Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Irina Grabovec"'
Autor:
Anastasiya Tumilovich, Evgeniy Yablokov, Yuri Mezentsev, Pavel Ershov, Viktoriia Basina, Oksana Gnedenko, Leonid Kaluzhskiy, Tatsiana Tsybruk, Irina Grabovec, Maryia Kisel, Polina Shabunya, Natalia Soloveva, Nikita Vavilov, Andrei Gilep, Alexis Ivanov
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2072 (2024)
Dehydroepiandrosterone (DHEA), a precursor of steroid sex hormones, is synthesized by steroid 17-alpha-hydroxylase/17,20-lyase (CYP17A1) with the participation of microsomal cytochrome b5 (CYB5A) and cytochrome P450 reductase (CPR), followed by sulfa
Externí odkaz:
https://doaj.org/article/d17b52e100b34eb98ae64a4985b5e9f4
Autor:
Andrei Gilep, Tatsiana Varaksa, Sergey Bukhdruker, Anton Kavaleuski, Yury Ryzhykau, Sviatlana Smolskaya, Tatsiana Sushko, Kouhei Tsumoto, Irina Grabovec, Ivan Kapranov, Ivan Okhrimenko, Egor Marin, Mikhail Shevtsov, Alexey Mishin, Kirill Kovalev, Alexander Kuklin, Valentin Gordeliy, Leonid Kaluzhskiy, Oksana Gnedenko, Evgeniy Yablokov, Alexis Ivanov, Valentin Borshchevskiy, Natallia Strushkevich
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Ferredoxins are small iron–sulfur proteins and key players in essential metabolic pathways. Among all types, 3Fe–4S ferredoxins are less studied mostly due to anaerobic requirements. Their complexes with cytochrome P450 redox partners have not be
Externí odkaz:
https://doaj.org/article/6cc0066959ee4a48a08a2713d9d6501e
Autor:
Leonid Kaluzhskiy, Pavel Ershov, Evgeniy Yablokov, Tatsiana Shkel, Irina Grabovec, Yuri Mezentsev, Oksana Gnedenko, Sergey Usanov, Polina Shabunya, Sviatlana Fatykhava, Alexander Popov, Aleksandr Artyukov, Olga Styshova, Andrei Gilep, Natallia Strushkevich, Alexis Ivanov
Publikováno v:
Molecules, Vol 26, Iss 8, p 2237 (2021)
Widespread pathologies such as atherosclerosis, metabolic syndrome and cancer are associated with dysregulation of sterol biosynthesis and metabolism. Cholesterol modulates the signaling pathways of neoplastic transformation and tumor progression. La
Externí odkaz:
https://doaj.org/article/8f5b809dbd474750a69dc887199d5c98
Autor:
Sergey Bukhdruker, Tatsiana Varaksa, Irina Grabovec, Egor Marin, Polina Shabunya, Maria Kadukova, Sergei Grudinin, Anton Kavaleuski, Anastasiia Gusach, Andrei Gilep, Valentin Borshchevskiy, Natallia Strushkevich
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7683 (2020)
Spreading of the multidrug-resistant (MDR) strains of the one of the most harmful pathogen Mycobacterium tuberculosis (Mtb) generates the need for new effective drugs. SQ109 showed activity against resistant Mtb and already advanced to Phase II/III c
Externí odkaz:
https://doaj.org/article/9fced5ea79184d17bb63e5ddd4b8d716
Autor:
Wolfram Tempel, Irina Grabovec, Farrell MacKenzie, Yaroslav V. Dichenko, Sergey A. Usanov, Andrei A. Gilep, Hee-Won Park, Natallia Strushkevich
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1925-1932 (2014)
Hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7α-hydroxycholesterol. To identify the structura
Externí odkaz:
https://doaj.org/article/d9f4e2677f5a4e7b996e9e894a97ed20
Autor:
Sergey Bukhdruker, Tatsiana Varaksa, Philipp Orekhov, Irina Grabovec, Egor Marin, Ivan Kapranov, Kirill Kovalev, Roman Astashkin, Leonid Kaluzhskiy, Alexis Ivanov, Alexey Mishin, Andrey Rogachev, Valentin Gordeliy, Andrei Gilep, Natallia Strushkevich, Valentin Borshchevskiy
