Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Irini Akritopoulou-Zanze"'
1
Akademický článek
Small Molecule Library Synthesis Using Segmented Flow
Autor: Christina M. Thompson, Stevan W. Djuric, Jeffrey L. Cross, Irini Akritopoulou-Zanze, Jennifer L. Poole
Publikováno v: Molecules, Vol 16, Iss 11, Pp 9161-9177 (2011)
Flow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this p
Externí odkaz: https://doaj.org/article/dcf7d238b71f4c36b97d242e10bb77bd
Zobrazit plný text záznamu
2
Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors
Autor: Anil Vasudevan, Ana Lucia Relo, Irini Akritopoulou-Zanze, Hongyu Zhao, Mario Mezler, Carolin Hoft, Willi Amberg, Frauke Pohlki, Ying Wang, Yi-Yin Ku, Justin D. Dietrich, Michael Ochse, Yanbin Lao, Huan-Qiu Li, Steven M. Hannick, Jason T. Brewer, Berthold Behl, Jens Sydor, Udo Lange, Wilfried Hornberger
Publikováno v: Journal of medicinal chemistry. 61(17)
The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. Herein, we report the synthesis and biological evaluation of aminotetralines and aminochromanes as novel classes of competitive GlyT1 inhibitors.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ef701eae6cddb134d20a7a01fca9f0
https://pubmed.ncbi.nlm.nih.gov/30080045
Zobrazit plný text záznamu
3
De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors
Autor: Udo Lange, Yanbin Lao, Wilfried Hornberger, Frauke Pohlki, Jens Sydor, Mario Mezler, Jason T. Brewer, Stevan W. Djuric, Berthold Behl, Irini Akritopoulou-Zanze, Justin D. Dietrich, Ana Lucia Relo, Hongyu Zhao, Carolin Hoft, Huan-Qiu Li, Ying Wang, Anil Vasudevan, Willi Amberg
Publikováno v: Journal of medicinal chemistry. 61(17)
The development of glycine transporter 1 (GlyT1) inhibitors may offer putative treatments for schizophrenia and other disorders associated with hypofunction of the glutaminergic N-methyl-d-aspartate (NMDA) receptor. Herein, we describe the synthesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1cbd37b4fe43579515c610b80749e6
https://pubmed.ncbi.nlm.nih.gov/29969029
Zobrazit plný text záznamu
7
Small Molecule Library Synthesis Using Segmented Flow
Autor: Irini Akritopoulou-Zanze, Stevan W. Djuric, Jennifer L. Poole, Christina M. Thompson, Jeffrey L. Cross
Publikováno v: Molecules
Molecules; Volume 16; Issue 11; Pages: 9161-9177
Molecules, Vol 16, Iss 11, Pp 9161-9177 (2011)
Flow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95535f21ee1b08d6d86ad1ef3f020fa
http://europepmc.org/articles/PMC6264587
Zobrazit plný text záznamu
8
Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions
Autor: Alan F. Gasiecki, Douglas Kalvin, Eric F. Johnson, Irini Akritopoulou-Zanze, Stevan W. Djuric, Brian D. Wakefield, Peter Kovar
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:1480-1483
We report the synthesis and biological evaluation of 5-substituted indazoles as kinase inhibitors. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing heterocycle forming and multicompone
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7b2b0181113f35782edd76d1263a2b
https://doi.org/10.1016/j.bmcl.2011.01.001
Zobrazit plný text záznamu
9
When analoging is not enough: scaffold discovery in medicinal chemistry
Autor: Irini Akritopoulou-Zanze, Hongyu Zhao
Publikováno v: Expert Opinion on Drug Discovery. 5:123-134
As an integral part of lead generation and optimization, scaffold discovery has broad implications in drug discovery. Currently available chemical scaffolds might be inadequate to provide drug-like ligands for new targets such as phosphatases and pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ff6d20452fe8c7d4d4a47e2ec292a7
https://doi.org/10.1517/17460440903584874
Zobrazit plný text záznamu
10
Synthesis of substituted fused pyridines, pyrazines and pyrimidines by sequential Ugi/inverse electron demand Diels–Alder transformations
Autor: Irini Akritopoulou-Zanze, Hongyu Zhao, Ying Wang, Stevan W. Djuric
Publikováno v: Tetrahedron Letters. 50:5773-5776
The synthesis of all four regioisomers of fused pyrrolidino-pyridines in a one-pot two-step sequential Ugi-inverse electron demand Diels–Alder reaction is described. Fused pyrrolidino-pyrazines, pyrrolidino-pyrimidines and azepinone pyridines can a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5820c9c889b87c84997c15922af7f780
https://doi.org/10.1016/j.tetlet.2009.07.036
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje