Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Irina Heid"'
Autor:
Irina Heid, Corinna Münch, Sinan Karakaya, Smiths S. Lueong, Alina M. Winkelkotte, Sven T. Liffers, Laura Godfrey, Phyllis F. Y. Cheung, Konstantinos Savvatakis, Geoffrey J. Topping, Florian Englert, Lukas Kritzner, Martin Grashei, Andrea Tannapfel, Richard Viebahn, Heiner Wolters, Waldemar Uhl, Deepak Vangala, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Daniel Rauh, Wilko Weichert, Jörg D. Hoheisel, Stephan A. Hahn, Franz Schilling, Rickmer Braren, Marija Trajkovic-Arsic, Jens T. Siveke
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) lacks effective treatment options beyond chemotherapy. Although molecular subtypes such as classical and QM (quasi-mesenchymal)/basal-like with transcriptome-based distinct signatures have b
Externí odkaz:
https://doaj.org/article/bde08f1443834615a3f9cb25e23e0e2b
Autor:
Simone Ballke, Irina Heid, Carolin Mogler, Rickmer Braren, Markus Schwaiger, Wilko Weichert, Katja Steiger
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is an urgent need to improve histop
Externí odkaz:
https://doaj.org/article/76bc99a4499f4e348ef2355c2d4dd0e4
Autor:
Elisabeth Bliemsrieder, Georgios Kaissis, Martin Grashei, Geoffrey Topping, Jennifer Altomonte, Christian Hundshammer, Fabian Lohöfer, Irina Heid, Dominik Keim, Selamawit Gebrekidan, Marija Trajkovic-Arsic, Aline Winkelkotte, Katja Steiger, Roman Nawroth, Jens Siveke, Markus Schwaiger, Marcus Makowski, Franz Schilling, Rickmer Braren
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The in vivo assessment of tissue metabolism represents a novel strategy for the evaluation of oncologic disease. Hepatocellular carcinoma (HCC) is a high-prevalence, high-mortality tumor entity often discovered at a late stage. Recent eviden
Externí odkaz:
https://doaj.org/article/e0a491a41dc04952be5b8e9b40040ec7
Autor:
Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S. P. Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T. Stathopoulos, Jürgen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias Heikenwalder, Charles Swanton, Nicholas McGranahan, Philipp J. Jost
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Cancer cells frequently harbour genetic aberrations that protect them from programmed cell death. Here, the authors show in non-small cell lung cancer that the anti-apoptotic gene MCL-1 is subject to copy number gains and that deletion of MCL-1 reduc
Externí odkaz:
https://doaj.org/article/e72e961b8ad54302879663e878f7c62b
Autor:
Elisabeth Bliemsrieder, Georgios Kaissis, Martin Grashei, Geoffrey Topping, Jennifer Altomonte, Christian Hundshammer, Fabian Lohöfer, Irina Heid, Dominik Keim, Selamawit Gebrekidan, Marija Trajkovic-Arsic, AM Winkelkotte, Katja Steiger, Roman Nawroth, Jens Siveke, Markus Schwaiger, Marcus Makowski, Franz Schilling, Rickmer Braren
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ef4a7a702fa94f6ebd05fc4931519cda
Autor:
Clara Lubeseder-Martellato, Katharina Alexandrow, Ana Hidalgo-Sastre, Irina Heid, Sophie Luise Boos, Thomas Briel, Roland M. Schmid, Jens T. Siveke
Publikováno v:
EBioMedicine, Vol 15, Iss C, Pp 90-99 (2017)
Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRasG12D, which induces neoplastic transformation of acinar cells throu
Externí odkaz:
https://doaj.org/article/ff6254514d0345c18bbe53ca00bc6f3c
Autor:
Geoffrey J. Topping, Irina Heid, Marija Trajkovic-Arsic, Lukas Kritzner, Martin Grashei, Christian Hundshammer, Maximilian Aigner, Jason G. Skinner, Rickmer Braren, Franz Schilling
Publikováno v:
Biomedicines, Vol 9, Iss 2, p 121 (2021)
Hyperpolarized 13C nuclear magnetic resonance spectroscopy can characterize in vivo tissue metabolism, including preclinical models of cancer and inflammatory disease. Broad bandwidth radiofrequency excitation is often paired with free induction deca
Externí odkaz:
https://doaj.org/article/e87b3e143df74a7d8c3003f4665b8ebf
Autor:
Roman Maresch, Sebastian Mueller, Christian Veltkamp, Rupert Öllinger, Mathias Friedrich, Irina Heid, Katja Steiger, Julia Weber, Thomas Engleitner, Maxim Barenboim, Sabine Klein, Sandra Louzada, Ruby Banerjee, Alexander Strong, Teresa Stauber, Nina Gross, Ulf Geumann, Sebastian Lange, Marc Ringelhan, Ignacio Varela, Kristian Unger, Fengtang Yang, Roland M. Schmid, George S. Vassiliou, Rickmer Braren, Günter Schneider, Mathias Heikenwalder, Allan Bradley, Dieter Saur, Roland Rad
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
CRISPR/Cas9 technology has been used for genome engineering in vivo. Here, the authors use a transfection technique to deliver multiple guide RNAs to the pancreas of adult mice, allowing genetic screening and chromosome engineering in pancreatic canc
Externí odkaz:
https://doaj.org/article/8d54419326794a6ba55ff4332e373a04
Autor:
Irina, Heid, Marija, Trajkovic-Arsic, Fabian, Lohöfer, Georgios, Kaissis, Felix N, Harder, Moritz, Mayer, Geoffrey J, Topping, Friderike, Jungmann, Barbara, Crone, Moritz, Wildgruber, Uwe, Karst, Lucia, Liotta, Hana, Algül, Hsi-Yu, Yen, Katja, Steiger, Wilko, Weichert, Jens T, Siveke, Marcus R, Makowski, Rickmer F, Braren
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 50:115-129
Purpose Pancreatic ductal adenocarcinoma (PDAC) is a molecularly heterogeneous tumor entity with no clinically established imaging biomarkers. We hypothesize that tumor morphology and physiology, including vascularity and perfusion, show variations t
Autor:
Jason G. Skinner, Geoffrey J. Topping, Luca Nagel, Irina Heid, Christian Hundshammer, Martin Grashei, Frits H. A. van Heijster, Rickmer Braren, Franz Schilling
Publikováno v:
Magnetic Resonance in Medicine.