Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Irina S. Zakharova"'
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Mhd Amin Arssan, Aleksei A. Sleptcov, Maria S. Nazarenko, Aleksei A. Zarubin, Nina V. Zheltysheva, Vlada A. Shevchenko, Narek A. Tmoyan, Shoraan B. Saaya, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 689 (2024)
Defects in the low-density lipoprotein receptor (LDLR) are associated with familial hypercholesterolemia (FH), manifested by atherosclerosis and cardiovascular disease. LDLR deficiency in hepatocytes leads to elevated blood cholesterol levels, which
Externí odkaz:
https://doaj.org/article/1a367c718be94a42babd8f91bc18a80c
Autor:
Maria S. Nazarenko, Aleksei A. Sleptcov, Aleksei A. Zarubin, Ramil R. Salakhov, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Nina V. Zheltysheva, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian, Irina S. Zakharova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4471 (2023)
The LDLR locus has clinical significance for lipid metabolism, Mendelian familial hypercholesterolemia (FH), and common lipid metabolism-related diseases (coronary artery disease and Alzheimer’s disease), but its intronic and structural variants ar
Externí odkaz:
https://doaj.org/article/76a44709a6c6408fb24208c4eaacb4dc
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102702- (2022)
The development of cellular models for familial hypercholesterolemia (FH) is an important direction for creating new approaches to atherosclerosis treatment. Pathogenic mutations in the LDLR gene are the main FH source. We generated an iPSC line from
Externí odkaz:
https://doaj.org/article/9ce40e3c957e4fa490098316d4c73f75
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Alexander P. Kalinin, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102703- (2022)
Familial hypercholesterolemia (FH) is an autosomal dominant disorder increasing premature cardiovascular diseases risk due to atherosclerosis. Pathogenic mutations in the LDLR gene cause most FH cases. Available treatments are effective not for all L
Externí odkaz:
https://doaj.org/article/e73fe039606f4f28b043708a40e0e084
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 59, Iss , Pp 102653- (2022)
Familial hypercholesterolemia (FH) is a monogenic disease, leading to atherosclerosis due to a high level of low-density lipoprotein cholesterol. Most cases of the disease are based on pathological variants in the LDLR gene. Hepatocyte-like and endot
Externí odkaz:
https://doaj.org/article/f5e3fb638e9f4e6db50a85dd319f5d83
Publikováno v:
Chromosome Research. 30:289-307
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 60, Iss, Pp 102702-(2022)
The development of cellular models for familial hypercholesterolemia (FH) is an important direction for creating new approaches to atherosclerosis treatment. Pathogenic mutations in the LDLR gene are the main FH source. We generated an iPSC line from
Publikováno v:
The International Journal of Developmental Biology. 63:223-233
In eutherian mammals, dosage compensation arose to balance X-linked gene expression between sexes and relatively to autosomal gene expression in the evolution of sex chromosomes. Dosage compensation occurs in early mammalian development and comprises
Autor:
Alexander I. Shevchenko, E.V. Dementyeva, Sergey P. Medvedev, A.A. Malakhova, E.V. Grigor'eva, Eugeny A. Elisaphenko, Irina S. Zakharova, S. V. Pavlova, Suren M. Zakian
Publikováno v:
Chromosoma. 127:129-139
In vole Microtus levis, cells of preimplantation embryo and extraembryonic tissues undergo imprinted X chromosome inactivation (iXCI) which is triggered by a long non-coding nuclear RNA, Xist. At early stages of iXCI, chromatin of vole inactive X chr
Autor:
Alexander I. Shevchenko, Y. A. Pokushalov, Andrey Karpenko, Ludmila N. Ivanova, Pavel P. Laktionov, A. V. Romashenko, Y. L. Zavyalov, Suren M. Zakian, Irina S. Zakharova, A. M. Volkov, A. M. Smirnova, M. K. Zhiven, Alena O. Stepanova, Sh. B. Saaya
Publikováno v:
Complex Issues of Cardiovascular Diseases. :47-63