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pro vyhledávání: '"Irina Lojkin"'
Autor:
Beth Y. Karlan, Irina Lojkin, Omer Schwarzmann, Sandra Orsulic, Ido Wolf, Tami Rubinek, Shikha Bose
Publikováno v:
Cancer Letters. 362:149-157
Klotho is an anti-aging transmembrane protein, which can be shed and function as a hormone. Accumulating data indicate klotho as a tumor suppressor in a wide array of malignancies, and we identified klotho as an inhibitor of the insulin-like growth f
Autor:
Berta Cohen, Jehoshua Dor, Sarah Konopnicki, Rubens Fadini, Yuval Yung, Ariel Hourvitz, Mariabeatrice Dal Canto, Ettie Maman, Masha Brengauz, Irina Lojkin
Publikováno v:
Molecular and Cellular Endocrinology. 328:104-108
ADAM-metallopeptidase with thrombospondin type 1 motifs-1 (ADAMTS-1) null female mice show impaired follicular development and ovulatory processes. However, ADAMTS-1 expression and function in human normal ovulation and folliculogenesis have not yet
Publikováno v:
Cancer Research. 73:3557-3557
Klotho is a 1012 amino acid (aa) long transmembranal protein, which can be cleaved, shed and act as a circulating hormone. Klotho contains two regions named KL1 and KL2, each about 500aa long. Klotho deficient mice present a syndrome of early aging,