Publikováno v:
Acta Crystallographica Section D Structural Biology. 79:66-77
New antitubercular drugs are vital due to the spread of resistant strains. Carbethoxyhexyl imidazole (CHImi) inhibits cytochrome P450 CYP124, which is a steroid-metabolizing enzyme that is important for the survival of Mycobacterium tuberculosis in m
Autor:
Andrei Gilep, Tatsiana Varaksa, Sergey Bukhdruker, Anton Kavaleuski, Yury Ryzhykau, Sviatlana Smolskaya, Tatsiana Sushko, Kouhei Tsumoto, Irina Grabovec, Ivan Kapranov, Ivan Okhrimenko, Egor Marin, Mikhail Shevtsov, Alexey Mishin, Kirill Kovalev, Alexander Kuklin, Valentin Gordeliy, Leonid Kaluzhskiy, Oksana Gnedenko, Evgeniy Yablokov, Alexis Ivanov, Valentin Borshchevskiy, Natallia Strushkevich
Ferredoxins are small iron-sulfur proteins and key players in essential metabolic pathways. Among all types, 3Fe-4S ferredoxins are less studied mostly due to anaerobic requirements. Their complexes withcytochromeP450 redox partners have not been str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19cd8a2e8a35a1be0058e6e74a723061
https://doi.org/10.1101/2022.11.02.514812
https://doi.org/10.1101/2022.11.02.514812
Autor:
Andrey Gilep, Irina Grabovec, Vladimir I. Dolgopalets, Tatsiana Varaksa, T. V. Shkel, Yu. G. Charnou, Natalya V. Strushkevich
Publikováno v:
Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 54:450-454
The interaction of human monooxygenases and pathogenic fungi with previously obtained esters of isomeric 7-methyl-19-nor-testosterones and a number of heteroaromatic acids – derivatives of pyridine and pyrazine, was studied. Interaction with the ac
Autor:
Alexander S. Apt, R. Astashkin, Konstantin B. Majorov, Vladimir I. Dolgopalets, Aleksandra Luginina, Ivan Maslov, Natallia Strushkevich, Sviatlana Smolskaya, Valentin Gordeliy, Raisa P. Litvinovskaya, Boris Nikonenko, Andrei A. Gilep, Darrell E. Hurt, Anna Kavaleuskaya, Anton Kavaleuski, Polina Shabunya, Tatsiana Varaksa, A. V. Rogachev, Egor Marin, Alex Rosenthal, Yury Charnou, Mikhail B. Shevtsov, Anastasiia Gusach, Valentin Borshchevskiy, Evgeny Shevchenko, Alaksiej L. Hurski, Kirill Kovalev, Sergey Bukhdruker, Dmitrii Zabelskii, Alexander V. Baranovsky, Aleh Savachka, Alexey Mishin, Andrei Gabrielian, Irina Grabovec
Publikováno v:
Journal of molecular biology 433(4), 166763-(2021). doi:10.1016/j.jmb.2020.166763
Mycobacterium tuberculosis (Mtb) infection is among top ten causes of death worldwide, and the number of drug-resistant strains is increasing. The direct interception of human immune signaling molecules by Mtb remains elusive, limiting drug discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5941fde8889634dd0a0610b952e0f6
https://hdl.handle.net/2128/29692
https://hdl.handle.net/2128/29692
Autor:
Anna Kavaleuskaya, Rami A. Masamrekh, Larisa V. Sigolaeva, Victoria V. Shumyantseva, T. A. Sushko, Anton Kavaleuski, Andrei A. Gilep, Sergei Bukhdruker, Kouhei Tsumoto, Natallia Strushkevich, Egor Marin, Daniil Vakhrameev, Valentin Borshchevskiy, Alexey V. Kuzikov, Irina Grabovec
Electron transfer mediated by metalloproteins drives many biological processes. Rubredoxins are ubiquitous iron-containing electron carriers that play important roles in bacterial adaptation to changing environmental conditions. In Mycobacterium tube
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c95a2a27e56594c8d42e064d8d4ac6f
https://doi.org/10.1101/2020.10.27.356691
https://doi.org/10.1101/2020.10.27.356691