Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Irini A. Doytchinova"'
Autor:
Irini A. Doytchinova, Darren R. Flower
Publikováno v:
BMC Immunology, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Cancer kills 8 million annually worldwide. Although survival rates in prevalent cancers continue to increase, many cancers have no effective treatment, prompting the search for new and improved protocols. Immunotherapy is a new and exciting
Externí odkaz:
https://doaj.org/article/5c6dbb57546044f39fc7eff9072daa6b
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224271 (2019)
Due to its high catalytic activity and readily available supply, ribonuclease A (RNase A) has become a pivotal enzyme in the history of protein science. Moreover, this great interest has carried over to computational chemistry and molecular dynamics,
Externí odkaz:
https://doaj.org/article/a5f81c433bc842ea8f2c019a7afda40c
Autor:
Nikola Ralchev Ralchev, Aleksandar Mishel Markovski, Inna Angelova Yankova, Iliyan Konstantinov Manoylov, Irini Atanas Doytchinova, Nikolina Mihaylova Mihaylova, Alexander Dimitrov Shinkov, Andrey Ivanov Tchorbanov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15083
Hashimoto’s thyroiditis is one of the most common endocrine disorders, affecting up to 20% of the adult population. No treatment or prevention exists except hormonal substitution for hypothyroidism. We hypothesize that it may be possible to selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0096d9e894fdf86ad1475707c4f1e69
Publikováno v:
Post-genomic Approaches in Drug and Vaccine Development ISBN: 9781003339090
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a1b0adf41f29f9ae707bbbbc4da9dba
https://doi.org/10.1201/9781003339090-9
https://doi.org/10.1201/9781003339090-9
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 409
Biological experiments often produce enormous amount of data, which are usually analyzed by data clustering. Cluster analysis refers to statistical methods that are used to assign data with similar properties into several smaller, more meaningful gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecef79487dc55711c81ac1d7207886a5
https://pubmed.ncbi.nlm.nih.gov/18449997
https://pubmed.ncbi.nlm.nih.gov/18449997
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 409
Quantitative structure-activity relationship (QSAR) analysis is a cornerstone of modern informatics. Predictive computational models of peptide-major histocompatibility complex (MHC)-binding affinity based on QSAR technology have now become important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25278262f07459d65db05f1d08e091db
https://pubmed.ncbi.nlm.nih.gov/18450004
https://pubmed.ncbi.nlm.nih.gov/18450004
Autor:
Christopher P, Toseland, Debra J, Clayton, Helen, McSparron, Shelley L, Hemsley, Martin J, Blythe, Kelly, Paine, Irini A, Doytchinova, Pingping, Guan, Channa K, Hattotuwagama, Darren R, Flower
Publikováno v:
Immunome Research
AntiJen is a database system focused on the integration of kinetic, thermodynamic, functional, and cellular data within the context of immunology and vaccinology. Compared to its progenitor JenPep, the interface has been completely rewritten and rede
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::578f41dd111102d3326e62c5b2e2abee
https://pubmed.ncbi.nlm.nih.gov/16305757
https://pubmed.ncbi.nlm.nih.gov/16305757
Autor:
Darren R, Flower, Irini A, Doytchinova
Publikováno v:
Applied bioinformatics. 1(4)
Immunoinformatics is the application of informatics techniques to molecules of the immune system. One of the key goals of immunoinformatics is the development of computer aided vaccine design (CAVD), or computational vaccinology, and its application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0f1c58f4dde18633a2d1f5d44bdbb3c
https://pubmed.ncbi.nlm.nih.gov/15130835
https://pubmed.ncbi.nlm.nih.gov/15130835
Autor:
Darren R, Flower, Helen, McSparron, Martin J, Blythe, Christianna, Zygouri, Debra, Taylor, Pingping, Guan, Shouzhan, Wan, Peter V, Coveney, Valerie, Walshe, Persephone, Borrow, Irini A, Doytchinova
Publikováno v:
Novartis Foundation symposium. 254
The immune system is hierarchical and has many levels, exhibiting much emergent behaviour. However, at its heart are molecular recognition events that are indistinguishable from other types of biomacromolecular interaction. These can be addressed wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e3de7351356b3bf92c6f20031f2ce07
https://pubmed.ncbi.nlm.nih.gov/14712934
https://pubmed.ncbi.nlm.nih.gov/14712934
Autor:
Irini A, Doytchinova, Darren R, Flower
Publikováno v:
Journal of computer-aided molecular design. 16(8-9)
The 3D-QSAR CoMSIA technique was applied to a set of 458 peptides binding to the five most widespread HLA-A2-like alleles: A*0201, A*0202, A*0203, A*0206 and A*6802. Models comprising the main physicochemical properties (steric bulk, electron density
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6aa1db3ef92cab6ca56c78f0e8ade3c
https://pubmed.ncbi.nlm.nih.gov/12602948
https://pubmed.ncbi.nlm.nih.gov/12602948