Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Irina V. Kholodenko"'
Autor:
Daniel V. Kalinovsky, Irina V. Kholodenko, Elena V. Svirshchevskaya, Alexey V. Kibardin, Dmitry Yu. Ryazantsev, Fedor N. Rozov, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 8112-8125 (2023)
Oligomerization of antibody fragments via modification with polyethylene glycol (pegylation) may alter their function and properties, leading to a multivalent interaction of the resulting constructs with the target antigen. In a recent study, we gene
Externí odkaz:
https://doaj.org/article/bf8e0d4d6862409b924c8a06a327194f
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 11, Pp 5153-5172 (2022)
Over the past two decades, mesenchymal stem cells (MSCs) have shown promising therapeutic effects both in preclinical studies (in animal models of a wide range of diseases) and in clinical trials. However, the efficacy of MSC-based therapy is not alw
Externí odkaz:
https://doaj.org/article/4c262d6d699a47b897870af69e8627f1
Autor:
Irina V. Kholodenko, Alisa M. Gisina, Garik V. Manukyan, Alexander G. Majouga, Elena V. Svirshchevskaya, Roman V. Kholodenko, Konstantin N. Yarygin
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 8, Pp 3428-3443 (2022)
Mesenchymal stem cells (MSCs) have a pronounced therapeutic potential in various pathological conditions. Though therapeutic effects of MSC transplantation have been studied for a long time, the underlying mechanisms are still not clear. It has been
Externí odkaz:
https://doaj.org/article/3918c10bc8fe4f978309af30b046e0c6
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 3056 (2023)
Non-alcoholic steatohepatitis (NASH) is a serious public health issue associated with the obesity pandemic. Obesity is the main risk factor for the non-alcoholic fatty liver disease (NAFLD), which progresses to NASH and then to end-stage liver diseas
Externí odkaz:
https://doaj.org/article/be444ec3e9064481a0ee2ab73463c61c
Autor:
Konstantin N. Yarygin, Daria D. Namestnikova, Kirill K. Sukhinich, Ilya L. Gubskiy, Alexander G. Majouga, Irina V. Kholodenko
Publikováno v:
Cells, Vol 10, Iss 11, p 2997 (2021)
Animal model studies and first clinical trials have demonstrated the safety and efficacy of the mesenchymal stem cells’ (MSCs) transplantation in stroke. Intra-arterial (IA) administration looks especially promising, since it provides targeted cell
Externí odkaz:
https://doaj.org/article/b7afa2ef486749e995d051deb9667305
Autor:
Irina V. Kholodenko, Daniel V. Kalinovsky, Igor I. Doronin, Sergey M. Deyev, Roman V. Kholodenko
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique features of this type of cancer frequently hamper the process of determining clinical presentation and predicting therapy effectiveness. The tumor can spontaneou
Externí odkaz:
https://doaj.org/article/7a878fbc68be4d47be4cc03930ac72ef
Autor:
Irina V. Kholodenko, Daniel V. Kalinovsky, Elena V. Svirshchevskaya, Igor I. Doronin, Maria V. Konovalova, Alexey V. Kibardin, Tatyana V. Shamanskaya, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko
Publikováno v:
Molecules, Vol 24, Iss 21, p 3835 (2019)
Antigen-binding fragments of antibodies specific to the tumor-associated ganglioside GD2 are well poised to play a substantial role in modern GD2-targeted cancer therapies, however, rapid elimination from the body and reduced affinity compared to ful
Externí odkaz:
https://doaj.org/article/63d260e83a8b4c54842c491d2f1b4b63
Autor:
Irina V. Kholodenko, Leonid K. Kurbatov, Roman V. Kholodenko, Garik V. Manukyan, Konstantin N. Yarygin
Publikováno v:
Cells, Vol 8, Iss 10, p 1127 (2019)
Chronic liver diseases constitute a significant economic, social, and biomedical burden. Among commonly adopted approaches, only organ transplantation can radically help patients with end-stage liver pathologies. Cell therapy with hepatocytes as a tr
Externí odkaz:
https://doaj.org/article/b9697d24e24e4fd5aec9a2e22c70b9b2
Autor:
Daniel V. Kalinovsky, Irina V. Kholodenko, Alexey V. Kibardin, Igor I. Doronin, Elena V. Svirshchevskaya, Dmitriy Y. Ryazantsev, Maria V. Konovalova, Fedor N. Rozov, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1239
Ganglioside GD2 is a well-established target expressed on multiple solid tumors, many of which are characterized by low treatment efficiency. Antibody-drug conjugates (ADCs) have demonstrated marked success in a number of solid tumors, and GD2-direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e726fa50e723fc9f1d5c2294f92c7f5e
Autor:
Yan S. Kim, Daria M. Potashnikova, Alisa M. Gisina, Irina V. Kholodenko, Arthur T. Kopylov, Olga V. Tikhonova, Leonid K. Kurbatov, Aleena A. Saidova, Anna V. Tvorogova, Roman V. Kholodenko, Pavel V. Belousov, Ivan A. Vorobjev, Victor G. Zgoda, Konstantin N. Yarygin, Alexey Yu. Lupatov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9874
CD133 is an extensively studied marker of the most malignant tumor cell population, designated as cancer stem cells (CSCs). However, the function of this glycoprotein and its involvement in cell regulatory cascades are still poorly understood. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ca563c4ffe6204f45333d817d49d73