Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Irina Kufareva"'
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Computational models of cell signaling networks are extremely useful tools for the exploration of underlying system behavior and prediction of response to various perturbations. By representing signaling cascades as executable Boo
Externí odkaz:
https://doaj.org/article/0db139fe0ff24c85bd66b8e9e043e574
Autor:
Tony Ngo, Bryan S Stephens, Martin Gustavsson, Lauren G Holden, Ruben Abagyan, Tracy M Handel, Irina Kufareva
Publikováno v:
PLoS Biology, Vol 18, Iss 4, p e3000656 (2020)
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets. Yet one of the
Externí odkaz:
https://doaj.org/article/d76fb27ba6414350aa8acc676fb407bc
Autor:
Jason Ear, Anokhi Saklecha, Navin Rajapakse, Julie Choi, Majid Ghassemian, Irina Kufareva, Pradipta Ghosh
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease. Polarization during planar cell migration is a special condition in which cellular
Externí odkaz:
https://doaj.org/article/9ec5144db75542578b74c2ea707f3a81
Autor:
Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens, Penglie Zhang, Thomas J. Schall, Sichun Yang, Ruben Abagyan, Mark R. Chance, Irina Kufareva, Tracy M. Handel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and
Externí odkaz:
https://doaj.org/article/dd25b21c34a34084a772b436c75162ce
Autor:
Kirti Kandhwal Chahal, Jie Li, Irina Kufareva, Milind Parle, Donald L Durden, Robert J Wechsler-Reya, Clark C Chen, Ruben Abagyan
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0214901 (2019)
Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB). However, SMO
Externí odkaz:
https://doaj.org/article/b9040d127fc44d0bab9439bf8e2656fe
Autor:
Neil J. Grimsey, Rachan Narala, Cara C. Rada, Sohum Mehta, Bryan S. Stephens, Irina Kufareva, John Lapek, David J. Gonzalez, Tracy M. Handel, Jin Zhang, JoAnn Trejo
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3312-3323.e5 (2018)
Summary: Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological processes. Ubiquitination of a subset of G-protein-coupled receptors (GPCRs) by the E3 ligase NEDD4-2 is required for p38 activation, but how
Externí odkaz:
https://doaj.org/article/82640e8206af4d0dadef32fb621a95fe
Publikováno v:
Membranes, Vol 5, Iss 4, Pp 646-663 (2015)
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology (PH) domain. As the first phosphoinositide binding module domain to be discovered, the PH domain recruits diverse protein architectures to cellular me
Externí odkaz:
https://doaj.org/article/1333d2cd87674bc9b42bc9a0d1edb69a
Autor:
Nicolas Aznar, Arjun Patel, Cristina C Rohena, Ying Dunkel, Linda P Joosen, Vanessa Taupin, Irina Kufareva, Marilyn G Farquhar, Pradipta Ghosh
Publikováno v:
eLife, Vol 5 (2016)
Loss of epithelial polarity impacts organ development and function; it is also oncogenic. AMPK, a key sensor of metabolic stress stabilizes cell-cell junctions and maintains epithelial polarity; its activation by Metformin protects the epithelial bar
Externí odkaz:
https://doaj.org/article/242bdc21d8c94924921c7a66668db1a9
Autor:
Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin, Michael R Dores, Thomas H Smith, Neil Grimsey, Ruben Abagyan, Joann Trejo, Irina Kufareva, Mark M Fuster, Catherina L Salanga, Tracy M Handel
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e81454 (2014)
Chemokines control cell migration in many contexts including development, homeostasis, immune surveillance and inflammation. They are also involved in a wide range of pathological conditions ranging from inflammatory diseases and cancer, to HIV. Chem
Externí odkaz:
https://doaj.org/article/a81e519e6a2349f3bedf602dc0a41d9d
Autor:
Samiksha Katiyar, Irina Kufareva, Ranjan Behera, Sarah M Thomas, Yuko Ogata, Michael Pollastri, Ruben Abagyan, Kojo Mensa-Wilmot
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56150 (2013)
Human African trypanosomiasis is caused by the eukaryotic microbe Trypanosoma brucei. To discover new drugs against the disease, one may use drugs in the clinic for other indications whose chemical scaffolds can be optimized via a medicinal chemistry
Externí odkaz:
https://doaj.org/article/e8481334dbb84912b0c2dc73fd99b985