Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Irina O. Zakharova"'
1
Akademický článek
The Autophagic and Apoptotic Death of Forebrain Neurons of Rats with Global Brain Ischemia Is Diminished by the Intranasal Administration of Insulin: Possible Mechanism of Its Action
Autor: Irina O. Zakharova, Liubov V. Bayunova, Daria K. Avrova, Alina D. Tretyakova, Alexander O. Shpakov, Natalia F. Avrova
Publikováno v: Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6580-6599 (2024)
Insulin is a promising neuroprotector. To better understand the mechanism of insulin action, it was important to show its ability to diminish autophagic neuronal death in animals with brain ischemic and reperfusion injury. In forebrain ischemia and r
Externí odkaz: https://doaj.org/article/df0c4377e53c4b3f8c2302c2ae52c33a
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2
Akademický článek
Mitochondrial Electron Transport Chain in Heavy Metal-Induced Neurotoxicity: Effects of Cadmium, Mercury, and Copper
Autor: Elena A. Belyaeva, Tatyana V. Sokolova, Larisa V. Emelyanova, Irina O. Zakharova
Publikováno v: The Scientific World Journal, Vol 2012 (2012)
To clarify the role of mitochondrial electron transport chain (mtETC) in heavy-metal-induced neurotoxicity, we studied action of Cd2+, Hg2+, and Cu2+ on cell viability, intracellular reactive oxygen species formation, respiratory function, and mitoch
Externí odkaz: https://doaj.org/article/713d8c8a4d804e6ebb737c6281f39631
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4
Dual PTP1B/TC-PTP Inhibitors: Biological Evaluation of 3-(Hydroxymethyl)cinnoline-4(1H)-Ones
Autor: Kira V. Derkach, Maxim A. Gureev, Anastasia A. Babushkina, Vladimir N. Mikhaylov, Irina O. Zakharova, Andrey A. Bakhtyukov, Viktor N. Sorokoumov, Alexander S. Novikov, Mikhail Krasavin, Alexander O. Shpakov, Irina A. Balova
Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4498
Dual inhibitors of protein phosphotyrosine phosphatase 1B (PTP1B)/T-cell protein phosphotyrosine phosphatase (TC-PTP) based on the 3-(hydroxymethyl)-4-oxo-1,4-dihydrocinnoline scaffold have been identified. Their dual affinity to both enzymes has bee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ee525843fac4ff8f3e58edd1d1c585
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5
The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis
Autor: Andrey A. Bakhtyukov, Kira V. Derkach, Viktor N. Sorokoumov, Anna M. Stepochkina, Irina V. Romanova, Irina Yu. Morina, Irina O. Zakharova, Liubov V. Bayunova, Alexander O. Shpakov
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 198, p 198 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 198
In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin(hCG)-receptor (LH/hCG-R) (hCG, low-molecular-weight allosteric LH/hCG-R-agon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc592a1a044923259a7cf1c27b94abab
http://europepmc.org/articles/PMC8745465
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6
The estimation of the relative gene expression in the hypothalamus and liver of agouti mice using quantitative reverse transcription PCR v1
Autor: Kira V. Derkach, Irina O. Zakharova, Inna I. Zorina, Andrey Bakhtyukov, Irina V. Romanova, Liubov V. Bayunova, Alexander O. Shpakov
Female C57Bl/6J mice have a mutation in the Ay locus associated with overexpression of ASIP1, an antagonist of the types 3 and 4 melanocortin receptors. This mutation is characterized by the development of the melanocortin-type obesity. After treatme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14f604564b9724197a42d49aaafe8997
https://doi.org/10.17504/protocols.io.xrnfm5e
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8
Age-associated increase in salt sensitivity is accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump
Autor: Olga V. Fedorova, Vladimir A. Kashkin, Alexei Y. Bagrov, Irina O. Zakharova, Edward G. Lakatta
Publikováno v: Journal of Hypertension. 30:1817-1826
Marinobufagenin (MBG) promotes natriuresis via inhibition of renotubular Na/K-ATPase (NKA) and causes vasoconstriction via inhibition of vascular NKA. Atrial natriuretic peptide (ANP), via cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG)-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a83f70c50ab2f45d2e1a504a65233ad
https://doi.org/10.1097/hjh.0b013e328356399b
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9
Cocaine inhibits cromakalim-activated K + currents in follicle-enclosed Xenopus oocytes
Autor: Murat Oz, Irina O. Zakharova, Toni S. Shippenberg, Meral Dinc
Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 369:252-259
The effect of cocaine on K+ currents activated by the KATP channel opener cromakalim was investigated in follicular cells of Xenopus oocytes. The results indicate that cocaine in the concentration range of 3-500 microM reversibly inhibits cromakalim-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fada28aae35b8582ff6b7333bd7e8f1
https://doi.org/10.1007/s00210-003-0838-9
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10
Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity
Autor: Toni S. Shippenberg, Eileen M. Lafer, Bruce T. Hope, Irina O. Zakharova, Gerald A. Merrill, Jia Bei Wang, Jose A. Morón, Zhicheng Lin, Jonathan A. Javitch, Jasmine V. Ferrer, Aurelio Galli
Publikováno v: Scopus-Elsevier
ResearcherID
The dopamine transporter (DAT) regulates the clearance of dopamine (DA) released into the extracellular space and is an important site on which psychostimulants act to produce their effects. Here, we show that mitogen-activated protein kinase (MAPK)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2a220e38cb2621d1c38c334bbdcbcb
http://www.scopus.com/inward/record.url?eid=2-s2.0-0141569571&partnerID=MN8TOARS
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