Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Irina N. Gorshkova"'
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 2, Pp 100319- (2023)
Population studies have found that a natural human apoA-I variant, apoA-I[K107del], is strongly associated with low HDL-C but normal plasma apoA-I levels. We aimed to reveal properties of this variant that contribute to its unusual phenotype associat
Externí odkaz:
https://doaj.org/article/dd5955c0027e4b2ebafbc683d5807615
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 348-356 (2018)
ApoA-I activates LCAT that converts lipoprotein cholesterol to cholesteryl ester (CE). Molecular dynamic simulations suggested earlier that helices 5 of two antiparallel apoA-I molecules on discoidal HDL form an amphipathic tunnel for migration of ac
Externí odkaz:
https://doaj.org/article/4e0fb99ba2594a58afed1cfafcaacf8a
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1876-1885 (2014)
We found earlier that apoA-I variants that induced hypertriglyceridemia (HTG) in mice had increased affinity to TG-rich lipoproteins and thereby impaired their catabolism. Here, we tested whether a naturally occurring human apoA-I mutation, Lys107del
Externí odkaz:
https://doaj.org/article/d8f738c7be0245869500141007d285eb
Autor:
Andreas K. Kateifides, Irina N. Gorshkova, Adelina Duka, Angeliki Chroni, Dimitris Kardassis, Vassilis I. Zannis
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 7, Pp 1363-1372 (2011)
Abstract In this study, we investigated the role of positively and negatively charged amino acids within the 89-99 region of apolipoprotein A-I (apoA-I), which are highly conserved in mammals, on plasma lipid homeostasis and the biogenesis of HDL. We
Externí odkaz:
https://doaj.org/article/7ada80ffaa16446c960b9f97839a59e2
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 348-356 (2018)
ApoA-I activates LCAT that converts lipoprotein cholesterol to cholesteryl ester (CE). Molecular dynamic simulations suggested earlier that helices 5 of two antiparallel apoA-I molecules on discoidal HDL form an amphipathic tunnel for migration of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07af9e25f446fd525f264ac20522359
https://europepmc.org/articles/PMC5794428/
https://europepmc.org/articles/PMC5794428/
Autor:
Irina N, Gorshkova, David, Atkinson
Publikováno v:
JSM atherosclerosis. 2(2)
Hypertriglyceridemia (HTG) is an independent factor of atherosclerotic cardiovascular disease and a hallmark of many metabolic disorders. However, the molecular etiology of HTG is still largely unknown. In mice, severe HTG may be induced by expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e70d8e5a9536e8fc8a8935f9d9a00b2e
https://pubmed.ncbi.nlm.nih.gov/28597004
https://pubmed.ncbi.nlm.nih.gov/28597004
Autor:
Vassilis I. Zannis, Irina N. Gorshkova, Angeliki Chroni, Adelina Duka, Andreas K. Kateifides, Dimitris Kardassis
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 7, Pp 1363-1372 (2011)
In this study, we investigated the role of positively and negatively charged amino acids within the 89-99 region of apolipoprotein A-I (apoA-I), which are highly conserved in mammals, on plasma lipid homeostasis and the biogenesis of HDL. We previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de201a0e088b86ba8e7a2ebce9f12ac
https://doi.org/10.1194/jlr.m012989
https://doi.org/10.1194/jlr.m012989
Autor:
Horng-Yuan Kan, and Adelina Shkodrani, Vassilis I. Zannis, Kyriakos E. Kypreos, Irina N. Gorshkova, Angeliki Chroni
Publikováno v:
Biochemistry. 43:10442-10457
Hypertriglyceridemia is a common pathological condition in humans of mostly unknown etiology. Here we report induction of dyslipidemia characterized by severe hypertriglyceridemia as a result of point mutations in human apolipoprotein A-I (apoA-I). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb00b92ef754ce361edb18e4e58016f0
https://doi.org/10.1021/bi049782p
https://doi.org/10.1021/bi049782p
Autor:
Yoshinari Uehara, Vassilis I. Zannis, Angeliki Chroni, Arnold von Eckardstein, Horng-Yuan Kan, Tong Liu, Irina N. Gorshkova
Publikováno v:
Journal of Biological Chemistry. 278:6719-6730
We have mapped the domains of lipid-free apoA-I that promote cAMP-dependent and cAMP-independent cholesterol and phospholipid efflux. The cAMP-dependent lipid efflux in J774 mouse macrophages was decreased by ∼80–92% by apoA-I[Δ(185–243)], onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0392a1c890ce27d00f0b85d027210d03
https://doi.org/10.1074/jbc.m205232200
https://doi.org/10.1074/jbc.m205232200
Publikováno v:
Biochemistry. 41:10529-10539
To probe the structure and stability of the central region of lipid-free apolipoprotein (apo) A-I (residues 123-165), we studied the effects of four mutations made in this region on the conformation, stability, dimyristoylphosphatidylcholine (DMPC) b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da08b72b9ed9c182d3489fe7e155196a
https://doi.org/10.1021/bi025807d
https://doi.org/10.1021/bi025807d