Výsledky vyhledávání - "Irina Mantovani"

Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry

Autor: Irina Mantovani, Emanuela Ottaviani, Pier Luigi Tazzari, Giovanni Martinelli, Tiziana Grafone, Anna Maria Billi, Alberto M. Martelli, Roberto Conte, Alessandra Cappellini, Francesca Ricci

Publikováno v: British Journal of Haematology. 126:675-681

The phosphoinositide 3-kinase/Akt signalling pathway is a recently recognized important parameter in the prognosis and the response to treatment of acute myeloid leukaemia (AML). Akt kinase is activated by phosphorylation on Thr 308 and Ser 473. Acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc973a0071f0ccbb99fd42f3d064a8e7
https://doi.org/10.1111/j.1365-2141.2004.05121.x

Zobrazit plný text záznamu

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

Autor: Sara Mongiorgi, Irina Mantovani, Francesca Chiarini, Alessandra Cappellini, M Del Sole, Am Martelli, My Follo, Gc Gaboardi, J A McCubrey

Publikováno v: Leukemia. 22(6)

A significant impediment to the success of cancer chemotherapy is the occurrence of multidrug resistance, which, in many cases, is attributable to overexpression of membrane transport proteins, such as the 170-kDa P-glycoprotein (P-gp). Also, upregul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec8303c35e0c8016ed9701e072536f4
https://pubmed.ncbi.nlm.nih.gov/18385752

Zobrazit plný text záznamu

Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells

Autor: Alessandra Cappellini, Pier Luigi Tazzari, Alberto M. Martelli, Lucio Cocco, Veronica Papa, Irina Mantovani

Publikováno v: Journal of cellular physiology
207:3 (2006): 836–844.
info:cnr-pdr/source/autori:I. MANTOVANI, A. CAPPELLINI, P.L. TAZZARI, V. PAPA, L. COCCO, A.M. MARTELLI,/titolo:Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells,/doi:/rivista:Journal of cellular physiology (Print)/anno:2006/pagina_da:836/pagina_a:844/intervallo_pagine:836–844/volume:207:3

Multidrug resistance (MDR) mediated by the drug efflux protein, 170-kDa P-glycoprotein (P-gp), is one mechanism that tumor cells use to escape cell death induced by chemotherapeutic drugs. Moreover, evidence suggests that cell lines expressing high l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840cb59856a36a0780c1daf58de471b0
https://publications.cnr.it/doc/5202

Zobrazit plný text záznamu

Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

Autor: Alberto M. Martelli, Irina Mantovani, Maria Nyakern, Alessandra Cappellini

Publikováno v: Molecular cancer therapeutics 5:6 (2006): 1559–1570.
info:cnr-pdr/source/autori:M. NYAKERN, A. CAPPELLINI, I. MANTOVANI, A.M. MARTELLI,/titolo:Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways,/doi:/rivista:Molecular cancer therapeutics/anno:2006/pagina_da:1559/pagina_a:1570/intervallo_pagine:1559–1570/volume:5:6

Perifosine is an Akt inhibitor displaying strong antineoplastic effects in human tumor cell lines and is currently being tested in phase II clinical trials for treatment of major human cancers. Several recent studies showed the apoptotic effect of pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e771ee0d58daac44ef2c9ffe9a465f
http://hdl.handle.net/11580/9824

Zobrazit plný text záznamu

Application of flow cytometry to molecular medicine: Detection of tumor necrosis factor-related apoptosis-inducing ligand receptors in acute myeloid leukaemia blasts

Autor: Alberto M. Martelli, Giovanni Martinelli, Tiziana Grafone, Lucio Cocco, Irina Mantovani, Pier Luigi Tazzari, Alessandra Cappellini

Publikováno v: International Journal of Molecular Medicine 16 (2005): 1041–1048.
info:cnr-pdr/source/autori:A. CAPPELLINI, I. MANTOVANI, P.L. TAZZARI, T. GRAFONE, G. MARTINELLI, L. COCCO, A.M. MARTELLI,/titolo:Application of flow cytometry to molecular medicine: detection of tumor necrosis factor-related apoptosis-inducing ligand receptors in acute myeloid leukaemia blasts,/doi:/rivista:International Journal of Molecular Medicine/anno:2005/pagina_da:1041/pagina_a:1048/intervallo_pagine:1041–1048/volume:16

TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), a cytokine belonging to the TNF (tumor necrosis factor) family, is currently regarded as a potential anti-cancer agent. Nevertheless, several types of cancer cells display a low sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f09be9bd6b2dfd0ba2312890ba9afe
https://doi.org/10.3892/ijmm.16.6.1041

