Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Irina S. Moreira"'
Autor:
António J. Preto, Ana B. Caniceiro, Francisco Duarte, Hugo Fernandes, Lino Ferreira, Joana Mourão, Irina S. Moreira
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Cell-penetrating peptides (CPPs) are short chains of amino acids that have shown remarkable potential to cross the cell membrane and deliver coupled therapeutic cargoes into cells. Designing and testing different CPPs to target specific cell
Externí odkaz:
https://doaj.org/article/1d60b1471b364deaa8b2dd29a823412c
Autor:
Renato Socodato, Tiago O. Almeida, Camila C. Portugal, Evelyn C.S. Santos, Joana Tedim-Moreira, João Galvão-Ferreira, Teresa Canedo, Filipa I. Baptista, Ana Magalhães, António F. Ambrósio, Cord Brakebusch, Boris Rubinstein, Irina S. Moreira, Teresa Summavielle, Inês Mendes Pinto, João B. Relvas
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113447- (2023)
Summary: Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate th
Externí odkaz:
https://doaj.org/article/914f35ba494042d8aa265dd02cbdf0a4
Autor:
Beatriz Bueschbell, Pedro R. Magalhães, Carlos A.V. Barreto, Rita Melo, Anke C. Schiedel, Miguel Machuqueiro, Irina S. Moreira
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4336-4353 (2023)
G protein-coupled receptors (GPCRs) are known to dimerize, but the molecular and structural basis of GPCR dimers is not well understood. In this study, we developed a computational framework to generate models of symmetric and asymmetric GPCR dimers
Externí odkaz:
https://doaj.org/article/2c5100c6630647dcac9e0546876e59bc
Autor:
Ana B. Caniceiro, Beatriz Bueschbell, Carlos A.V. Barreto, António J. Preto, Irina S. Moreira
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 586-600 (2023)
G protein-coupled receptors (GPCRs) mediate several signaling pathways through a general mechanism that involves their activation, upholding a chain of events that lead to the release of molecules responsible for cytoplasmic action and further regula
Externí odkaz:
https://doaj.org/article/aeff22ed4fea4ad29625b37b5c201ab4
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract DrugTax is an easy-to-use Python package for small molecule detailed characterization. It extends a previously explored chemical taxonomy making it ready-to-use in any Artificial Intelligence approach. DrugTax leverages small molecule repres
Externí odkaz:
https://doaj.org/article/6ee7c1ca832c43218aa0fea037b6a5c3
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Blood cancers (BCs) are responsible for over 720 K yearly deaths worldwide. Their prevalence and mortality-rate uphold the relevance of research related to BCs. Despite the availability of different resources establishing Disease-
Externí odkaz:
https://doaj.org/article/f4bd4457bc00426bb737384175949fb5
Autor:
Irina S. Moreira
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8815 (2023)
This special edition intends to highlight how omics approaches have been used in biodegradation studies to understand the mechanisms involved and improve biodegradation processes [...]
Externí odkaz:
https://doaj.org/article/34caab205bb6479f8108c81c37136ec7
Autor:
Oumeima Boufercha, Ana R. Monforte, Allaoueddine Boudemagh, António C. Ferreira, Paula M. L. Castro, Irina S. Moreira
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14326 (2022)
Thiamethoxam (TMX) is an effective neonicotinoid insecticide. However, its widespread use is detrimental to non-targeted organisms and water systems. This study investigates the biodegradation of this insecticide by Labrys portucalensis F11. After 30
Externí odkaz:
https://doaj.org/article/519000ad623a4ba4ba4731604a6b75ff
Autor:
Carlos A. V. Barreto, Salete J. Baptista, António J. Preto, Daniel Silvério, Rita Melo, Irina S. Moreira
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
This paper describes an exciting big data analysis compiled in a freely available database, which can be applied to characterize the coupling of different G-Protein coupled receptors (GPCRs) families with their intracellular partners. Opioid receptor
Externí odkaz:
https://doaj.org/article/c80fb0d774114aedad8ef7a6cbb04402
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6181 (2022)
Endocrine disrupting compounds (EDCs) in the environment are considered a motif of concern, due to the widespread occurrence and potential adverse ecological and human health effects. The natural estrogen, 17β-estradiol (E2), is frequently detected
Externí odkaz:
https://doaj.org/article/06686099251747a18feb8c63f0894293