Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Irini, Abdiaj"'
Autor:
Irini, Abdiaj, Santiago, Cañellas, Alejandro, Dieguez, Maria Lourdes, Linares, Brenda, Pijper, Alberto, Fontana, Raquel, Rodriguez, Andres, Trabanco, Eduardo, Palao, Jesus, Alcázar
Publikováno v:
Journal of medicinal chemistry.
Herein, we report an end-to-end process including synthesis, work-up, purification, and post-purification with minimal human intervention using Negishi coupling as a key transformation to increase Fsp
Autor:
B. Frank Gupton, Justina M. Burns, Rudy Krack, David R. Snead, Ryan C Nelson, D. Tyler McQuade, Irini Abdiaj, Vijayagopal Gopalsamuthiram, Rodger W. Stringham, Saeed Ahmad
Publikováno v:
Organic Process Research & Development
An economical synthesis of lamivudine was developed by employing a new method to establish the stereochemistry about the heterocyclic oxathiolane ring. Toward this end, an inexpensive and readily accessible lactic acid derivative served the dual purp
Publikováno v:
Journal of Flow Chemistry. 10:73-92
The signature benefits of continuous flow are largely a result of a reactor’s micro-sized features. However, as the technology gains industrial traction in the synthesis of active pharmaceutical ingredients (API), the reactors must be scaled to lar
Autor:
Eli Zysman-Colman, Xiao-Jing Wei, Chenfei Li, Irini Abdiaj, Carlo Sambiagio, Timothy Noël, Jesús Alcázar
Publikováno v:
Angewandte Chemie-International Edition, 58(37), 13030-13034. Wiley
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
X.-J.W., I.A., J.A., and T.N. would like to acknowledge the European Union for a Marie Curie ITN Grant (Photo4Future, Grant No. 641861). C.S. acknowledges the European Union for a Marie Curie European post-doctoral fellowship (FlowAct, Grant No. 7940
Autor:
Juliana M. de Souza, Kenneth Hanson, Kleber T. de Oliveira, Jiaqi Chen, D. Tyler McQuade, Irini Abdiaj
Publikováno v:
Org Biomol Chem
Numerous methodologies to obtain pyridines from ylidenemalononitriles are described in the literature. Nevertheless, they are limited to the use of microwave or conventional heat and few lead to 2, 3, 4 or 2, 3, 4, 5-substituted pyridines as multi-pr
Autor:
Irini Abdiaj, Paul G. Richardson
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783030855918
The spiraling costs, competitive nature, and stringent timelines associated with Drug Discovery fuel investigations into new technologies that can potentially alleviate the pressures associated with these factors. Whereas advantages of the implementa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::074ef1e594cac9e221cf96ad1b04dd7d
https://doi.org/10.1007/7355_2021_135
https://doi.org/10.1007/7355_2021_135
Autor:
Jiaqi Chen, Kleber T. de Oliveira, Kenneth Hanson, Juliana M. de Souza, Irini Abdiaj, D. Tyler McQuade
Publikováno v:
The Journal of organic chemistry. 85(18)
Recently, we demonstrated that ylidenemalononitriles (YMs) react with amines to form cyclic amidines and that the starting linear YMs are nonemissive in solution and the cyclic amidines are fluorescent. These turn-on systems were of interest to us be
Publikováno v:
The Journal of Organic Chemistry
The scale up of light-induced nickel-catalyzed Negishi reactions is reported herein, with output rates reaching multigram quantities per hour. This level of throughput is suitable to support preclinical medicinal chemistry programs in late lead optim
Autor:
Jesús Alcázar, Irini Abdiaj
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6190-6196
We report herein the transfer of dual photoredox and nickel catalysis for C(sp2)C(sp3) cross coupling form batch to flow. This new procedure clearly improves the scalability of the previous batch reaction by the reactor's size and operating time redu
Autor:
José R. Carrillo, Cecilia Bottecchia, Jesús Orduna, Jesús Alcázar, Ettore Crovini, Raúl Martín, Irini Abdiaj, María Jesús Blesa, Timothy Noël, Pilar Prieto
Publikováno v:
Advanced Synthesis & Catalysis, 361(5), 945-950. Wiley-VCH Verlag
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC
Advanced Synthesis & Catalysis
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC
Advanced Synthesis & Catalysis
Herein, we report the de novo synthesis and characterization of a series of substituted bithiophene derivatives as novel and inexpensive organic photocatalysts. DFT calculations were used to predict a priori their absorption spectra and redox potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eb015dd0bd13cbc85546047191e043
https://research.tue.nl/nl/publications/361168ac-f1bd-4621-bed1-f6af25308d0b
https://research.tue.nl/nl/publications/361168ac-f1bd-4621-bed1-f6af25308d0b