Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Irina V Pinchuk"'
Autor:
Taslima T Lina, Shatha Alzahrani, Jennifer House, Yoshio Yamaoka, Arlene H Sharpe, Bill A Rampy, Irina V Pinchuk, Victor E Reyes
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121841 (2015)
During Helicobacter pylori (H. pylori) infection CD4+ T cells in the gastric lamina propria are hyporesponsive and polarized by Th1/Th17 cell responses controlled by Treg cells. We have previously shown that H. pylori upregulates B7-H1 expression on
Externí odkaz:
https://doaj.org/article/a598c471666d4b8697cfbf0b6d89ca0b
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98656 (2014)
Macrophage Migration Inhibitory Factor (MIF) is an inflammatory cytokine that is highly produced in gastrointestinal cancers. Since chronic inflammation is a risk factor for tumorigenesis in these cancers, in this study, the role of MIF in pro-tumori
Externí odkaz:
https://doaj.org/article/f3b767981b5c411fb04ed8e778fa5e34
Autor:
Irina V Pinchuk, Katherine T Morris, Robert A Nofchissey, Rachel B Earley, Jeng-Yih Wu, Thomas Y Ma, Ellen J Beswick
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53798 (2013)
Gastric cancer is associated with chronic inflammation and Helicobacter pylori infection. Th17 cells are CD4(+) T cells associated with infections and inflammation; but their role and mechanism of induction during carcinogenesis is not understood. Ga
Externí odkaz:
https://doaj.org/article/8fb7fe240d704afea896c6d11c0eba07
Autor:
Francisco Arroyo Almenas, Gábor Törő, Peter Szaniszlo, Manjit Maskey, Ketan K. Thanki, Walter A. Koltun, Gregory S. Yochum, Irina V. Pinchuk, Celia Chao, Mark R. Hellmich, Katalin Módis
Publikováno v:
Antioxidants, Vol 13, Iss 9, p 1067 (2024)
Cystathionine gamma-lyase (CSE) and TNF-α are now recognized as key regulators of intestinal homeostasis, inflammation, and wound healing. In colonic epithelial cells, both molecules have been shown to influence a variety of biological processes, bu
Externí odkaz:
https://doaj.org/article/7455c9bd5d034ec49d339a6ccd807eb1
Publikováno v:
Oncotarget. 14:377-381
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a788521bcec3e562bf51ed2cddf4f9f3
https://doi.org/10.18632/oncotarget.28399
https://doi.org/10.18632/oncotarget.28399
Autor:
Romain Villéger, Marina Chulkina, Randy C. Mifflin, Nikolay S. Markov, Judy Trieu, Mala Sinha, Paul Johnson, Jamal I. Saada, Patrick A. Adegboyega, Bruce A. Luxon, Ellen J. Beswick, Don W. Powell, Irina V. Pinchuk
Publikováno v:
British Journal of Cancer. 128:537-548
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f9988e6c95e7f2d46d531d854ddf6b4
https://doi.org/10.1038/s41416-022-02066-0
https://doi.org/10.1038/s41416-022-02066-0
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 259 (2021)
Colon adenocarcinoma is one of the most common malignancies, and it is highly lethal. Chemotherapy plays an important role in the treatment of colon cancer at various stages of the disease. The gut microbiome has emerged as a key player in colon canc
Externí odkaz:
https://doaj.org/article/73df50d9dd0d43c3b3f5e08ec822a276
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9165 (2020)
The gastrointestinal (GI) mucosa is among the most complex systems in the body. It has a diverse commensal microbiome challenged continuously by food and microbial components while delivering essential nutrients and defending against pathogens. For t
Externí odkaz:
https://doaj.org/article/441f132e428d4714b94a56c3218c45d2
Autor:
Brandon B. Phinney, Anita L. Ray, Amanda S. Peretti, Stephanie J. Jerman, Carl Grim, Irina V. Pinchuk, Ellen J. Beswick
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
A major risk factor for colon cancer growth and progression is chronic inflammation. We have shown that the MAPK-activated protein kinase 2 (MK2) pathway is critical for colon tumor growth in colitis-associated and spontaneous colon cancer models. Th
Externí odkaz:
https://doaj.org/article/3065e26185b54e1693af6022623fd207
Autor:
Yuriy Fofanov, Paul Johnson, Tammara L Watts, Don W. Powell, Walter A. Koltun, Gabriela Uribe, Kamil Khanipov, Carl Grim, Gregory S Yochum, Irina V. Pinchuk, Ellen J Beswick, Robert Noble
Publikováno v:
J Crohns Colitis
Background and AimsLittle is known about the presence and function of tissue-resident mesenchymal stem cells [MtSCs] within the gastrointestinal mucosa in health and inflammatory bowel disease [IBD]. The contribution of MtSCs to the generation of inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c87f141e1c80d3e2512c329c7e233c4
https://doi.org/10.1093/ecco-jcc/jjab001
https://doi.org/10.1093/ecco-jcc/jjab001