Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Irina P. Krapf"'
Autor:
David J. King, Robert A. Horlick, Petra Verdino, Irina P. Krapf, Geoffery L. Tomlinson, John L. Macomber, Tamlyn Y. Neben, Peter Bowers, Jennifer L. Dalton
Publikováno v:
Journal of Biological Chemistry. 288:19861-19869
A mammalian expression system has been developed that permits simultaneous cell surface display and secretion of the same protein through alternate splicing of pre-mRNA. This enables a flexible system for in vitro protein evolution in mammalian cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c7e828a4e19ae445f758dcbe4232fb
https://doi.org/10.1074/jbc.m113.452482
https://doi.org/10.1074/jbc.m113.452482
Autor:
Ashley D. Berkebile, Audrey D. McConnell, Peter Bowers, Joseph C. Sheffer, John L. Macomber, David J. King, Steven S. Neben, Andy P. Chen, Robert A. Horlick, Irina P. Krapf, Vladimir Spasojevich
Publikováno v:
Protein Engineering Design and Selection. 26:151-164
Antibodies are important tools for a broad range of applications due to their high specificity and ability to recognize virtually any target molecule. However, in order to be practically useful, antibodies must be highly stable and bind their target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7315cc105800b3843017cde32deb94dc
https://doi.org/10.1093/protein/gzs090
https://doi.org/10.1093/protein/gzs090
Autor:
Laurence Altobell, Trevin Holland, Betty F. Wu, Geoffrey L. Tomlinson, Xue Zhang, Ashley D. Berkebile, Betty Chau, Rachelle M. Toobian, Robert A. Horlick, Steven S. Neben, John L. Macomber, David J. King, Jennifer L. Dalton, Tamlyn Y. Neben, Andy P. Chen, Irina P. Krapf, Heather A. Jones, Audrey D. McConnell, William J. Boyle, Peter Bowers
Publikováno v:
Proceedings of the National Academy of Sciences. 108:20455-20460
A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling in vitro somatic hypermutation (SHM) with mammalian cell display. SHM is dependent on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e75ec7744f8b52feb415f2e0ec09038
https://doi.org/10.1073/pnas.1114010108
https://doi.org/10.1073/pnas.1114010108
Autor:
Irina P. Krapf, Petra Verdino, Tamlyn Y. Neben, Betty F. Wu, Eric Hare, Audrey D. McConnell, Peter Bowers, Larry Altobell, Betty Chau, Robert A. Horlick, David J. King, John L. Macomber, Ashley D. Berkebile, Marilyn Kehry, Xue Zhang, Geoffery L. Tomlinson
Publikováno v:
Methods (San Diego, Calif.). 65(1)
Recent advances are described for the isolation and affinity maturation of antibodies that couple in vitro somatic hypermutation (SHM) with mammalian cell display, replicating key aspects of the adaptive immune system. SHM is dependent on the action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2908290eff61b3e24b23bbe39c5e177b
https://pubmed.ncbi.nlm.nih.gov/23792919
https://pubmed.ncbi.nlm.nih.gov/23792919