Mechanical stress driven by rigidity sensing governs epithelial stability

Autor: Surabhi Sonam, Lakshmi Balasubramaniam, Shao-Zhen Lin, Ying Ming Yow Ivan, Irina Pi-Jaumà, Cecile Jebane, Marc Karnat, Yusuke Toyama, Philippe Marcq, Jacques Prost, René-Marc Mège, Jean-François Rupprecht, Benoît Ladoux

Publikováno v: Nature Physics
Nature Physics, 2023, 19 (1), pp.132-141. ⟨10.1038/s41567-022-01826-2⟩

Epithelia act as a barrier against environmental stress and abrasion and in vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive. By culturing epit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d51a40c667c26208fbbe9535d5e1cea
https://doi.org/10.1038/s41567-022-01826-2

Collective durotaxis of cohesive cell clusters on a stiffness gradient

Autor: Irina Pi-Jaumà, Jaume Casademunt, Ricard Alert

Publikováno v: The European Physical Journal. E, Soft Matter
Dipòsit Digital de la UB
Universidad de Barcelona
European Physical Journal E

Many types of motile cells perform durotaxis, namely, directed migration following gradients of substrate stiffness. Recent experiments have revealed that cell monolayers can migrate toward stiffer regions even when individual cells do not -- a pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07197147c4695db076e0d9bdaae542d
https://pubmed.ncbi.nlm.nih.gov/35072824