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Whole-Body Distribution and Radiation Dosimetry of 11C-(+)-PHNO, a D2/3 Agonist Ligand

Autor: Alvina Ng, Alan A. Wilson, Peter M. Bloomfield, Pablo Rusjan, Romina Mizrahi, Irina Vitcu, Sylvain Houle

Publikováno v: Journal of Nuclear Medicine. 53:1802-1806

Using PET, we measured the whole-body distribution of 11C-(+)-PHNO (11C-(+)-4-propyl-9-hydroxynaphthoxazine), a D2/3 agonist, as a function of time in adult subjects in order to determine the internal radiation dose. Methods: PET whole-body data were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e09fa9684bc0fdd5cefedd7a4c76efc
https://doi.org/10.2967/jnumed.112.105627

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Biodistribution and Radiation Dosimetry of the Serotonin 5-HT6 Ligand [11C]GSK215083 Determined from Human Whole-Body PET

Autor: William A. Hallett, Marc Laruelle, Robert A. Comley, Alvina Ng, Sylvain Houle, Alan A. Wilson, Nicholas Keat, Cristian Salinas, Irina Vitcu, Eugenii A. Rabiner, Romina Mizrahi

Publikováno v: Molecular Imaging and Biology. 14:517-521

We measured the whole-body distribution of IV-injected [11C]GSK215083, a new 5-HT6 antagonist PET tracer, as a function of time in adult subjects, in order to determine the radiation exposure. After injection with a single bolus of [11C]GSK215083 (ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56c396cfaa7d38b1e88c13edb426e02f
https://doi.org/10.1007/s11307-011-0523-1

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Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [18F]-FEPPA and Positron Emission Tomography

Autor: Peter M. Bloomfield, Pablo Rusjan, Irina Vitcu, Romina Mizrahi, Jeffrey H. Meyer, Sylvain Houle, Alan A. Wilson

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 31:1807-1816

This article describes the kinetic modeling of [18F]-FEPPA binding to translocator protein 18 kDa in the human brain using high-resolution research tomograph (HRRT) positron emission tomography. Positron emission tomography scans were performed in 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341ab6658c1da18a3bff37a3fc03d659
https://doi.org/10.1038/jcbfm.2011.55

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Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans

Autor: Philip Seeman, Irina Vitcu, Pablo Rusjan, Romina Mizrahi, David C. Mamo, Shitij Kapur, Ariel Graff-Guerrero, Nathalie Ginovart, Alan A. Wilson, Matthaeus Willeit

Publikováno v: Hum Brain Mapp
Human Brain Mapping, Vol. 29, No 4 (2008) pp. 400-10

The D(2) receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [(11)C]‐(+)‐PHNO is a PET

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32f0ad0e12b49b20efe3f2ed646ada6
https://doi.org/10.1002/hbm.20392

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Separate brain regions code for salience vs. valence during reward prediction in humans

Autor: Irina Vitcu, Shitij Kapur, Jimmy Jensen, Adrian P. Crawley, Matthäus Willeit, David J. Mikulis, Andrew J. A. Smith

Publikováno v: Hum Brain Mapp

Predicting rewards and avoiding aversive conditions is essential for survival. Recent studies using computational models of reward prediction implicate the ventral striatum in appetitive rewards. Whether the same system mediates an organism's respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9aebfa4054aaaa7d7d6be3aeb67eb9
https://doi.org/10.1002/hbm.20274

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Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase

Autor: Junchao Tong, Irina Vitcu, Pablo Rusjan, Romina Mizrahi, Isabelle Boileau, Alan A. Wilson, Asfandyar Mufti, Stephen J. Kish, Sylvain Houle, Peter M. Bloomfield

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 55(12)

1993 Objectives To determine by a national survey: 1) the frequency of detection by public screening facilities of radioactivity in patients (pts) who had been treated with 131I for differentiated thyroid cancer (DTC), 2) the types and frequency of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7ed924494626c53c80aebd2edb251f
https://pubmed.ncbi.nlm.nih.gov/25413137

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Whole body biodistribution and radiation dosimetry in humans of a new PET ligand, [(18)F]-FEPPA, to image translocator protein (18 kDa)

Autor: Romina Mizrahi, Sylvain Houle, Irina Vitcu, Pablo Rusjan, Alvina Ng, Peter M. Bloomfield, Alan A. Wilson

Publikováno v: Molecular imaging and biology. 15(3)

[(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism.[(18)F]-FEPPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f5123a21074de16ffc20363f88400f
https://pubmed.ncbi.nlm.nih.gov/22895910

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Biodistribution and radiation dosimetry of the serotonin 5-HT₆ ligand [¹¹C]GSK215083 determined from human whole-body PET

Autor: Robert A, Comley, Cristian, Salinas, Romina, Mizrahi, Irina, Vitcu, Alvina, Ng, William, Hallett, Nicholas, Keat, Alan A, Wilson, Eugenii A, Rabiner, Marc, Laruelle, Sylvain, Houle

Publikováno v: Molecular imaging and biology. 14(4)

We measured the whole-body distribution of IV-injected [¹¹C]GSK215083, a new 5-HT₆ antagonist PET tracer, as a function of time in adult subjects, in order to determine the radiation exposure.After injection with a single bolus of [¹¹C]GSK21508

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fec9ce60d002dc0f9096041fa34e6ed4
https://pubmed.ncbi.nlm.nih.gov/22076076

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Side effects profile in humans of (11)C-(+)-PHNO, a dopamine D(2/3) agonist ligand for PET

Autor: Sylvain Houle, Alvina Ng, Alan A. Wilson, Irina Vitcu, Romina Mizrahi

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 51(3)

TO THE EDITOR: 11C-(+)-4-propyl-9-hydroxynaphthoxazine ((+)-PHNO) is a new PET ligand developed by our group. Binding assays show that (+)-PHNO displays high affinity and selectivity for the D2 receptor ( [1][1] ). Recently, it has been noted that 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9780a50423ea53178d59c3a45730540
https://pubmed.ncbi.nlm.nih.gov/20150251

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