Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Irina Luzina"'
Autor:
Violeta Rus, Alexandru Tatomir, Vinh Nguyen, Ana Talpos-Caia, John Papadimitriou, Sergei Atamas, Irina Luzina, Sun-Sang J Sung, Tudor Badea, Horea Rus
Publikováno v:
The Journal of Immunology. 202:132.3-132.3
Response Gene to Complement (RGC)-32 is a cell cycle regulator induced by complement activation, growth factors and cytokines. RGC-32 mediates TGF-β dependent profibrotic pathways, while in immune cells promotes the differentiation of Th17 cells in
Publikováno v:
The Journal of Immunology. 192:181.22-181.22
IL-33 levels and activity are differentially associated with Th1 and Th2 phenotypes. IL-33 mRNA is rapidly regulated but the fate of synthesized IL-33 protein is unknown. To assess the interplay between IL-33, IFN-γ, and IL-4 proteins, replication-d
Publikováno v:
The Journal of Immunology. 190:46.6-46.6
IL-33 precursor (IL33PR) released from damaged cells is known to bind to the receptor T1/ST2 and activate cells in culture. However, we found that in patients with interstitial lung diseases (ILD) and in the bleomycin mouse model of lung injury, pulm
Autor:
Sergei Atamas, Edward Pickering, Pavel Kopach, Phillip Kang, Virginia Lockatell, John Papadimitriou, Andrew McKenzie, Irina Luzina
Publikováno v:
The Journal of Immunology. 188:120.30-120.30
IL-33 is a key regulator of inflammation and immunity. It remains controversial whether protease-mediated activation of IL-33 is needed for functional effects. We constructed and validated recombinant adenoviruses for gene delivery of full-length mou
Publikováno v:
The Journal of Immunology. 188:56.11-56.11
IL-21 enhances CD8 maturation into cytotoxic T lymphocytes (CTL), promotes the differentiation of T follicular helper cells (TFH) cells and Th17 cells, downregulates Tregulatory (Treg) cells and exerts stimulatory activities on B cells, suggesting a
Autor:
Sergei Atamas, Irina Luzina
Publikováno v:
The Journal of Immunology. 188:44.3-44.3
CCL18 is an orphan chemokine present in primates but not in mice. Human CCL18 is fully functional in mice in vivo: it is chemotactic to mouse T lymphocytes similar to its effect on human T cells, suggesting that although mice have lost CCL18 after ev
Autor:
Pavel Kopach, Virginia Lockatell, Phillip Kang, Edward Pickering, Sergei Atamas, Irina Luzina
Publikováno v:
The Journal of Immunology. 188:120.8-120.8
Previous reports have been inconsistent on whether Interleukin (IL)-33 necessarily promotes Th2 effects in vivo. This diversity of findings may be due to post-synthetic processing of IL-33. We compared the in vivo effects of full-length mouse (flm) a
Publikováno v:
The Journal of Immunology. 186:117.15-117.15
Interleukin-4 is naturally produced in two splice isoforms, one encoded by exons 1-4 (IL-4), and the other encoded by exons 1, 3, and 4 (IL-4δ2). Our recent studies have suggested that both variants are biologically active in vivo, with partially ov
Autor:
Irina Luzina, Virginia Lockatell, Phillip Kang, Yulia Bashkatova, Sergey Andreev, Sergei Atamas
Publikováno v:
The Journal of Immunology. 186:117.14-117.14
A natural splice variant of IL-4 mRNA omits exon 2. It is unknown whether a corresponding protein, IL-4δ2, is also naturally produced. We have developed an mAb against IL-4δ2 with no cross-reactivity against IL-4. Freshly purified T cells from 8 pa
Publikováno v:
The Journal of Immunology. 186:166.23-166.23
Inflammation is often accompanied by fever, which may affect patients' survival in severe acute diseases. Pulmonary epithelium is involved in lung inflammation, and a major role for microRNAs has been suggested. To determine whether febrile temperatu