Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Irina Maric"'
Autor:
Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W. Wright, James D. Phelan, Da Wei Huang, James W. Lord, Callie K. Van Winkle, Xin Yu, Jan Wisniewski, James Q. Wang, Frances A. Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A. Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J. Thomas, Ryan M. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
RAS mutations are commonly found in multiple myeloma (MM). Here, the authors show that oncogenic RAS mutations activate mTORC1 signalling in MM and combining mTORC1 and MEK/ERK inhibitors synergize to improve survival in preclinical models.
Externí odkaz:
https://doaj.org/article/8c3b0c0252af4d719539d036cf04abe8
Autor:
Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W. Wright, James D. Phelan, Da Wei Huang, James W. Lord, Callie K. Van Winkle, Xin Yu, Jan Wisniewski, James Q. Wang, Frances A. Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A. Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J. Thomas, Ryan M. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/b9cbaec1f91d41609ecd664007364658
Autor:
Emma M. Groarke, Bhavisha A. Patel, Alina Dulau‐Florea, Irina Maric, Neal S. Young, Katherine R. Calvo
Publikováno v:
eJHaem, Vol 1, Iss 2, Pp 404-405 (2020)
Externí odkaz:
https://doaj.org/article/b60687af58324f9798c89da98984a735
Autor:
Andrea Lisco, Chun-Shu Wong, Susan Price, Peiying Ye, Julie Niemela, Megan Anderson, Elizabeth Richards, Maura Manion, Harry Mystakelis, Morgan Similuk, Bernice Lo, Jennifer Stoddard, Sergio Rosenzweig, Christophe Vanpouille, Adam Rupert, Irina Maric, Ainhoa Perez-Diez, David Parenti, Peter D. Burbelo, V. Koneti Rao, Irini Sereti
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/0c02a451dd20455b95a189bfdc1f0bc9
Autor:
Andrea Lisco, Chun-Shu Wong, Susan Price, Peiying Ye, Julie Niemela, Megan Anderson, Elizabeth Richards, Maura Manion, Harry Mystakelis, Morgan Similuk, Bernice Lo, Jennifer Stoddard, Sergio Rosenzweig, Christophe Vanpouille, Adam Rupert, Irina Maric, Ainhoa Perez-Diez, David Parenti, Peter D. Burbelo, V. Koneti Rao, Irini Sereti
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoimmune lymphoproliferative syndrome (ALPS) is caused by germline or somatic loss of function FAS mutations resulting in impaired apoptosis and consequent expansion of T-lymphocytes causing organomegaly and autoimmune anemia, neutropenia and throm
Externí odkaz:
https://doaj.org/article/318ffdda9a354f6e903f114e3add0309
Autor:
Yi Xie, Stefania Pittaluga, Susan Price, Mark Raffeld, Jamie Hahn, Elaine S. Jaffe, V. Koneti Rao, Irina Maric
Publikováno v:
Haematologica, Vol 102, Iss 2 (2017)
Autoimmune lymphoproliferative syndrome is a rare genetic disorder characterized by defective FAS-mediated apoptosis, autoimmune disease, accumulation of mature T-cell receptor alpha/beta positive, CD4 and CD8 double-negative T cells and increased ri
Externí odkaz:
https://doaj.org/article/14d440eb36074573adea5faf016860f0
Autor:
Diego Acosta-Alvear, Min Y Cho, Thomas Wild, Tonia J Buchholz, Alana G Lerner, Olga Simakova, Jamie Hahn, Neha Korde, Ola Landgren, Irina Maric, Chunaram Choudhary, Peter Walter, Jonathan S Weissman, Martin Kampmann
Publikováno v:
eLife, Vol 4 (2015)
Hallmarks of cancer, including rapid growth and aneuploidy, can result in non-oncogene addiction to the proteostasis network that can be exploited clinically. The defining example is the exquisite sensitivity of multiple myeloma (MM) to 20S proteasom
Externí odkaz:
https://doaj.org/article/a66223f80c7441a6863650c2ab840d71
Autor:
Paneez Khoury, Jacqueline Herold, Alexandra Alpaugh, Ellen Dinerman, Nicole Holland-Thomas, Jennifer Stoddard, Shakuntala Gurprasad, Irina Maric, Olga Simakova, Lawrence B. Schwartz, Juelia Fong, Chyi-Chia Richard Lee, Liqiang Xi, Zengfeng Wang, Mark Raffeld, Amy D. Klion
Publikováno v:
Haematologica, Vol 100, Iss 3 (2015)
Episodic angioedema with eosinophilia (Gleich syndrome) is a rare disorder characterized by episodes of angioedema and eosinophilia that occur at monthly intervals and resolve spontaneously without therapy. Despite the striking periodicity of this di
Externí odkaz:
https://doaj.org/article/39a6b9fd3fa843079d0c7bbde67b2a19
Autor:
Neha Korde, Mattias Carlsten, Min-Jung Lee, Alex Minter, Esther Tan, Mary Kwok, Elisabet Manasanch, Manisha Bhutani, Nishant Tageja, Mark Roschewski, Adriana Zingone, Rene Costello, Marcia Mulquin, Diamond Zuchlinski, Irina Maric, Katherine R. Calvo, Raul Braylan, Prashant Tembhare, Constance Yuan, Maryalice Stetler-Stevenson, Jane Trepel, Richard Childs, Ola Landgren
Publikováno v:
Haematologica, Vol 99, Iss 6 (2014)
Externí odkaz:
https://doaj.org/article/3ff6b41d4efc4976a361e83d7ecd212d
Autor:
Weixin Wang, Meghan Corrigan-Cummins, Justin Hudson, Irina Maric, Olga Simakova, Sattva S. Neelapu, Larry W. Kwak, John E. Janik, Barry Gause, Elaine S. Jaffe, Katherine R. Calvo
Publikováno v:
Haematologica, Vol 97, Iss 4 (2012)
Background MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma.Design and Methods MicroRNA profiles of enriched follicular lymphoma tu
Externí odkaz:
https://doaj.org/article/9d56f0d8745d44dc992f50697bb5b6c1