B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer’s Patches

Autor: Adi Biram, Eitan Winter, Alice E. Denton, Irina Zaretsky, Bareket Dassa, Mats Bemark, Michelle A. Linterman, Gur Yaari, Ziv Shulman

Publikováno v: Cell Reports, Vol 30, Iss 6, Pp 1910-1922.e5 (2020)

Summary: Antibodies secreted within the intestinal tract provide protection from the invasion of microbes into the host tissues. Germinal center (GC) formation in lymph nodes and spleen strictly requires SLAM-associated protein (SAP)-mediated T cell

Externí odkaz: https://doaj.org/article/6dc1f77208d54ea8b19bc44966092cbb

Substrate-bound CCL21 and ICAM1 combined with soluble IL-6 collectively augment the expansion of antigen-specific murine CD4+ T cells

Autor: Shimrit Adutler-Lieber, Irina Zaretsky, Helena Sabany, Elena Kartvelishvily, Ofra Golani, Benjamin Geiger, Nir Friedman

Publikováno v: Blood Advances, Vol 1, Iss 15, Pp 1016-1030 (2017)

Abstract: Immune processes within the complex microenvironment of the lymph node involve multiple intercellular, cell-matrix, and paracrine interactions, resulting in the expansion of antigen-specific T cells. Inspired by the lymph node microenvironm

Externí odkaz: https://doaj.org/article/89fdfe6693e346a4bebf6fbece1d2f3a

ICAMs support B cell interactions with T follicular helper cells and promote clonal selection

Autor: Irina Zaretsky, Alexander D. Gitlin, Liat Stoler-Barak, Adi Biram, Sara W. Feigelson, Ziv Shulman, Roei D Mazor, Britta Engelhardt, Ofir Atrakchi

Publikováno v: The Journal of Experimental Medicine
Zaretsky, Irina; Atrakchi, Ofir; Mazor, Roei D; Stoler-Barak, Liat; Biram, Adi; Feigelson, Sara W; Gitlin, Alexander D; Engelhardt, Britta; Shulman, Ziv (2017). ICAMs support B cell interactions with T follicular helper cells and promote clonal selection. The Journal of experimental medicine, 214(11), pp. 3435-3448. Rockefeller Univ. Press 10.1084/jem.20171129

The molecular mechanism governing affinity-based B cell selection for germinal center colonization is unclear. Zaretsky et al. show that B cell ICAMs promote efficient B cell selection for clonal expansion by supporting sustained interactions with T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73eb744078632314e9fb16ba9ff70e03
https://doi.org/10.1084/jem.20171129

Diverse continuum of CD4+ T-cell states is determined by hierarchical additive integration of cytokine signals

Autor: Inbal Eizenberg-Magar, Irina Zaretsky, David Lara-Astiaso, Shlomit Reich-Zeliger, Jacob Rimer, Nir Friedman

During cell differentiation, progenitor cells integrate signals from their environment that guide their development into specialized phenotypes. The ways by which cells respond to complex signal combinations remain difficult to analyze and model. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e324a0304232f4572ae80cf77efc6c09
https://europepmc.org/articles/PMC5547583/

Dynamic single-cell measurements of gene expression in primary lymphocytes: challenges, tools and prospects

Autor: Michal Polonsky, Irina Zaretsky, Nir Friedman

Publikováno v: Briefings in Functional Genomics

Lymphocyte populations show a high level of phenotypic variability and are highly heterogeneous in their gene expression patterns. Studying this cell-to-cell variability, the processes which generate it and its implications for lymphocyte function ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2025b73c921c24822c9b7a49c5ea44
https://doi.org/10.1093/bfgp/els061