Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Irina Klaman"'
Autor:
Cláudia S Ferreira, Konstanty Korski, Michael A Cannarile, Irina Klaman, Petra C Schwalie, Iakov I Davydov, Andreas Roller, Martha L Serrano-Serrano, Astrid Heller, Nicolas Staedler, Gabriele Dietmann, Alberto Valdeolivas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background The immune status of a patient’s tumor microenvironment (TME) may guide therapeutic interventions with cancer immunotherapy and help identify potential resistance mechanisms. Currently, patients’ immune status is mostly classified base
Externí odkaz:
https://doaj.org/article/a65b392cfd034dc18fbbd68b9a6b32bf
Autor:
Cláudia S. Ferreira, Galina Babitzki, Irina Klaman, Oliver Krieter, Katharina Lechner, Johanna Bendell, Suzana Vega Harring, Florian Heil
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionAngiopoetin-2 (Ang-2) is a key mediator of tumour angiogenesis. When upregulated it is associated with tumour progression and poor prognosis. Anti-vascular endothelial growth factor (VEGF) therapy has been widely used in the treatment of
Externí odkaz:
https://doaj.org/article/853678b68e134569808a0e71d37b5e1f
Autor:
Maurizio Ceppi, Bruno Gomes, Irina Klaman, Marta Canamero, Christian Heichinger, Tamara Tanos, Sabine Wilson, Mariana Bustamante, Chiahuey Ooi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/868e8b0a3c99497299b42e38438c364c
Publikováno v:
IET Image Processing, Vol 13, Iss 7, Pp 1066-1073 (2019)
A key challenge in cancer immunotherapy biomarker research is quantification of pattern changes in microscopic whole slide images of tumour biopsies. Drug development requires a correlative analysis of various biomarkers. To enable that, tissue slide
Externí odkaz:
https://doaj.org/article/beba4d942d6e4b749026ac72e3ffca69
Autor:
Jean-Marie Michot, Wolfgang Jacob, Francesca Michielin, Martin Weisser, Dmitriy Zamarin, Jean-Pascal Machiels, Anna-Maria Jegg, Dominik Rüttinger, Konstanty Korski, Jean-Pierre Delord, Carlos Gomez-Roca, Tara Mitchell, Gaetan Catala, Lauriane Eberst, Michael A Cannarile, Carl Watson, Galina Babitzki, Irina Klaman, Priscila Teixeira, Sabine Hoves, Carola Ries, Georgina Meneses-Lorente, Randolph Christen, Philippe Cassier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background This phase Ib study evaluated the safety, clinical activity, pharmacokinetics, and pharmacodynamics (PD) of emactuzumab (anti-colony stimulating factor 1 receptor monoclonal antibody (mAb)) in combination with selicrelumab (agonistic clust
Externí odkaz:
https://doaj.org/article/f591763d90694aa3ace112662e809f8f
Autor:
Radoslav Chekerov, Irina Klaman, Menelaos Zafrakas, Dominique Könsgen, Alexander Mustea, Beate Petschke, Werner Lichtenegger, Jalid Sehouli, Edgar Dahl
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 1, Pp 38-45 (2006)
OBJECTIVE: The aim of this study was to evaluate the expression of topoisomerase IIα (TOP2A) in epithelial and stromal cells of ovarian cancer. METHODS: TOP2A expression was analyzed in normal ovarian tissue and in laser-microdissected ovarian tumor
Externí odkaz:
https://doaj.org/article/df1ee54b69a242a5b884a9c165f01d2d
Autor:
Andreas Roller, Iakov Davydov, Martha Serrano-Serrano, Astrid Heller, Nicolas Staedler, Claudia Ferreira, Gabriele Dietmann, Irina Klaman, Konstanty Korski, Petra Schwalie, Michael Cannarile
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d99e81a165e330c8e2289fb575695562
https://doi.org/10.1136/jitc-2022-sitc2022.0027
https://doi.org/10.1136/jitc-2022-sitc2022.0027
Publikováno v:
IEEE Journal of Biomedical and Health Informatics. 25:403-411
Stain virtualization is an application with growing interest in digital pathology allowing simulation of stained tissue images thus saving lab and tissue resources. Thanks to the success of Generative Adversarial Networks (GANs) and the progress of u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4fffabbebc51e512df1548e39c17d
https://doi.org/10.1109/jbhi.2020.2975151
https://doi.org/10.1109/jbhi.2020.2975151
Autor:
Kristy L. Weber, Randolph Christen, Keelara Abiraj, Anna-Maria Jegg, Maud Toulmonde, Delphine Loirat, Martin Weisser, Irina Klaman, Michael A. Cannarile, Carlos Gomez-Roca, Jean-Yves Blay, Wolfgang Jacob, Antoine Italiano, Carl Watson, Francesca Michielin, Philippe A. Cassier, Jean-Pierre Delord, Dominik Rüttinger, Christophe Le Tourneau, Carola Ries, Sandra P. D'Angelo
Publikováno v:
European Journal of Cancer. 141:162-170
Objectives This study investigated the safety, clinical activity and patient-reported outcomes of patients with diffuse-type tenosynovial giant-cell tumour (dTGCT) of the soft tissue who were treated with emactuzumab, a humanised anti-colony stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c804865c629058c2f41dc964c91d3ce8
https://doi.org/10.1016/j.ejca.2020.09.038
https://doi.org/10.1016/j.ejca.2020.09.038
Autor:
Carlos Gomez-Roca, M. Campone, P. A. Cassier, Francesca Michielin, Wolfgang Jacob, Chia-Huey Ooi, Carl Watson, Michael A. Cannarile, J.-P. Delord, Antoine Italiano, Irina Klaman, Maud Toulmonde, Sandra P. D'Angelo, Bernhard Reis, Dominik Rüttinger, Randolph Christen, Georgina Meneses-Lorente, J.-Y. Blay, Delphine Loirat, K. Wonde, Kristy L. Weber, C. Le Tourneau, Anna-Maria Jegg, Carola Ries
Publikováno v:
Ann Oncol
Background Emactuzumab is a monoclonal antibody against the colony-stimulating factor-1 receptor and targets tumor-associated macrophages (TAMs). This study assessed the safety, clinical activity, pharmacokinetics (PK) and pharmacodynamics (PD) of em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4dddeb9ad3969192da6110fa8e7ad5
https://doi.org/10.1093/annonc/mdz163
https://doi.org/10.1093/annonc/mdz163