Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Irina Voronov"'
Autor:
Andrew Wang, Luciene R. Carraro-Lacroix, Celeste Owen, Bowen Gao, Paul N. Corey, Pascal Tyrrell, John H. Brumell, Irina Voronov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Mammalian target of rapamycin (mTOR) is activated by numerous stimuli, including amino acids and growth factors. This kinase is part of the mTOR complex 1 (mTORC1) which regulates cell proliferation, differentiation, and autophagy. Active mT
Externí odkaz:
https://doaj.org/article/48c316c68a3b41edb20300c3142b91c4
Autor:
Morris F. Manolson, Yeqi Yao, Lucie Dupuis, Irina Voronov, Roberto Mendoza-Londono, Andrew Wang, Joerg Krueger, Ralph A Zirngibl
Publikováno v:
Journal of Cellular Biochemistry. 120:17180-17193
Autosomal recessive osteopetrosis (ARO) is a severe genetic bone disease characterized by high bone density due to mutations that affect formation or function of osteoclasts. Mutations in the a3 subunit of the vacuolar-type H+ -ATPase (encoded by T-c
Autor:
Irina Voronov, Bowen Gao, Paul Corey, John H. Brumell, Luciene R. Carraro-Lacroix, Pascal N. Tyrrell, Andrew Wang, Celeste Owen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Mammalian target of rapamycin (mTOR) is activated by numerous stimuli, including amino acids and growth factors. This kinase is part of the mTOR complex 1 (mTORC1) which regulates cell proliferation, differentiation, and autophagy. Active mTORC1 is l
Autor:
Elena Bajenova, Andrew Wang, John H. Brumell, Yingwei Hu, Celeste Owen, Irina Voronov, Paul Corey, Luciene R. Carraro-Lacroix
Publikováno v:
Journal of Cellular Biochemistry. 117:413-425
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in the regulation of cell growth. It has been shown to play an important role in osteoclast differentiation, particularly at the earlier stages of osteoclastogenesis. mTOR act
Autor:
Irina Voronov, Ralph A Zirngibl
Publikováno v:
Stem Cell Biology and Regenerative Medicine ISBN: 9783319981451
Evolutionary conserved kinase mechanistic target of rapamycin (mTOR) is the signaling hub for cellular responses to nutrients, cytokines, growth hormones, and environmental stresses in all eukaryotic cells. Increased mTOR activity has been demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a93cc360204893ced16b1a588756fcf
https://doi.org/10.1007/978-3-319-98146-8_5
https://doi.org/10.1007/978-3-319-98146-8_5
Autor:
Irina Voronov, Danielle E Johnson, Lisa Johnson, Bernhard Ganss, Ralph A Zirngibl, Grace Bradley, Andrew Wang, Celeste Owen
Publikováno v:
Journal of cellular biochemistry. 118(10)
Vacuolar H+ -ATPases (V-ATPases) are ubiquitous multisubunit proton pumps responsible for organellar pH maintenance. Mutations in the a3 subunit of V-ATPases cause autosomal recessive osteopetrosis, a rare disease due to impaired bone resorption. Pat
Publikováno v:
Proceedings of the Estonian Academy of Sciences, Vol 71, Iss 3, Pp 289-306 (2022)
The main goal of insurance company management is to increase shareholdersâ value and implement a strategy that promotes sustainable growth of the company. Well-known possible measures intended to achieve that goal are as follows: share price, econom
Externí odkaz:
https://doaj.org/article/9ba9c2dd61804dd0828b883bb8142ec0
Publikováno v:
Journal of Cellular Biochemistry. 114:2823-2833
Vacuolar-type H(+)-ATPases (V-ATPases) are located in lysosomes and at the ruffled border in osteoclasts. We showed previously that the R740S mutation is dominant negative for V-ATPase activity, uncouples proton transport from ATP hydrolysis and caus
Autor:
Morris F. Manolson, Celeste Owen, Irina Voronov, Jane E. Aubin, Noelle Ochotny, Valentin Jaumouillé
Publikováno v:
Journal of Bone and Mineral Research. 28:108-118
Vacuolar H+-ATPase (V-ATPase), a multisubunit enzyme located at the ruffled border and in lysosomes of osteoclasts, is necessary for bone resorption. We previously showed that heterozygous mice with an R740S mutation in the a3 subunit of V-ATPase (+/
Autor:
Irina Voronov
Publikováno v:
Oral diseases. 22(3)
DEL-1 is an endothelial cell-secreted protein that regulates LFA-1-integrin–dependent leukocyte recruitment and inflammation in various tissues. Here we identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we showed