Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Irina Gladkikh"'
Autor:
Oksana Sintsova, Darya Popkova, Aleksandr Kalinovskii, Anton Rasin, Natalya Borozdina, Elvira Shaykhutdinova, Anna Klimovich, Alexander Menshov, Natalia Kim, Stanislav Anastyuk, Mikhail Kusaykin, Igor Dyachenko, Irina Gladkikh, Elena Leychenko
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115743- (2023)
Diabetes mellitus is a serious threat to human health in both developed and developing countries. Optimal disease control requires the use of a diet and a combination of several medications, including oral hypoglycemic agents such as α-glucosidase i
Externí odkaz:
https://doaj.org/article/297f320926754531b825e09b094c4006
Autor:
Daria Popkova, Nadezhda Otstavnykh, Oksana Sintsova, Sergey Baldaev, Rimma Kalina, Irina Gladkikh, Marina Isaeva, Elena Leychenko
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2682 (2023)
Diabetes mellitus is one of the most serious diseases of our century. The drugs used are limited or have serious side effects. The search for new sources of compounds for effective treatment is relevant. Magnificamide, a peptide inhibitor of mammalia
Externí odkaz:
https://doaj.org/article/c08bd79ea261445b8cf2681916c1d8f2
Autor:
Ernesto Lopes Pinheiro-Junior, Rimma Kalina, Irina Gladkikh, Elena Leychenko, Jan Tytgat, Steve Peigneur
Publikováno v:
Marine Drugs, Vol 20, Iss 2, p 147 (2022)
Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area. As part of its venom components, the Hcr 1
Externí odkaz:
https://doaj.org/article/007b6581581f41c4b6636dbc7d86e033
Autor:
Dongchen An, Ernesto Lopes Pinheiro-Junior, László Béress, Irina Gladkikh, Elena Leychenko, Eivind A. B. Undheim, Steve Peigneur, Jan Tytgat
Publikováno v:
Marine Drugs, Vol 20, Iss 2, p 140 (2022)
(1) Background: G protein-coupled inward-rectifier potassium (GIRK) channels, especially neuronal GIRK1/2 channels, have been the focus of intense research interest for developing drugs against brain diseases. In this context, venom peptides that sel
Externí odkaz:
https://doaj.org/article/c30e3f24ff8f44c7821bc2c20af3c4bc
Autor:
Aleksandra Kvetkina, Elena Kostina, Irina Gladkikh, Victoria Chausova, Ekaterina Yurchenko, Irina Bakunina, Mikhail Pivkin, Stanislav Anastyuk, Roman Popov, Margarita Monastyrnaya, Emma Kozlovskaya, Marina Isaeva, Pavel Dmitrenok, Elena Leychenko
Publikováno v:
Marine Drugs, Vol 19, Iss 12, p 654 (2021)
The peculiarities of the survival and adaptation of deep-sea organisms raise interest in the study of their metabolites as promising drugs. In this work, the hemolytic, cytotoxic, antimicrobial, and enzyme-inhibitory activities of tentacle extracts f
Externí odkaz:
https://doaj.org/article/363eff82e3554b57b67882f7ad2f3472
Autor:
Oksana Sintsova, Irina Gladkikh, Anna Klimovich, Yulia Palikova, Viktor Palikov, Olga Styshova, Margarita Monastyrnaya, Igor Dyachenko, Sergey Kozlov, Elena Leychenko
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 716 (2021)
Currently the TRPV1 (transient receptor potential vanilloid type 1) channel is considered to be one of the main targets for pro-inflammatory mediators including TNF-α. Similarly, the inhibition of TRPV1 activity in the peripheral nervous system affe
Externí odkaz:
https://doaj.org/article/730f420cbea54d599b0359b09e8e4ce6
Autor:
Oksana Sintsova, Irina Gladkikh, Margarita Monastyrnaya, Valentin Tabakmakher, Ekaterina Yurchenko, Ekaterina Menchinskaya, Evgeny Pislyagin, Yaroslav Andreev, Sergey Kozlov, Steve Peigneur, Jan Tytgat, Dmitry Aminin, Emma Kozlovskaya, Elena Leychenko
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 283 (2021)
Kunitz-type peptides from venomous animals have been known to inhibit different proteinases and also to modulate ion channels and receptors, demonstrating analgesic, anti-inflammatory, anti-histamine and many other biological activities. At present,
Externí odkaz:
https://doaj.org/article/1e1b34edb4d842bf990c4fef7e0d9233
Autor:
Irina Gladkikh, Steve Peigneur, Oksana Sintsova, Ernesto Lopes Pinheiro-Junior, Anna Klimovich, Alexander Menshov, Anatoly Kalinovsky, Marina Isaeva, Margarita Monastyrnaya, Emma Kozlovskaya, Jan Tytgat, Elena Leychenko
Publikováno v:
Biomedicines, Vol 8, Iss 11, p 473 (2020)
The Kunitz/BPTI peptide family includes unique representatives demonstrating various biological activities. Electrophysiological screening of peptides HCRG1 and HCRG2 from the sea anemone Heteractis crispa on six Kv1.x channel isoforms and insect Sha
Externí odkaz:
https://doaj.org/article/5459fee03f8a4f228f7f7edb12628d46
Autor:
Irina Gladkikh, Margarita Monastyrnaya, Elena Zelepuga, Oksana Sintsova, Valentin Tabakmakher, Oksana Gnedenko, Alexis Ivanov, Kuo-Feng Hua, Emma Kozlovskaya
Publikováno v:
Marine Drugs, Vol 13, Iss 10, Pp 6038-6063 (2015)
Sea anemones are a rich source of Kunitz-type polypeptides that possess not only protease inhibitor activity, but also Kv channels toxicity, analgesic, antihistamine, and anti-inflammatory activities. Two Kunitz-type inhibitors belonging to a new Het
Externí odkaz:
https://doaj.org/article/fcb6c6c1946d4fb4a4c4709bd47ab617
Autor:
Oksana Sintsova, Irina Gladkikh, Aleksandr Kalinovskii, Elena Zelepuga, Margarita Monastyrnaya, Natalia Kim, Lyudmila Shevchenko, Steve Peigneur, Jan Tytgat, Emma Kozlovskaya, Elena Leychenko
Publikováno v:
Marine Drugs, Vol 17, Iss 10, p 542 (2019)
Sea anemones’ venom is rich in peptides acting on different biological targets, mainly on cytoplasmic membranes and ion channels. These animals are also a source of pancreatic α-amylase inhibitors, which have the ability to control the glucose lev
Externí odkaz:
https://doaj.org/article/71f1ac1df57149ff80b76811bcf6b041