Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Irina Y Sazonova"'
Embolic Stroke Diagnosed by Elevated D-Dimer in a Patient With Negative TEE for Cardioembolic Source
Autor:
Irina Y. Sazonova PhD, Roja Pondicherry-Harish MD, Nikhil Kadle BS, Gyanendra K. Sharma MD, Ramon E. Figueroa MD, Vincent J. B. Robinson MD
Publikováno v:
Journal of Investigative Medicine High Impact Case Reports, Vol 2 (2014)
We report a case of cerebrovascular accident with thromboembolic stroke etiology in a patient who had atrial flutter and negative transesophageal echocardiography (TEE) results. The increased D-dimer levels (1877 ng/mL) initiated referral for magneti
Externí odkaz:
https://doaj.org/article/6c6a48854dbe432f9a04bb32d20535ff
Autor:
Irina Y Sazonova, S. Sibel Erdem, Jason R. McCarthy, Purvish Patel, Farouc A. Jaffer, Ion Botnaru, Charles P. Lin, Tetsuya Hara, Guy L. Reed, Brian Thompson, Ralph Weissleder
Publikováno v:
Nanomedicine. 7:1017-1028
Background: Current thrombolytic therapies utilize exogenous plasminogen activators (PAs) to effectively lyse clots, restoring blood flow, and preventing tissue and organ death. These PAs may also impair normal hemostasis, leading to life-threatening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeab20e321342f56561c245c37e986da
https://doi.org/10.2217/nnm.11.179
https://doi.org/10.2217/nnm.11.179
Autor:
David C. Hess, Irina Y Sazonova, Adviye Ergul, Daniel C. Wiley, Azza B. El-Remessy, Susan C. Fagan, Anna Kozak, Livia S. Machado, Jennifer L. Waller
Publikováno v:
Stroke. 40:3028-3033
Background and Purpose— New treatment strategies for acute ischemic stroke must be evaluated in the context of effective reperfusion. Minocycline is a neuroprotective agent that inhibits proteolytic enzymes and therefore could potentially both inac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfcbe310541dc3a06271b8aa7ec0d29c
https://doi.org/10.1161/strokeaha.109.556852
https://doi.org/10.1161/strokeaha.109.556852
Publikováno v:
Journal of Thrombosis and Haemostasis. 5:2087-2094
Summary. α2-antiplasmin (α2-AP) is the fast serpin inhibitor of plasmin and appears to limit the success of treatment for thrombosis. We examined the mechanisms through which monoclonal antibodies (mAbs) against α2-AP amplify fibrinolysis. The mAb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2adf590b778d4343e14df625f57d1b6
https://doi.org/10.1111/j.1538-7836.2007.02652.x
https://doi.org/10.1111/j.1538-7836.2007.02652.x
Autor:
Kathleen M Buckley, Md. N Hoda, Galina Kondrikova, Irina Y Sazonova, David C Hess, Patricia V Schoenlein, William D Hill
Publikováno v:
Stroke. 46
Background and Purpose: Previous literature and studies from our laboratory indicate that pharmacological inhibition and enhancement of autophagy are both effective in reducing infarct volume after stroke injury. Methods: Mice were treated with rapam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb87fa6e658f2bc11ac4562784614d2
https://doi.org/10.1161/str.46.suppl_1.tp79
https://doi.org/10.1161/str.46.suppl_1.tp79
Publikováno v:
Journal of Biological Chemistry. 279:24994-25001
The mechanism of action of plasminogen (Pg) activators may affect their therapeutic properties in humans. Streptokinase (SK) is a robust Pg activator in physiologic fluids in the absence of fibrin. Deletion of a "catalytic switch" (SK residues 1-59),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2979f7bdd046caec1022306e377c7a
https://doi.org/10.1074/jbc.m400253200
https://doi.org/10.1074/jbc.m400253200
Publikováno v:
Proceedings of the National Academy of Sciences. 100:9168-9172
The generation of plasmin by plasminogen (Pg) activators (PAs) is a physiologic process in animals that dissolves blood clots and promotes wound healing, blood vessel growth, and the migration of normal and cancerous cells. Pathogenic bacteria have e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978aca5a26611eeef22b09c78a10616
https://doi.org/10.1073/pnas.1631716100
https://doi.org/10.1073/pnas.1631716100
Autor:
Sudharsan Periyasamy-Thandavan, Kathleen M. Buckley, Harrison E. Grace, John R Barrett, Galina Kondrikova, David C. Hess, Patricia V. Schoenlein, Daniel L Hess, Irina Y Sazonova, Russell C. Kirks, Nasrul Hoda, William D. Hill, Maribeth H. Johnson
Publikováno v:
Experimental & Translational Stroke Medicine
Background and purpose The role of autophagy in response to ischemic stroke has been confusing with reports that both enhancement and inhibition of autophagy decrease infarct size and improve post-stroke outcomes. We sought to clarify this by compari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb7e2d518a309465a2d34de53fe8f80
https://doi.org/10.1186/2040-7378-6-8
https://doi.org/10.1186/2040-7378-6-8
Autor:
Jennifer L. Waller, Gian Luigi Gigli, David C. Hess, Jeffrey A. Switzer, Francesco Janes, Irina Y Sazonova, Julia E. Brittain, Roberta Giacomello
Publikováno v:
Stroke. 45
Background: The cornerstone of acute stroke therapy is intravenous rt-PA, with the goal of rapid thrombolysis and restoration of blood flow. Unfortunately, less than half of patients treated have a favorable outcome. Since recanalization is closely c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ecff5cf44602ab08fcb76df558d5c2f
https://doi.org/10.1161/str.45.suppl_1.tmp20
https://doi.org/10.1161/str.45.suppl_1.tmp20
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c1c6437a90329e4bc3179fbca36fd6
https://doi.org/10.1096/fasebj.27.1_supplement.662.13
https://doi.org/10.1096/fasebj.27.1_supplement.662.13