Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Irina Hutson"'
Publikováno v:
Dev Biol
To investigate the role of adipose tissue in reproductive function and mammary gland development and function, we have examined lipodystrophic (LD) mice. LD mice of both sexes are sterile, but fertility can be restored with leptin injections. Mammary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cc57da881666198ab1958df09bbe2b
https://doi.org/10.1016/j.ydbio.2019.11.001
https://doi.org/10.1016/j.ydbio.2019.11.001
Publikováno v:
Journal of the Endocrine Society
To investigate the role of adipose tissue in the function of the mammary gland (MG) and reproductive system, we have examined lipodystrophic (LD) mice. LD mice of both sexes are sterile, but fertility was restored in both sexes with leptin injections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f1e267f15af2b2e1a36f32ef5dbe8d
https://doi.org/10.1210/jendso/bvaa046.134
https://doi.org/10.1210/jendso/bvaa046.134
Autor:
Antonina Akk, John P. Atkinson, Charles A. Harris, Dennis E. Hourcade, Xiaobo Wu, Irina Hutson, Rebecca J. Brown, Smita Mascharak, Christine T. N. Pham
Publikováno v:
The Journal of Immunology. 200:2786-2797
Factor D (FD) is an essential component of the complement alternative pathway (AP). It is an attractive pharmaceutical target because it is an AP-specific protease circulating in blood. Most components of the complement activation pathways are produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ce284947d5a519b052e6ce9dc67c07
https://doi.org/10.4049/jimmunol.1701668
https://doi.org/10.4049/jimmunol.1701668
Autor:
Ruhang Tang, Daniel Ferguson, Christine T.N. Pham, Charles A. Harris, Steven L. Teitelbaum, Gretchen A. Meyer, Arin K. Oestreich, Kristin L. Lenz, Yun-Rak Choi, Kelsey H. Collins, Irina Hutson, E.N. Pollitt, Farshid Guilak, Luke E. Springer
Publikováno v:
Osteoarthritis and Cartilage. 29:S14-S15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c1bd8401e1e0d21f234f8f5f81a58e3
https://doi.org/10.1016/j.joca.2021.02.034
https://doi.org/10.1016/j.joca.2021.02.034
Autor:
Kevin Thomas Bauerle, Irina Hutson, Eric Tycksen, Daniel Ferguson, Charles A. Harris, Terri A. Pietka
Publikováno v:
Endocrinology
Increased visceral adiposity and hyperglycemia, 2 characteristics of metabolic syndrome, are also present in conditions of excess glucocorticoids (GCs). GCs are hormones thought to act primarily via the glucocorticoid receptor (GR). GCs are commonly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580ba36afc6b874791e70ee2b225afae
https://pubmed.ncbi.nlm.nih.gov/32036385
https://pubmed.ncbi.nlm.nih.gov/32036385
Publikováno v:
Journal of the Endocrine Society
Rates of obesity and metabolic syndrome (MetS) are at epidemic levels, leading to a rise of individuals at higher risk of developing diabetes and heart disease. Increased visceral adiposity and hyperglycemia are two shared features of MetS and excess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a330b3ef582b6c777d32a963501315f2
https://doi.org/10.1210/js.2019-or28-1
https://doi.org/10.1210/js.2019-or28-1
Autor:
Christine T.N. Pham, Farshid Guilak, Charles A. Harris, Kristin L. Lenz, Yun-Rak Choi, Gretchen A. Meyer, Ruhang Tang, Arin K. Oestreich, Steven L. Teitelbaum, Eleanor N. Pollitt, Irina Hutson, Luke E. Springer, Daniel Ferguson, Kelsey H. Collins
Publikováno v:
Proc Natl Acad Sci U S A
Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally affects individuals with obesity. The mechanisms by which obesity leads to the onset and progression of OA are unclear due to the complex interactions among th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b10dcc8300341e60d347204c920213c
https://doi.org/10.1038/s41584-021-00579-1
https://doi.org/10.1038/s41584-021-00579-1
Publikováno v:
Endocrinology. 157:4943-4960
Exogenous glucocorticoid administration results in hyperglycemia, insulin resistance, hepatic dyslipidemia, and hypertension, a constellation of findings known as Cushing’s syndrome. These effects are mediated by the glucocorticoid receptor (GR). B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79800c98156a2dbc46abe6f58ccd0cc4
https://doi.org/10.1210/en.2016-1615
https://doi.org/10.1210/en.2016-1615
Publikováno v:
Endocrinology. 159(9)
The global obesity epidemic is fueling alarming rates of diabetes, associated with increased risk of cardiovascular disease and cancer. Leptin is a hormone secreted by adipose tissue that is a key regulator of body weight (BW) and energy expenditure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47248299776fac6c0f133d81d24d5732
https://pubmed.ncbi.nlm.nih.gov/30085057
https://pubmed.ncbi.nlm.nih.gov/30085057
Publikováno v:
Endocrinology. 159(5)
Regulation of adipogenesis is of major interest given that adipose tissue expansion and dysfunction are central to metabolic syndrome. Glucocorticoids (GCs) are important for adipogenesis in vitro. However, establishing a role for GCs in adipogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e02a020832c4ba6586036259060f5a2
https://pubmed.ncbi.nlm.nih.gov/29579167
https://pubmed.ncbi.nlm.nih.gov/29579167