Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Irine Khutsishvili"'
Publikováno v:
Biophysical Journal. 121:4892-4899
High hydrostatic pressure can have profound effects on the stability of biomacromolecules. The magnitude and direction (stabilizing or destabilizing) of this effect is defined by the volume changes in the system, ΔV. Positive volume changes will sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66bd76b6fb2a8cbf9103cedb767ad07
https://doi.org/10.1016/j.bpj.2022.08.005
https://doi.org/10.1016/j.bpj.2022.08.005
Autor:
Suravi Pramanik, Yingling Chen, Heyu Song, Irine Khutsishvili, Luis A Marky, Sutapa Ray, Amarnath Natarajan, Pankaj K Singh, Kishor K Bhakat
Publikováno v:
Nucleic Acids Research. 50:3394-3412
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich region in KRAS promoter can fold into a four-stranded DNA secondary struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bbf12da443c169932ab3847f1e47d3
https://doi.org/10.1093/nar/gkac172
https://doi.org/10.1093/nar/gkac172
Publikováno v:
The Journal of Physical Chemistry B. 121:9175-9184
We report the thermodynamic contributions of loop length and loop sequence to the overall stability of DNA intramolecular pyrimidine triplexes. Two sets of triplexes were designed: in the first set, the C5 loop closing the triplex stem was replaced w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d870c1572a1ef237cd6ce930e587a4
https://doi.org/10.1021/acs.jpcb.7b07591
https://doi.org/10.1021/acs.jpcb.7b07591
Autor:
Calliste Reiling-Steffensmeier, Chris M. Olsen, Luis A. Marky, Sarah Johnson, Irine Khutsishvili, Rajkumar Ganugula, Ronald A. Shikiya
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:990-998
Background The overall stability of DNA molecules globally depends on base-pair stacking, base-pairing, polyelectrolyte effect and hydration contributions. In order to understand how they carry out their biological roles, it is essential to have a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a695c0b2cfe53ba7749e647dd8df5f0
https://doi.org/10.1016/j.bbagen.2015.10.002
https://doi.org/10.1016/j.bbagen.2015.10.002
Publikováno v:
Laser Physics Letters. 17:115602
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e652e2dd45280b4c9c99b793826ce22
https://doi.org/10.1088/1612-202x/abafbc
https://doi.org/10.1088/1612-202x/abafbc
Publikováno v:
Biophysical Journal. 118:66a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07f2fe00be246e281a443f7543baa214
https://doi.org/10.1016/j.bpj.2019.11.534
https://doi.org/10.1016/j.bpj.2019.11.534
Publikováno v:
European Chemical Bulletin. 9:22
The main goals of the research are to study the drug delivery nanoparticle, G4 PAMAM (polyamidoamine) dendrimer, using spectroscopic and thermodynamic methods and, based on the unique properties of G4 PAMAM dendrimer, create new, stable nano-sized (~
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6edef88155db7e6695205e5688ef280c
https://doi.org/10.17628/ecb.2020.9.22-27
https://doi.org/10.17628/ecb.2020.9.22-27
Publikováno v:
The journal of physical chemistry. B. 122(28)
Triplex formation occurs via interaction of a third strand with the major groove of double-stranded nucleic acid, through Hoogsteen hydrogen bonding. In this work, we use a combination of temperature-dependent UV spectroscopy and differential scannin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbacd77d8100361ddbbe8dcb1e7087f2
https://pubmed.ncbi.nlm.nih.gov/29932334
https://pubmed.ncbi.nlm.nih.gov/29932334
Publikováno v:
The Journal of Physical Chemistry B. 119:1939-1946
Pseudoknots have diverse and important roles in many biological functions. We used a combination of UV spectroscopy and differential scanning calorimetry to investigate the effect of the loop length on the unfolding thermodynamics of three sets of DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5a76c994853f54fbb6d1722e1ae8c5
https://doi.org/10.1021/jp5116417
https://doi.org/10.1021/jp5116417
Autor:
Irine Khutsishvili, Tamar G. Giorgadze, Temur B. Khuskivadze, Vasil G. Bregadze, Zaza G. Melikishvili
Publikováno v:
Advanced Techniques in Biology & Medicine.
The aim of this work is to demonstrate the significance of the phenomena of light re-radiation and the electron excitation energy transfer from the donor to the acceptor in the hydrolysis reactions of glycoside and phosphodiester bonds in DNA, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::576f7e35cae6f60afda45028d0a543d7
https://doi.org/10.4172/2379-1764.1000215
https://doi.org/10.4172/2379-1764.1000215