Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Irina Gorshkova"'
Autor:
Nigel J. Pyne, Susan Pyne, David G. Watson, Robert Bittman, Evgeny Berdyshev, Irina Gorshkova, Francesca Tonelli, Viswanathan Natarajan, Manal Alossaimi
Publikováno v:
Biomolecules, Vol 3, Iss 2, Pp 316-333 (2013)
We have previously shown that treatment of androgen-sensitive LNCaP cells with the sphingosine kinase (SK) inhibitor SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of two N-terminal variants of SK1 (SK1a and
Externí odkaz:
https://doaj.org/article/a246bb63785c461c9259b124ddc26ac9
Autor:
Irina Gorshkova, Tong Zhou, Biji Mathew, Jeffrey R. Jacobson, Daisuke Takekoshi, Palash Bhattacharya, Brett Smith, Bulent Aydogan, Ralph R. Weichselbaum, Viswanathan Natarajan, Joe G.N. Garcia, Evgeny V. Berdyshev
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 8, Pp 1553-1568 (2012)
The enforcement of sphingosine-1-phosphate (S1P) signaling network protects from radiation-induced pneumonitis. We now demonstrate that, in contrast to early postirradiation period, late postirradiation sphingosine kinase-1 (SphK1) and sphingoid base
Externí odkaz:
https://doaj.org/article/51f1dd75cab0445c9c1f5a09c28aed9c
Autor:
Evgeny V Berdyshev, Irina Gorshkova, Peter Usatyuk, Satish Kalari, Yutong Zhao, Nigel J Pyne, Susan Pyne, Roger A Sabbadini, Joe G N Garcia, Viswanathan Natarajan
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16571 (2011)
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cell
Externí odkaz:
https://doaj.org/article/cc99e3f2d99b49cfbd0f1ee6c9092044
Autor:
Irina Gorshkova, Olga Miryasova
Publikováno v:
Woman in Russian Society. :29-44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9f82dcf8487765e1bc73d3f7b1be396
https://doi.org/10.21064/winrs.2020.1.3
https://doi.org/10.21064/winrs.2020.1.3
Autor:
Dale A. Pelligrino, John Kilkus, Vidyani Suryadevara, Hao Liang Xu, Glyn Dawson, Fernando D. Testai, Evgeny V. Berdyshev, Irina Gorshkova
Publikováno v:
Journal of Neuroscience Research. 93:796-805
We previously described how ceramide (Cer), a mediator of cell death, increases in the cerebrospinal fluid (CSF) of subarachnoid hemorrhage (SAH) patients. This study investigates the alterations of biochemical pathways involved in Cer homeostasis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5aa833574aafa689dfa0cbe2c3e6f80
https://doi.org/10.1002/jnr.23542
https://doi.org/10.1002/jnr.23542
Autor:
Gye Young Park, Jian Du, Glenn D. Prestwich, Panfeng Fu, Sangwoon Chung, Ravi Ranjan, Eleanna Kaffe, Ioanna Ninou, Andrew J. Morris, Elizabeth A. B. Kelly, Steven J. Ackerman, Lei Xiao, Sharmilee M. Nyenhuis, Susan J. Corbridge, Nizar N. Jarjour, John W. Christman, Irina Gorshkova, Viswanathan Natarajan, Vassilis Aidinis, Jerold Chun, Jing Deng, Evgeny V. Berdyshev, Manjula Karpurapu, Yong Gyu Lee, Susan S. Smyth, H. Ari Jaffe, Yongchao Li
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 188:928-940
Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95470fb6cc4cf078c110a6ecda89b19d
https://doi.org/10.1164/rccm.201306-1014oc
https://doi.org/10.1164/rccm.201306-1014oc
Autor:
Steve Garzon, Peter V. Usatyuk, Evgeny V. Berdyshev, Narsa M. Reddy, J. Usha Raj, Anantha Harijith, Vijay Mohan, Tao Bai, Prasad Kanteti, Irina Gorshkova, Viswanathan Natarajan, Long Shuang Huang, Sekhar P. Reddy, Srikanth Pendyala
Publikováno v:
The American Journal of Pathology. 183(4):1169-1182
Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury, resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal mice to hyperoxia enhanced sphingosine-1-phosphate (S1P) levels in lung tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9f2f52add76a9746b34c6cc174d26d
Autor:
Robert Bittman, Francesca Tonelli, Evgeny V. Berdyshev, Irina Gorshkova, Manal Alossaimi, Nigel J. Pyne, Viswanathan Natarajan, David G. Watson, Susan Pyne
Publikováno v:
Biomolecules
Biomolecules, Vol 3, Iss 2, Pp 316-333 (2013)
Volume 3
Issue 2
Pages 316-333
Biomolecules, Vol 3, Iss 2, Pp 316-333 (2013)
Volume 3
Issue 2
Pages 316-333
We have previously shown that treatment of androgen-sensitive LNCaP cells with the sphingosine kinase (SK) inhibitor SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of two N-terminal variants of SK1 (SK1a and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6df41fc54fe47c0dfd2f183a1ef63bf
https://doi.org/10.3390/biom3020316
https://doi.org/10.3390/biom3020316
Autor:
Evgeny V. Berdyshev, Bernard Portha, Hervé Le Stunff, Julien Véret, E. Riccitelli, Magali Fradet, Paola Giussani, Nadim Kassis, Jonathan Goya, Viswanathan Natarajan, Irina Gorshkova, Nicolas Coant, Anastasia Skobeleva
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1831:251-262
Sphingoid base-1-phosphates represent a very low portion of the sphingolipid pool but are potent bioactive lipids in mammals. This study was undertaken to determine whether these lipids are produced in palmitate-treated pancreatic β cells and what r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85d24d7d04c125194c4b56c2ddfef1c
https://doi.org/10.1016/j.bbalip.2012.10.003
https://doi.org/10.1016/j.bbalip.2012.10.003
Autor:
Brett Smith, Bulent Aydogan, Jeffrey R. Jacobson, Tong Zhou, Biji Mathew, Ralph R. Weichselbaum, Evgeny Berdyshev, Palash Bhattacharya, Viswanathan Natarajan, Joe G.N. Garcia, Irina Gorshkova, Daisuke Takekoshi
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 8, Pp 1553-1568 (2012)
The enforcement of sphingosine-1-phosphate (S1P) signaling network protects from radiation-induced pneumonitis. We now demonstrate that, in contrast to early postirradiation period, late postirradiation sphingosine kinase-1 (SphK1) and sphingoid base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c621d22d4d7b2e1285daaea76456bc
http://www.sciencedirect.com/science/article/pii/S0022227520418590
http://www.sciencedirect.com/science/article/pii/S0022227520418590