Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Irina V Ustyugova"'
Autor:
João Paulo Portela Catani, Anouk Smet, Tine Ysenbaert, Marnik Vuylsteke, Guy Bottu, Janick Mathys, Alexander Botzki, Guadalupe Cortes-Garcia, Tod Strugnell, Raul Gomila, John Hamberger, John Catalan, Irina V Ustyugova, Timothy Farrell, Svetlana Stegalkina, Satyajit Ray, Lauren LaRue, Xavier Saelens, Thorsten U Vogel
Publikováno v:
eLife, Vol 12 (2024)
Human H3N2 influenza viruses are subject to rapid antigenic evolution which translates into frequent updates of the composition of seasonal influenza vaccines. Despite these updates, the effectiveness of influenza vaccines against H3N2-associated dis
Externí odkaz:
https://doaj.org/article/bfab5878e3ed45778112b4cc2edd8358
Autor:
Irina V. Ustyugova, Svetlana Pougatcheva, Timothy Farrell, Tod Strugnell, Vardhini Ganesh, Konstantin B. Zeldovich, Sudha Chivukula, Ana P. Goncalvez, Mario Barro
Publikováno v:
Vaccine. 41:2022-2034
PDF file - 154K, Generation of Galphai2flx/flx-CD4-Cre mice and confirmation of Galphai2 deletion in T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274844b3f9edb339a38ce77da34df26d
https://doi.org/10.1158/1541-7786.22517113
https://doi.org/10.1158/1541-7786.22517113
Autor:
Daniel R. Boutz, Joshua M. DiNapoli, Jin Eyun Kim, Daechan Park, Svetlana Pougatcheva, Simon Delagrave, Irina V. Ustyugova, Congxi Ye, Jonathan R. McDaniel, George Georgiou, Ted M. Ross, Sophia Mundle, Gregory C. Ippolito, Bing Tan, Yuri Tanno, Jiwon Jung, Gregory R King, Jiwon Lee, Maria D. Person, Nicholas C. Curtis, Harry Kleanthous, Andrew P. Horton, Ponraj Prabakaran
Publikováno v:
J Clin Invest
Seasonal influenza vaccination elicits a diminished adaptive immune response in the elderly, and the mechanisms of immunosenescence are not fully understood. Using Ig-Seq, we found a marked increase with age in the prevalence of cross-reactive (CR) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1076ecfcf40e3eef63b99555024ebd5e
https://europepmc.org/articles/PMC8245176/
https://europepmc.org/articles/PMC8245176/
Autor:
Ted M. Ross, Thorsten U. Vogel, Irina V. Ustyugova, Anna Park, Simon Delagrave, Svetlana Stegalkina, Svetlana Pougatcheva, Ekaterina Boudanova, Jianxin Zhang, Yanfeng Zhou, Huawei Qiu, Ray Oomen, Sophia Mundle, Yu Qiu, Ponraj Prabakaran, Harry Kleanthous
Publikováno v:
J Virol
The discovery of potent and broadly protective influenza virus epitopes could lead to improved vaccines that are resistant to antigenic drift. Here, we describe human antibody C585, isolated from a vaccinee with remarkable serological breadth as meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d254fe6c26a5dce67865466863794f50
https://europepmc.org/articles/PMC7158729/
https://europepmc.org/articles/PMC7158729/
Autor:
Timothy Farrell, Irina V. Ustyugova, Konstantin V. Pugachev, Michael Vaine, Thorsten U. Vogel, Sanjay Phogat, Maryann Giel-Moloney, Svetlana Pougatcheva, Linong Zhang, Beata Gajewska, Xiaochu Duan, Mark Parrington, Harry Kleanthous
Publikováno v:
Human Vaccines & Immunotherapeutics
The RepliVax vaccine platform(RV) is based on flavivirus genomes that are rationally attenuated by deletion. The self-limiting infection provided by RV has been demonstrated to be safe, highly immunogenic and efficacious for several vaccine candidate
Publikováno v:
Expert Opinion on Therapeutic Targets. 17:593-606
The immediate early response gene X-1 (IEX-1) plays a pivotal role in the regulation of cell apoptosis, proliferation, differentiation and metabolism. Deregulation of IEX-1 expression has been confirmed in multiple cancers in humans, in association w
Publikováno v:
The Journal of Immunology. 189:1639-1647
CD4+ Th1 and Th17 cells both can cause autoimmune diseases, either alone or collaboratively, if left unchecked. However, what determines the dominant Th effector phenotype in a specific autoimmune disease remains poorly understood. Our present invest
Publikováno v:
Molecular Cancer Research. 10:760-767
The immediate early response gene X-1 (IEX-1) is involved in regulation of various cellular processes including proliferation, apoptosis in part by controlling homeostasis of reactive oxygen species (ROS) at mitochondria. The present study shows redu