Zobrazit plný text záznamu

Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway

Autor: Pier Luigi Tazzari, Alessandra Cappellini, Roberta Bortul, Tiziana Grafone, Roberto Conte, Irina Mantovani, Giovanni Martinelli, Alberto M. Martelli, Giovanna Tabellini, Anna Maria Billi

Publikováno v: British journal of haematology
129 (2005): 677–686.
info:cnr-pdr/source/autori:R. BORTUL, P.L. TAZZARI, A.M. BILLI, G. TABELLINI, I. MANTOVANI, A. CAPPELLINI, T. GRAFONE, G. MARTINELLI, R. CONTE, A.M. MARTELLI,/titolo:Deguelin, A PI3K%2FAKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K%2FAKT pathway,/doi:/rivista:British journal of haematology (Print)/anno:2005/pagina_da:677/pagina_a:686/intervallo_pagine:677–686/volume:129

Activation of the phosphoinositide 3 kinase (PI3K)/Akt signalling pathway has been linked with resistance to chemotherapeutic drugs, and its downregulation, by means of PI3K inhibitors, lowers resistance to various types of therapy in tumour cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33141f8ddb531aa48f485d1ca4369ecc
http://hdl.handle.net/11580/10078

Zobrazit plný text záznamu

Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation

Autor: Anna Maria Billi, P. L. Tazzari, Irina Mantovani, Roberto Conte, Alessandra Cappellini, C. Tassi, Francesca Ricci, Alberto M. Martelli

Publikováno v: Apoptosis (Lond.) 10 (2005): 141–152.
info:cnr-pdr/source/autori:A. CAPPELLINI, P.L. TAZZARI, I. MANTOVANI, A.M. BILLI, C. TASSI, F. RICCI, R. CONTE, A.M. MARTELLI,/titolo:Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation,/doi:/rivista:Apoptosis (Lond.)/anno:2005/pagina_da:141/pagina_a:152/intervallo_pagine:141–152/volume:10

A combination of 8-methoxypsoralen and ultraviolet-A radiation (320-400 nm) (PUVA) is used for the treatment of T cell-mediated disorders, including chronic graft-versus-host disease, autoimmune disorders, and cutaneous T-cell lymphomas. The mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c94ae969074b525407268da2f951eed
http://www.cnr.it/prodotto/i/5240

Zobrazit plný text záznamu

A New Abl Kinase Inhibitor (AMN107) Has In Vitro Activity on Chronic Myeloid Leukaemia (CML) Ph+ Cells Resistant to Imatinib

Autor: Pier Luigi Tazzari, Marilina Amabile, Tiziana Grafone, Ilaria Iacobucci, Angela Poerio, Irina Mantovani, Alberto M. Martelli, Sabrina Colarossi, Simona Soverini, Giovanni Martinelli, Michele Baccarani, Carolina Terragna, Alessandra Cappellini, Matteo Renzulli, Emanuela Ottaviani

Publikováno v: Blood. 106:2004-2004

Imatinib mesylate (Novartis Pharma), an inhibitor of the bcr/abl tyrosine kinase, has rapidly become the first-line therapy for CML. Imatinib has proved remarkably effective at reducing the number of leukaemia cells in individual CML patients and pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3b853c46276d296fe7d2ff40172c1e8
https://doi.org/10.1182/blood.v106.11.2004.2004

Zobrazit plný text záznamu

A New Abl Kinase Inhibitor (AMN107) Has In Vitro Activity on CML Ph+Blast Cells Resistant to Imatinib

Autor: Marilina Amabile, Cristian Taccioli, Emanuela Ottaviani, Tiziana Grafone, Giovanni Martinelli, Carolina Terragna, Pier Luigi Tazzari, Michele Baccarani, Irina Mantovani, Matteo Renzulli, Alessandra Cappellini, Angela Poerio, Alberto M. Martelli, Gianantonio Rosti, Simona Soverini, Simona Bassi

Publikováno v: Blood. 104:4687-4687

Imatinib mesylate (STI571), an inhibitor of the bcr/abl tyrosine kinase, is rapidly becoming the first-line therapy for chronic myeloid leukemia (CML). Imatinib has proved remarkably effective at reducing the number of leukemia cells in individual CM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2d8e6931e9ae5135e65d5efa77b0d93
https://doi.org/10.1182/blood.v104.11.4687.4687

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání