew C. Hill, Alessandro Arduini, Stephen J. Fleming, Michelle Melanson, Sikander Hayat, Maria Kost-Alimova, Ondine Atwa, Jiangchuan Ye, Kenneth C. Bedi, Matthias Nahrendorf, Virendar K. Kaushik, Christian M. Stegmann, Kenneth B. Margulies, Nathan R. Tucker, Patrick T. Ellinor
Publikováno v:
Nature. 608:174-180
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3953303da37730099f0ab2b5ff9e6a36
https://doi.org/10.1038/s41586-022-04817-8
https://doi.org/10.1038/s41586-022-04817-8
Autor:
Irinna Papangeli, Jongmin Kim, Inna Maier, Saejeong Park, Aram Lee, Yujung Kang, Keiichiro Tanaka, Omar F. Khan, Hyekyung Ju, Yoko Kojima, Kristy Red-Horse, Daniel G. Anderson, Arndt F. Siekmann, Hyung J. Chun
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
G protein-coupled receptors APLNR and CXCR4 are crucial for vascular development. Here, the authors show that these two signaling pathways communicate and that in response to blood flow APLNR signaling induces a decrease in CXCR4 expression via miR-1
Externí odkaz:
https://doaj.org/article/f8d99b3209af438b97ff65e526d3b632
Autor:
Heon-Woo Lee, Takaomi Adachi, Boryeong Pak, Saejeong Park, Xiaoyue Hu, Woosoung Choi, Piotr S Kowalski, C Hong Chang, Katharine R Clapham, Aram Lee, Irinna Papangeli, Jongmin Kim, Orjin Han, Jihwan Park, Daniel G Anderson, Michael Simons, Suk-Won Jin, Hyung J Chun
Publikováno v:
Cardiovascular research.
Aims Components of bone morphogenetic protein (BMP) signalling have been implicated in both pathogenesis of pulmonary arterial hypertension (PAH) and endothelial-mesenchymal transition (EndoMT). In particular, the importance of BMP type 2 receptor in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be629ef98349e5854fa5bb1f502928cd
https://pubmed.ncbi.nlm.nih.gov/36166408
https://pubmed.ncbi.nlm.nih.gov/36166408
Publikováno v:
Seminars in Perinatology. 42:487-500
Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex polygenic conditions. The repurposing of CRISPR/Cas9, an ancient bacterial immune defense system, into a gene-editing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b97a9bfe8a573e330cace8c24639c9
https://doi.org/10.1053/j.semperi.2018.09.003
https://doi.org/10.1053/j.semperi.2018.09.003
Autor:
Mark, Chaffin, Irinna, Papangeli, Bridget, Simonson, Amer-Denis, Akkad, Matthew C, Hill, Alessandro, Arduini, Stephen J, Fleming, Michelle, Melanson, Sikander, Hayat, Maria, Kost-Alimova, Ondine, Atwa, Jiangchuan, Ye, Kenneth C, Bedi, Matthias, Nahrendorf, Virendar K, Kaushik, Christian M, Stegmann, Kenneth B, Margulies, Nathan R, Tucker, Patrick T, Ellinor
Publikováno v:
Nature. 608(7921)
Heart failure encompasses a heterogeneous set of clinical features that converge on impaired cardiac contractile function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f97f4a16987cefc7247f8f3be3b4547b
https://pubmed.ncbi.nlm.nih.gov/35732739
https://pubmed.ncbi.nlm.nih.gov/35732739
Autor:
Kristin G. Ardlie, Nathan R. Tucker, Kenneth B. Margulies, Carolina Roselli, Seung Hoan Choi, Victoria A. Parsons, Christian Stegmann, Caroline N. Herndon, Amelia W. Hall, Patrick T. Ellinor, Stephen J. Fleming, Amer-Denis Akkad, Alessandro Arduini, Mehrtash Babadi, Kenneth Bedi, Irinna Papangeli, François Aguet, Mark Chaffin
Publikováno v:
Circulation
Circulation, 142(5), 466-482. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 142(5), 466-482. LIPPINCOTT WILLIAMS & WILKINS
Background: The human heart requires a complex ensemble of specialized cell types to perform its essential function. A greater knowledge of the intricate cellular milieu of the heart is critical to increase our understanding of cardiac homeostasis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e592b598e80d271b900003e17c5d9c29
https://europepmc.org/articles/PMC7666104/
https://europepmc.org/articles/PMC7666104/
Autor:
Serpil C. Erzurum, Suzy A. A. Comhair, Hyung J. Chun, Takaomi Adachi, Irinna Papangeli, Cheol Hwangbo, John J. Schwarz, Avraham Sofer, Seyoung Lee, Paul DaSilva-Jardine, Jongmin Kim
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 198:1345-1348
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27383659ff670e38fb3b507148d20794
https://doi.org/10.1164/rccm.201805-0817le
https://doi.org/10.1164/rccm.201805-0817le
Autor:
Eun Mi Hwang, William P. Dunworth, Jean-Leon Thomas, Suk-Won Jin, Xiaoyue Hu, Omar El-Hely, Serpil C. Erzurum, Boryeong Pak, Suzy A. A. Comhair, Heon Lee, Hyung J. Chun, Cheol Hwangbo, Hyekyung Ju, Jun Dae Kim, Jinah Han, Laura A Peterson, Irinna Papangeli, Seyoung Lee, Victoria L. Bautch, Jae Yong Park, Avraham Sofer, Hyeseon Kang, David S. Wiley
Publikováno v:
Circulation. 135:2288-2298
Background: Bone morphogenetic protein (BMP) signaling has multiple roles in the development and function of the blood vessels. In humans, mutations in BMP receptor type 2 (BMPR2), a key component of BMP signaling, have been identified in the majorit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df5a2089ec54239e5737148b123216a8
https://doi.org/10.1161/circulationaha.116.025390
https://doi.org/10.1161/circulationaha.116.025390