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Akademický článek

Proportion of the CD19-Positive and CD19-Negative Lymphocytes and Monocytes within the Peripheral Blood Mononuclear Cell Set Is Characteristic for Rheumatoid Arthritis

Autor: Irina Kholodnyuk, Anda Kadisa, Simons Svirskis, Sabine Gravelsina, Peteris Studers, Irina Spaka, Alina Sultanova, Sandra Lejniece, Aivars Lejnieks, Modra Murovska

Publikováno v: Medicina, Vol 55, Iss 10, p 630 (2019)

Background and objectives: Composition of the peripheral blood (PB) cell populations and their activation state reflect the immune status of a patient. Rheumatoid arthritis (RA) is characterized by abnormal B- and T-cell functions. The objective of t

Externí odkaz: https://doaj.org/article/a2fd575dd6294d1bbf16c2a21ff260a2

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Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia

Autor: Simons Svirskis, Ildze Ventina, Jelena Pavlova, Laura Hippe, Alla Rivkina, Sandra Lejniece, Irina Spaka, Irina Kholodnyuk, Svetlana Kozireva, Modra Murovska, Marina Soloveichika

Publikováno v: Journal of Clinical Medicine, Vol 9, Iss 2312, p 2312 (2020)
Journal of Clinical Medicine

Chemokines and their receptors direct migration and infiltration of immune cells. CCR1 and CCR2 maintain sequence similarity and respond to a number of the same chemokines secreted in lymphoid organs. Expression of CD38 on leukemic cells has been ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aa67f5743325f4673b1f0ca3433a82
https://www.mdpi.com/2077-0383/9/7/2312

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CXC chemokine ligand 4 (CXCL4) is predictor of tumour angiogenic activity and prognostic biomarker in non-small cell lung cancer (NSCLC) patients undergoing surgical treatment

Autor: Dainis Krievins, Darja Svirina, Inta Jaunalksne, Artjoms Spaks, Donats Breiva, Irina Spaka, Ilmars Tracums

Publikováno v: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 21(5)

Objective: To evaluate the association of CXC chemokine ligand 4 (CXCL4) plasma levels with tumour angiogenesis in non-small cell lung cancer (NSCLC) and to assess association of CXCL4 with clinical outcomes.Patients and methods: Fifty patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b055da9ef4dbe494bcb1c120af258637
https://pubmed.ncbi.nlm.nih.gov/27098116

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Diagnostic Value of Circulating CXC Chemokines in Non-small Cell Lung Cancer

Autor: Artjoms, Spaks, Inta, Jaunalksne, Irina, Spaka, Dimple, Chudasama, Ainis, Pirtnieks, Dainis, Krievins

Publikováno v: Anticancer research. 35(12)

To evaluate the diagnostic value of circulating CXC chemokines as biomarkers for non-small cell lung cancer and compare them against a standard panel of already existing cancer biomarkers.A total of 90 individuals were enrolled in the study. We analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d1c58dbd666646c3176daeb3910d6e4
https://pubmed.ncbi.nlm.nih.gov/26637925

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P2.01-040 CXC Chemokine Receptor 3 and ELR Motif Negative CXC Chemokine Ligand Axis in Non-Small Cell Lung Cancer

Autor: Donats Breiva, Artjoms Spaks, Anastasija Bistrova, Jurijs Nazarovs, Krista Grigorovica, Ilmars Tracums, Irina Spaka, Inta Jaunalksne

Publikováno v: Journal of Thoracic Oncology. 12:S809-S810

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::519467448792f403e935cd754a4d653b
https://doi.org/10.1016/j.jtho.2016.11.1092

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Dynamics of CXC group chemokine platelet factor 4 (PF4) plasma levels in non-small cell lung cancer (NSCLC)

Autor: Ainis Pirtnieks, Simona Donina, Jelena Grusina-Ujumaza, Artjoms Spaks, Inta Jaunalksne, Dainis Krievins, Irina Spaka, Aurika Babjoniseva

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 10, Iss Suppl 3, p P9 (2012)

CXC chemokines display pleiotropic effects participating not only in inflammation, but regulating angiogenesis and metastatic spread in cancer. Platelet factor 4 (PF4) is a 70-amino acid protein belonging to the CXC chemokine family. PF4 is also know

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f521b15781fb8465c464cf6c09e90f
https://doi.org/10.1186/1479-5876-10-s3-p9

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Flow cytometry immunophenotyping of peripheral blood circulating B-cell subset: comparison of osteoarthritis, chronic lymphocytic leukemia patients and normal donors

Autor: Irina Spaka, Artjoms Spaks, Alla Rivkina

Publikováno v: Journal of Translational Medicine, Vol 9, Iss Suppl 2, p P20 (2011)
Journal of Translational Medicine

Peripheral blood (PB) circulating B-cell subsets have been poorly defined until ≥6-color flow cytometry (FC) became available [1]. Traffic of the B-cell subsets between tissues through PB reflects the immune status of an individual subject and pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68d170bccf3042824a46283fae3d541
https://doaj.org/article/9f2d64858bc9496d97a21f02ac8cc203

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