Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Irina Dobrescu"'
1
Akademický článek
Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum
Autor: Flore Nardella, Irina Dobrescu, Haitham Hassan, Fabien Rodrigues, Sabine Thiberge, Liliana Mancio-Silva, Ambre Tafit, Corinne Jallet, Véronique Cadet-Daniel, Stéphane Goussin, Audrey Lorthiois, Yoann Menon, Nicolas Molinier, Dany Pechalrieu, Christophe Long, François Sautel, Mariette Matondo, Magalie Duchateau, Guillaume Médard, Benoit Witkowski, Artur Scherf, Ludovic Halby, Paola B. Arimondo
Publikováno v: iScience, Vol 26, Iss 2, Pp 105940- (2023)
Summary: Malaria eradication requires the development of new drugs to combat drug-resistant parasites. We identified bisbenzylisoquinoline alkaloids isolated from Cocculus hirsutus that are active against Plasmodium falciparum blood stages. Synthesis
Externí odkaz: https://doaj.org/article/f12af47207ad40a38e61010f2bc8e9c9
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2
Akademický článek
São Paulo School of Advanced Sciences on Vaccines: an overview
Autor: Sara Sorgi, Vivian Bonezi, Mariana R. Dominguez, Alba Marina Gimenez, Irina Dobrescu, Silvia Boscardin, Helder I. Nakaya, Daniel Y. Bargieri, Irene S. Soares, Eduardo L. V. Silveira
Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)
Abstract Two years ago, we held an exciting event entitled the São Paulo School of Advanced Sciences on Vaccines (SPSASV). Sixty-eight Ph.D. students, postdoctoral fellows and independent researchers from 37 different countries met at the Mendes Pla
Externí odkaz: https://doaj.org/article/ac7a25fd4eb74244a022e52fd0000f1b
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3
Akademický článek
Protective Immunity in Mice Immunized With P. vivax MSP119-Based Formulations and Challenged With P. berghei Expressing PvMSP119
Autor: Irina Dobrescu, Tarsila Mendes de Camargo, Alba Marina Gimenez, Oscar Murillo, Kelly Nazaré da Silva Amorim, Claudio Romero Farias Marinho, Irene Silva Soares, Silvia Beatriz Boscardin, Daniel Youssef Bargieri
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
The lack of continuous in vitro cultures has been an obstacle delaying pre-clinical testing of Plasmodium vivax vaccine formulations based on known antigens. In this study, we generated a model to test available formulations based on the P. vivax MSP
Externí odkaz: https://doaj.org/article/1f5af45c58e64fc5a7eb1fadd50b4107
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4
Akademický článek
ZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver‐stage development
Autor: Tejram Sahu, Bertrand Boisson, Céline Lacroix, Emmanuel Bischoff, Quentin Richier, Pauline Formaglio, Sabine Thiberge, Irina Dobrescu, Robert Ménard, Patricia Baldacci
Publikováno v: EMBO Molecular Medicine, Vol 6, Iss 11, Pp 1387-1397 (2014)
Abstract The malaria parasite, Plasmodium, requires iron for growth, but how it imports iron remains unknown. We characterize here a protein that belongs to the ZIP (Zrt‐, Irt‐like Protein) family of metal ion transport proteins and have named ZI
Externí odkaz: https://doaj.org/article/fa059ac813c341449c3fd7b0de0ddfce
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7
Quinazoline-quinoline bisubstrate inhibitors target eukaryotic translation initiation factor 3 inPlasmodium falciparum
Autor: Irina Dobrescu, Elie Hammam, Jerzy M. Dziekan, Aurélie Claës, Ludovic Halby, Peter Preiser, Zbynek Bozdech, Paola B. Arimondo, Artur Scherf, Flore Nardella
Malaria drug resistance is hampering the fight against the deadliest parasitic disease affecting over 200 million people worldwide. We recently developed quinoline-quinazoline-based inhibitors (as compound70) as promising new antimalarials. Here we a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a5914a9be3e5e0b6b87843c606f2fef
https://doi.org/10.1101/2022.12.10.519887
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9
Procainamide-SAHA fused inhibitors of hHDAC6 tackle multi-drug resistant malaria parasites
Autor: Elie Hammam, Roger Peronet, Artur Scherf, Salah Mecheri, Camille Roesch, Ludovic Halby, Corentin Bon, Irina Dobrescu, Ambre Tafit, Paola B. Arimondo, Aurélie Claes, Diane Erdmann, Johanna Viluma, Véronique Cadet-Daniel, Melissa Mairet-Khedim, Benoit Witkowski, Flore Nardella
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2021, 64 (14), pp.10403-10417. ⟨10.1021/acs.jmedchem.1c00821⟩
Journal of Medicinal Chemistry, American Chemical Society, In press, ⟨10.1021/acs.jmedchem.1c00821⟩
International audience; Epigenetic post-translational modifications are essential for human malaria parasite survival and progression through its life cycle. Here, we present new functionalized suberoylanilide hydroxamic acid (SAHA) derivatives that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f5613d6b100c6ac0566df4786f8d56
https://hal.science/hal-03264653/document
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10
São Paulo School of Advanced Sciences on Vaccines: an overview
Autor: Eduardo Lani Volpe da Silveira, Irene da Silva Soares, Vivian Bonezi, Helder I. Nakaya, Mariana R. Dominguez, Silvia Beatriz Boscardin, Irina Dobrescu, Sara Sorgi, Daniel Y. Bargieri, Alba Marina Gimenez
Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 26, Article number: e20190061, Published: 06 APR 2020
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Journal of Venomous Animals and Toxins including Tropical Diseases v.26 2020
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
The Journal of Venomous Animals and Toxins Including Tropical Diseases
Two years ago, we held an exciting event entitled the São Paulo School of Advanced Sciences on Vaccines (SPSASV). Sixty-eight Ph.D. students, postdoctoral fellows and independent researchers from 37 different countries met at the Mendes Plaza Hotel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05334705cb2a131c19956bd90c6bc029
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100201&lng=en&tlng=en
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