Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats

Autor: Boldizsár Czéh, Irina Vardya, Zsófia Varga, Fabia Febbraro, Dávid Csabai, Lena-Sophie Martis, Kristoffer Højgaard, Kim Henningsen, Elena V. Bouzinova, Attila Miseta, Kimmo Jensen, Ove Wiborg

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined t

Externí odkaz: https://doaj.org/article/1f9cec32c8334b099dd1944bec6da17a

The schizophrenia-associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice

Autor: Mads E. Hauberg, Kimmo Jensen, Anto P. Rajkumar, Ole Mors, Ernst-Martin Füchtbauer, Kim Fejgin, Jonatan Pallesen, Irina Vardya, Veerle Paternoster, Mads Dyrvig, Arne Mørk, Birgitte Lundsberg, Jane H. Christensen, Tue Fryland, Mette Nyegaard, Per Qvist, Anders D. Børglum, Jens R. Nyengaard, Michael Didriksen

Publikováno v: Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2017, ' The schizophrenia-associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice ', Biological Psychiatry, vol. 82, no. 1, pp. 62-76 . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2017, ' The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice ', Biological Psychiatry, vol. 82, no. 1, pp. 62-76 . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2016, ' The schizophrenia associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice ', Biological psychiatry . https://doi.org/10.1016/j.biopsych.2016.08.037

Background The schizophrenia-associated BRD1 gene encodes a transcriptional regulator whose comprehensive chromatin interactome is enriched with schizophrenia risk genes. However, the biology underlying the disease association of BRD1 remains specula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7197cdf2a824af3d701dbcabe7526cbc
https://vbn.aau.dk/da/publications/8469c96c-3ae2-4a7d-b7d0-ab3dd45c4d45

Cell Type–Specific GABAA Receptor–Mediated Tonic Inhibition in Mouse Neocortex

Autor: Kimmo Jensen, Zita Dósa, Irina Vardya, Kim Ryun Drasbek

Publikováno v: Journal of Neurophysiology. 100:526-532

Activity of extrasynaptic GABAA receptors mediating tonic inhibition is thought to play an important role for the excitability of the mammalian cerebral cortex. However, little is known about the cell type–specific expression of tonic inhibition in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c96fbad3539e3c4cb0f40381e466381
https://doi.org/10.1152/jn.01224.2007

Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression

Autor: Ove Wiborg, Kimmo Jensen, Magdalena N. Jayatissa, Irina Vardya, Jose Luis Nieto-Gonzalez, Mai Marie Holm, Kim Henningsen

Publikováno v: Holm, M M, Nieto-Gonzalez, J L, Vardya, I, Henningsen, K, Jayatissa, M N, Wiborg, O & Jensen, K 2011, ' Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression ', The Hippocampus, vol. 21, pp. 422-433 .
Aarhus University

In major depression, one line of research indicates that a dysfunctional GABAergic inhibitory system is linked to the appearance of depressive symptoms. However, as the mechanistic details of such GABAergic deficit are largely unknown, we undertook a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad8765e21b4c64ead7a5af71fc3b7d5
https://pure.au.dk/portal/da/publications/hippocampal-gabaergic-dysfunction-in-a-rat-chronic-mild-stress-model-of-depression(28c38bb0-d4fa-11de-a30a-000ea68e967b).html

Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus

Autor: Mai Marie Holm, Jose Luis Nieto-Gonzalez, Christian Bjerggaard Vaegter, Anders Nykjaer, Irina Vardya, Kimmo Jensen

Publikováno v: Holm, M M, Nieto-Gonzales, J L, Vardya, I, Vægter, C B, Nykjær, A & Jensen, K 2009, ' Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus ', Journal of Neuroscience, vol. 29, no. 40, pp. 12412-8 .
Aarhus University

Mature BDNF and its precursor proBDNF may both be secreted to exert opposite effects on synaptic plasticity in the hippocampus. However, it is unknown how proBDNF and mature BDNF affect the excitability of GABAergic interneurons and thereby regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e511172ef0416a7750242f17be22143
https://pure.au.dk/portal/da/publications/mature-bdnf-but-not-probdnf-reduces-excitability-of-fastspiking-interneurons-in-mouse-dentate-gyrus(d01ae110-2aa0-11de-aee0-000ea68e967b).html