Výsledky vyhledávání - "Irina Kalashnikova"

Akademický článek

Prevalence of the cancer-associated germline variants in Russian adults and long-living individuals: using the ACMG recommendations and computational interpreters for pathogenicity assessment

Autor: Mariia Gusakova, Irina Dzhumaniiazova, Elena Zelenova, Daria Kashtanova, Mikhail Ivanov, Aleksandra Mamchur, Antonina Rumyantseva, Mikhail Terekhov, Sergey Mitrofanov, Liliya Golubnikova, Aleksandra Akinshina, Konstantin Grammatikati, Irina Kalashnikova, Vladimir Yudin, Valentin Makarov, Anton Keskinov, Sergey Yudin

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundPopulation studies are essential for gathering critical disease prevalence data. Automated pathogenicity assessment tools enhance the capacity to interpret and annotate large amounts of genetic data. In this study, we assessed the prevalenc

Externí odkaz: https://doaj.org/article/0a05383c55ae4bb28d54115409e25fc5

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Therapeutic Potential of Combinative shRNA-Encoded Lentivirus-Mediated Gene Silencing to Accelerate Somatosensory Recovery After Spinal Cord Trauma

Autor: Jonghyuck Park, Matthew Farmer, Camara Casson, Irina Kalashnikova, Daniel Kolpek

Publikováno v: Neurotherapeutics. 20:564-577

Neuropathic pain following spinal cord injury (SCI) remains a difficult problem that affects more than 80% of SCI patients. Growing evidence indicates that neuroinflammatory responses play a key role in neuropathic pain after SCI. Short hairpin RNA (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f044090ed8ea8de9477fb11f373cff
https://doi.org/10.1007/s13311-022-01331-7

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Encapsulation of Oil Phases with Different Compositions into a Shell Composed of Nanoparticles of Natural Hydrothermal Silica and Polyelectrolyte Layers

Autor: V. N. Zelenkov, K. V. Palamarchuk, Irina Kalashnikova, Tatiana Bukreeva, V. V. Potapov

Publikováno v: Colloid Journal. 83:228-235

Particles of natural hydrothermal nanosilica have been characterized, and the conditions of their self-organization have been chosen for the stabilization of oil-in-water emulsions with the use of a cationic surfactant. Microcapsules, which consist o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aee20828578d69e8a997047876b99dfd
https://doi.org/10.1134/s1061933x21020083

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Abstract LB001: Encapsulation of IL-12 with an ultra pH-sensitive nanoparticle platform improves tolerability and promotes antitumor response in mice

Autor: Qingtai Su, Stephen Gutowski, Irina Kalashnikova, Austin Burcham, Bhargavi Allu, Zirong Chen, Zhichen Sun, Jinming Gao, Ruolan Han, Jason B. Miller, Tian Zhao

Publikováno v: Cancer Research. 83:LB001-LB001

Background: Interleukin-12 is a potent proinflammatory cytokine that proliferates and activates T cells, NK cells and differentiates Th1 cells. Translation of IL-12 for cancer treatment has been hindered by lethal toxicities due to cytokine release s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0133602c427950da624a9ab3a0c68b79
https://doi.org/10.1158/1538-7445.am2023-lb001

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Abstract 815: Improved tolerability and tumor specific delivery of a therapeutic bispecific T cell engager using a pH-sensitive nanoparticle platform

Autor: Qingtai Su, Stephen Gutowski, Gaurav Bharadwaj, Austin Burcham, Bhargavi Allu, Irina Kalashnikova, Zirong Chen, Ruolan Han, Jason B. Miller, Tian Zhao

Publikováno v: Cancer Research. 83:815-815

Bispecific antibodies are an emerging class of therapeutics for immune-oncology applications. T cell engagers (TCEs) target tumor-associated antigens (TAA) to eradicate cancer cells. TCEs for solid tumors have demonstrated encouraging preclinical eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f069fa33cc270c60b2fd94c5c8a646e
https://doi.org/10.1158/1538-7445.am2023-815

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Macrophage-targeted single walled carbon nanotubes stimulate phagocytosis via pH-dependent drug release

Autor: Mozhgan Lotfi, Niloufar Hosseini-Nassab, Jianqin Ye, Bryan Ronain Smith, Yapei Zhang, Irina Kalashnikova, Nicholas J. Leeper, Alyssa M. Flores, Sesha L. A. Paluri

Publikováno v: Nano Research. 14:762-769

Atherosclerotic cardiovascular disease is the leading cause of mortality in the world. A driving feature of atherosclerotic plaque formation is dysfunctional efferocytosis. Because the “don’t eat me” molecule CD47 is upregulated in atherosclero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd7a301f10ac8c62c0f72ceb0eb02b4a
https://doi.org/10.1007/s12274-020-3111-3

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Functional response of Betula species to edaphic and nutrient stress during restoration of fly ash deposits in the Middle Urals (Russia)

Autor: Larissa Ivanova, Anna Ivanova, Dina Ronzhina, Svetlana Migalina, Irina Kalashnikova, Leonid Ivanov

Publikováno v: Environmental Science and Pollution Research. 28:12714-12724

We studied the impact of fly ash produced by the thermal power station in the Middle Urals (Russia) on functional traits of two Betula species naturally colonizing ash dump lagoons. The main limiting factors for tree growth on fly ash deposits were n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54eb5bb786df773cb24083022942d246
https://doi.org/10.1007/s11356-020-11200-5

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