Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues

Autor: Aude Thiriot, Carolina Perdomo, Guiying Cheng, Igor Novitzky-Basso, Sara McArdle, Jamie K. Kishimoto, Olga Barreiro, Irina Mazo, Robinson Triboulet, Klaus Ley, Antal Rot, Ulrich H. von Andrian

Publikováno v: BMC Biology, Vol 15, Iss 1, Pp 1-19 (2017)

Abstract Background Intravascular leukocyte recruitment in most vertebrate tissues is restricted to postcapillary and collecting venules, whereas capillaries and arterioles usually support little or no leukocyte adhesion. This segmental restriction i

Externí odkaz: https://doaj.org/article/050129e035084436bbac9a72b2b37b96

Antigen availability is a critical determinant of in vivo CD8+ T cell-dendritic cell interaction kinetics and initiates effector/memory fate decisions (110.21)

Autor: Sarah Henrickson, Balimkiz Senman, Michael Quigley, Gabriela Alexe, Susanne Stutte, Jonathan Jesneck, Matteo Iannacone, Michael Flynn, Sabrina Imam, Irina Mazo, William Haining, Ulrich von Andrian

Publikováno v: The Journal of Immunology. 188:110.21-110.21

Naïve CD8+ T cells are activated through interactions with antigen (Ag) bearing dendritic cells (DCs) in lymph nodes (LNs). Multiphoton intravital microscopy (MP-IVM) of LNs has demonstrated that T cell activation occurs in three phases. The durati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::207e4715da604b05361cc69b50b0adb0
https://doi.org/10.4049/jimmunol.188.supp.110.21

Translational Studies Using the MALT1 Inhibitor ( S )-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer.

Autor: Di Pilato M; MD Anderson Cancer Center, University of Texas, Houston, TX, USA., Gao Y; Monopteros Therapeutics, Boston, MA, USA., Sun Y; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Fu A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Grass C; Research Unit Signaling and Translation - Signaling and Immunity, Molecular Targets and Therapeutics Center, Helmholtz Munich-German Research Center for Environmental Health, Neuherberg, Germany., Seeholzer T; Research Unit Signaling and Translation - Signaling and Immunity, Molecular Targets and Therapeutics Center, Helmholtz Munich-German Research Center for Environmental Health, Neuherberg, Germany., Feederle R; Monoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Mazo I; Monopteros Therapeutics, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kazer SW; Monopteros Therapeutics, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Litchfield K; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., von Andrian UH; Harvard Medical School, Boston, MA, USA., Mempel TR; Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Jenkins RW; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Krappmann D; Research Unit Signaling and Translation - Signaling and Immunity, Molecular Targets and Therapeutics Center, Helmholtz Munich-German Research Center for Environmental Health, Neuherberg, Germany., Keller P; Monopteros Therapeutics, Boston, MA, USA.

Publikováno v: Journal of immunotherapy and precision oncology [J Immunother Precis Oncol] 2023 Mar 03; Vol. 6 (2), pp. 61-73. Date of Electronic Publication: 2023 Mar 03 (Print Publication: 2023).