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In Vivo Application of Histone Deacetylase Inhibitor Trichostatin-A Impairs Murine Male Meiosis

Autor: Johannes Trapp, Klaus Failing, Klaus Steger, Felix Thierer, Hamid Hossain, Violetta Sonnack, Martin Bergmann, Kai S Edler, Manfred Jung, Trinad Chakraborty, Irina Fenic, Svetlin Tchatalbachev

Publikováno v: Journal of Andrology. 29:172-185

In vivo application of histone deacetylase (HDAC) inhibitor trichostatin-A (TSA) in mice results in male infertility. To get more insight into the mechanisms underlying this phenomenon, we performed a genome-wide expression analysis and investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b098e609d818da6f9c33e13ce0b873f4
https://doi.org/10.2164/jandrol.107.003848

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Loss of heterozygosity at 12p13 and loss of p27KIP1 protein expression contribute to melanoma progression

Autor: Sebastian Hauser, Joachim Woenckhaus, Christian Woenckhaus, Klaus Failing, Thomas Dittberner, Micaela Poetsch, Jürgen Giebel, Irina Fenic

Publikováno v: Virchows Archiv. 445:491-497

Little is known about the mechanisms causing p27KIP1 decrease in melanomas. Therefore, we performed loss of heterozygosity (LOH) analysis with polymerase chain reaction at seven different loci surrounding the p27KIP1/CDKN1B gene at 12p13 and direct D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c8e622ae85d39213afbcd6fb4ba1de
https://doi.org/10.1007/s00428-004-1049-6

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Expression of AP-2?, c-kit, and cleaved caspase-6 and -3 in naevi and malignant melanomas of the skin. A possible role for caspases in melanoma progression?

Autor: Irina Fenic, Christian Woenckhaus, Micaela Poetsch, Klaus Failing, Thomas Dittberner, Jürgen Giebel

Publikováno v: The Journal of Pathology. 201:278-287

Progression of melanoma is associated with loss of the transcription factor AP-2α and tyrosine-kinase receptor c-kit. However, the mechanisms by which these two proteins are down-regulated have not been fully elucidated. Fifty non-selected melanomas

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https://doi.org/10.1002/path.1424

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Aberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia

Autor: Irina Fenic, Klaus Steger, Klaus Sturm, Lutz Konrad, Wolfgang Weidner, Agnieszka Paradowska, Florian M.E. Wagenlehner

Publikováno v: International Journal of Oncology. 35

Expression of the imprinted genes insulin-like growth factor 2 (IGF2) and H19 depends on the methylation pattern of their common imprinting control region (ICR) located on chromosome 11p15. As the somatic imprinting pattern may be lost during tumorig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6901036856e7babb9d0a1187839241
https://doi.org/10.3892/ijo_00000316

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In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis

Autor: Klaus Steger, Violetta Sonnack, Irina Fenic, Klaus Failing, Martin Bergmann

Publikováno v: Journal of andrology. 25(5)

The acetylation state of core histones is controlled by two classes of enzymes, histone acetyl transferases (HATs) and histone deacetylases (HDACs). HDAC inhibitors, such as trichostatin-A (TSA), are able to induce cell cycle arrest by stimulating tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a13ace5ac13d4a042168c465c1b423
https://pubmed.ncbi.nlm.nih.gov/15292114

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Expression of PTEN in malignant and non-malignant human prostate tissues: comparison with p27 protein expression

Autor: Irina Fenic, Klaus Failing, Folker E. Franke, Joachim Woenckhaus, Klaus Steger

Publikováno v: The Journal of pathology. 203(1)

The role of the putative tumour suppressor PTEN in prostate carcinogenesis is controversial. There are conflicting data regarding the rate of its gene inactivation, the role of transcriptional and post-transcriptional factors, as well as its relation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c179db5781d050f77306aa7a5d1eee1
https://pubmed.ncbi.nlm.nih.gov/15095479

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Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma

Autor: Irina Fenic, Ulrich Stahl, Thomas Dreyer, Eva Werner, Joachim Woenckhaus, Ulrike Gamerdinger, Klaus Steger

Publikováno v: The Journal of pathology. 198(3)

PIK3CA, encoding the catalytic subunit p110α of phosphatidylinositol 3-kinase (PI3K), is activated in malignant diseases. However, the role of the PIK3CA gene aberrations for tumourigenesis of head and neck squamous cell carcinoma (HNSCC) is to date

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40768974101c561ef2622a6805310bc
https://pubmed.ncbi.nlm.nih.gov/12375266

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