Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Irina Mirkina"'
Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies
Autor:
Sara Sajko, Erin Skeens, Alexander Schinagl, Maroua Ferhat, Irina Mirkina, Julia Mayer, Gregor Rossmueller, Michael Thiele, George P. Lisi
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103264- (2024)
MIF is a ubiquitous protein involved in proinflammatory processes, which undergoes an oxidation-driven conformational change to oxidized (ox)MIF. We demonstrate that hypochlorous acid, produced by neutrophil-released myeloperoxidase (MPO) under infla
Externí odkaz:
https://doaj.org/article/c6babf44e7bb434a82ae91e78c563cd1
Autor:
Harald Rouha, Susanne Weber, Philipp Janesch, Barbara Maierhofer, Karin Gross, Ivana Dolezilkova, Irina Mirkina, Zehra C. Visram, Stefan Malafa, Lukas Stulik, Adriana Badarau, Eszter Nagy
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 231-247 (2018)
Pathogenesis of Staphylococcus aureus is increasingly recognized to be driven by powerful toxins. Staphylococcus aureus employs up to six pore-forming toxins to subvert the human host defense and to promote bacterial invasion: alpha-hemolysin that di
Externí odkaz:
https://doaj.org/article/bffc02e8566b438db1748413ad61e559
Autor:
Philipp Janesch, Harald Rouha, Adriana Badarau, Lukas Stulik, Irina Mirkina, Marisa Caccamo, Katharina Havlicek, Barbara Maierhofer, Susanne Weber, Karin Groß, Jacqueline Steinhäuser, Manuel Zerbs, Cecilia Varga, Ivana Dolezilkova, Sabine Maier, Gerhild Zauner, Nels Nielson, Christine A. Power, Eszter Nagy
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 1521-1538 (2018)
Streptococcus pneumoniae isolates express up to three neuraminidases (sialidases), NanA, NanB and NanC, all of which cleave the terminal sialic acid of glycan-structures that decorate host cell surfaces. Most research has focused on the role of NanA
Externí odkaz:
https://doaj.org/article/3d6e41b7d535455faecc94e43c18d40e
Autor:
Irina Mirkina, Emir Hadzijusufovic, Clemens Krepler, Mario Mikula, Diana Mechtcheriakova, Sabine Strommer, Alexander Stella, Erika Jensen-Jarolim, Christoph Höller, Volker Wacheck, Hubert Pehamberger, Peter Valent
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84417 (2014)
Malignant melanoma is a life-threatening skin cancer increasingly diagnosed in the western world. In advanced disease the prognosis is grave. Growth and metastasis formation in melanomas are regulated by a network of cytokines, cytokine-receptors, an
Externí odkaz:
https://doaj.org/article/cc58a81c66b84d88bfd1fe50d071f9fa
Autor:
Katharina Blatt, Harald Herrmann, Irina Mirkina, Emir Hadzijusufovic, Barbara Peter, Sabine Strommer, Gregor Hoermann, Matthias Mayerhofer, Konrad Hoetzenecker, Walter Klepetko, Viviane Ghanim, Katharina Marth, Thorsten Füreder, Volker Wacheck, Rudolf Valenta, Peter Valent
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29925 (2012)
The phosphoinositide 3-kinase (PI3-kinase) and the mammalian target of rapamycin (mTOR) are two major signaling molecules involved in growth and activation of mast cells (MC) and basophils (BA). We examined the effects of the dual PI3-kinase/mTOR blo
Externí odkaz:
https://doaj.org/article/c7d6adcdb2c34a199aa4c32fe5d38b44
Autor:
Barbara Peter, Karoline V. Gleixner, Sabine Cerny-Reiterer, Harald Herrmann, Viviane Winter, Emir Hadzijusufovic, Veronika Ferenc, Karina Schuch, Irina Mirkina, Hans-Peter Horny, Winfried F. Pickl, Leonhard Müllauer, Michael Willmann, Peter Valent
Publikováno v:
Haematologica, Vol 96, Iss 5 (2011)
Background In advanced systemic mastocytosis the response of neoplastic mast cells to conventional drugs is poor and the prognosis is bad. Current research is, therefore, attempting to identify novel drug targets in neoplastic mast cells. Polo-like k
Externí odkaz:
https://doaj.org/article/266949ddbdba4fd99fe7805468ab1d9b
Autor:
Gregor Rossmueller, Irina Mirkina, Barbara Maurer, Verena Hoeld, Julia Mayer, Michael Thiele, Randolf J. Kerschbaumer, Alexander Schinagl
Publikováno v:
Molecular Cancer Therapeutics. 22:555-569
High levels of macrophage migration inhibitory factor (MIF) in patients with cancer are associated with poor prognosis. Its redox-dependent conformational isoform, termed oxidized MIF (oxMIF), is a promising tumor target due to its selective occurren
Autor:
Alexander Schinagl, Randolf J. Kerschbaumer, Michael Thiele, Julia Mayer, Verena Hoeld, Barbara Maurer, Irina Mirkina, Gregor Rossmueller
Pharmacokinetics and BD of C0008, C0083, and C0090. A, BALB/c nude mice received a single intravenous injection of C0008, C0083, and C0090 mAbs (10 mg/kg), and plasma samples were collected 4, 10, 24, 48, and 96 hours thereafter. The plasma concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209cee8e4651945929eaa3ce43d5adbf
https://doi.org/10.1158/1535-7163.22758809
https://doi.org/10.1158/1535-7163.22758809
Autor:
Alexander Schinagl, Randolf J. Kerschbaumer, Michael Thiele, Julia Mayer, Verena Hoeld, Barbara Maurer, Irina Mirkina, Gregor Rossmueller
Physicochemical characterization of the mAb variants revealed identical binding properties and reduced hydrophobicity of the bioengineered anti-oxMIF antibodies compared with C0008 (imalumab). A, Antibody specificity of oxMIF versus redMIF in solutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c8bc223a50a5bf55f0b3a95751c24b
https://doi.org/10.1158/1535-7163.22758812.v1
https://doi.org/10.1158/1535-7163.22758812.v1
Autor:
Alexander Schinagl, Randolf J. Kerschbaumer, Michael Thiele, Julia Mayer, Verena Hoeld, Barbara Maurer, Irina Mirkina, Gregor Rossmueller
ON103 and ON203 mAbs with engineered Fc induce potent ADCC and ADCP. A, ON103 and ON203 trigger potent effector cell activation in ADCC reporter bioassays. Serial dilutions of mAbs were incubated for 6 hours with HCT116/pMIF target cells and Jurkat e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2169a0d0e556ed73571c2a632ec42f4e
https://doi.org/10.1158/1535-7163.22758806
https://doi.org/10.1158/1535-7163.22758806