Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Irina L Tourkova"'
Autor:
Harry C Blair, Jonathan Soboloff, Irina L Tourkova, Jamie L. McCall, Suravi Ray, Margalit E Rosenkranz, Cristina Sobacchi, Lisa J Robinson, John B Barnett
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 248 (2024)
We review the abnormal bone turnover that is the basis of idiopathic inflammatory or rheumatoid arthritis and bone loss, with emphasis on Tumor Necrosis Factor-alpha (TNFα)-related mechanisms. We review selected data on idiopathic arthritis in juven
Externí odkaz:
https://doaj.org/article/8affe27a801d44a09bf66b64021e954b
Autor:
Lisa J Robinson, Jonathan Soboloff, Irina L Tourkova, Quitterie C Larrouture, Kelechi M Onwuka, Dionysios J Papachristou, Scott Gross, Robert Hooper, Elsie Samakai, Paul F Worley, Peng Liu, Jan Tuckermann, Michelle R Witt, Harry C Blair
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0264596 (2023)
The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline knock-out mice. To determine whether Orai1 has a direct, cell-intrinsic role in osteoblast
Externí odkaz:
https://doaj.org/article/0d49fd19421c433b8155853430aee8e7
Autor:
Steven F. Dobrowolski, Yu Leng Phua, Irina L. Tourkova, Cayla Sudano, Jerry Vockley, Quitterie C. Larrouture, Harry C. Blair
Publikováno v:
JIMD Reports, Vol 63, Iss 5, Pp 446-452 (2022)
Abstract Osteopenia is an under‐investigated clinical presentation of phenylalanine hydroxylase (PAH)‐deficient phenylketonuria (PKU). While osteopenia is not fully penetrant in human PKU, the Pahenu2 mouse is universally osteopenic and ideal to
Externí odkaz:
https://doaj.org/article/07e8c6faa3d54d05b9e4db6c6780f1ec
Autor:
Eleonora Palagano, Sharon Muggeo, Laura Crisafulli, Irina L. Tourkova, Dario Strina, Stefano Mantero, Elena Fontana, Silvia L. Locatelli, Marta Monari, Emanuela Morenghi, Carmelo Carlo-Stella, John B. Barnett, Harry C. Blair, Paolo Vezzoni, Anna Villa, Cristina Sobacchi, Francesca Ficara
Publikováno v:
Bone Reports, Vol 12, Iss , Pp 100242- (2020)
Background: Autosomal recessive osteopetrosis is a rare skeletal disorder with increased bone density due to a failure in osteoclast bone resorption. In most cases, the defect is cell-autonomous, and >50% of patients bear mutations in the TCIRG1 gene
Externí odkaz:
https://doaj.org/article/3f8fe2d8e8824e56b10a8f82d4302cc9
Autor:
Steven F. Dobrowolski, Yu Leng Phua, Irina L. Tourkova, Cayla Sudano, Jerry Vockley, Quitterie C. Larrouture, Harry C. Blair
Publikováno v:
JIMD Reports. 63:446-452
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::104f0c6bb07b31a3de95287958e940f1
https://doi.org/10.1002/jmd2.12308
https://doi.org/10.1002/jmd2.12308
Autor:
Irina L. Tourkova, Vladimir Riazanski, Kelechi M. Onwuka, Jonathan Franks, Steven F. Dobrowolski, Harry C. Blair, Quitterie C. Larrouture, Donna B. Stolz, Deborah J. Nelson, Paul H. Schlesinger
Publikováno v:
Biochem Biophys Res Commun
Osteoblasts in vivo form an epithelial-like layer with tight junctions between cells. Bone formation involves mineral transport into the matrix and acid transport to balance pH levels. To study the importance of the pH gradient in vitro, we used Tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6501762965767ba5379d3d4a27f7cc5
https://doi.org/10.1016/j.bbrc.2021.09.075
https://doi.org/10.1016/j.bbrc.2021.09.075
Autor:
Eric S. Goetzman, Irina L. Tourkova, Harry C. Blair, Steven F. Dobrowolski, Kayla Spridik, Jerry Vockley, Yu Leng Phua, Cayla Sudano
Publikováno v:
Molecular Genetics and Metabolism. 132:173-179
Osteopenia occurs in a subset of phenylalanine hydroxylase (PAH) deficient phenylketonuria (PKU) patients. While osteopenia is not fully penetrant in patients, the Pahenu2 classical PKU mouse is universally osteopenic, making it an ideal model of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f7efd0cafd691ce7d393027897f331e
https://doi.org/10.1016/j.ymgme.2021.01.014
https://doi.org/10.1016/j.ymgme.2021.01.014
Autor:
Harry C. Blair, Paul H. Schlesinger, Irina L. Tourkova, Donna B. Stolz, Evan C. Ray, Vladimir Riazanski, Deborah J. Nelson
Publikováno v:
Am J Physiol Cell Physiol
Bone differs from other connective tissues; it is isolated by a layer of osteoblasts that are connected by tight and gap junctions. This allows bone to create dense lamellar type I collagen, control pH, mineral deposition, and regulate water content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32ca7225f648559098218f08a2afd17
https://doi.org/10.1152/ajpcell.00120.2019
https://doi.org/10.1152/ajpcell.00120.2019
Autor:
Lisa J Robinson, Jonathan Soboloff, Irina L Tourkova, Quitterie C Larrouture, Dionysios J Papachristou, Scott Gross, Robert Hooper, Elsie Samakai, Paul F Worley, Jan Tuckermann, Michelle R Witt, Harry C Blair
The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline knock-out mice. To determine whether Orai1 has a direct, cell-intrinsic role in osteoblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39bee706de7a70770155306ea9b33bf4
https://doi.org/10.1101/2022.02.14.480443
https://doi.org/10.1101/2022.02.14.480443
Autor:
Ioanna Papadimitriou-Olivgeri, Steven F. Dobrowolski, Mone Zaidi, Harry C. Blair, Irina L. Tourkova, Cassandra Secunda, Dionysios J. Papachristou
Publikováno v:
Laboratory Investigation. 99:1850-1860
We examined bone formation and turnover in high-density lipoprotein (HDL) receptor, scavenger receptor type I (Scarb1), knockout animals relative to wild-type (WT) controls. Scarb1−/− animals have elevated serum adrenocorticotropic hormone (ACTH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e71fd17156d9b9444816e56be035808
https://doi.org/10.1038/s41374-019-0311-0
https://doi.org/10.1038/s41374-019-0311-0