Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Irina Culminskaya"'
Autor:
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Yury Loika, Elena Loiko, Irina Culminskaya
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION The variability in apolipoprotein E (APOE) ε4‐attributed susceptibility to Alzheimer's disease (AD) across ancestries, sexes, and ages may stem from the modulating effects of other genetic variants. METHODS We examined associ
Externí odkaz:
https://doaj.org/article/f942fc4def444aaf801aad1a51aec5af
Autor:
Alexander M. Kulminski, Leonardo Shu, Yury Loika, Liang He, Alireza Nazarian, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, Irina Culminskaya
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Apolipoprotein E (APOE) ε2 and ε4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro “risk” factors for Alzheimer's disease (AD). Methods We examined differences in linkage dise
Externí odkaz:
https://doaj.org/article/f05849ada38a4a9b97436d5ad301e47c
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction As a multifactorial polygenic disorder, Alzheimer's disease (AD) can be associated with complex haplotypes or compound genotypes. Methods We examined associations of 4960 single nucleotide polymorphism (SNP) triples, comprising
Externí odkaz:
https://doaj.org/article/204760467c9a4268896f1487ce7e27e4
Autor:
Alexander M. Kulminski, Yury Loika, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Svetlana Ukraintseva, Anatoliy I. Yashin, Irina Culminskaya
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Age-related phenotypes are characterized by genetic heterogeneity attributed to an uncertain role of evolution in establishing their molecular mechanisms. Here, we performed univariate and pleiotropic meta-analyses of 24 age-related phenotypes dealin
Externí odkaz:
https://doaj.org/article/1168208983384b4b9c23c23a9ca47ba6
Autor:
Alexander M Kulminski, Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G Arbeev, Elena Loiko, Liubov Arbeeva, Olivia Bagley, Matt Duan, Arseniy Yashkin, Fang Fang, Mikhail Kovtun, Svetlana V Ukraintseva, Deqing Wu, Anatoliy I Yashin
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006314 (2016)
Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these phenotypes. To gain more insights, we combined methods of genome-wide and candidate-gene stu
Externí odkaz:
https://doaj.org/article/4119000c967b4da88792985d10b82e1a
Autor:
Alexander M Kulminski, Irina Culminskaya, Konstantin G Arbeev, Liubov Arbeeva, Svetlana V Ukraintseva, Eric Stallard, Deqing Wu, Anatoliy I Yashin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136319 (2015)
Insights into genetic origin of diseases and related traits could substantially impact strategies for improving human health. The results of genome-wide association studies (GWAS) are often positioned as discoveries of unconditional risk alleles of c
Externí odkaz:
https://doaj.org/article/784f72dffd714b2497ce9fd77a9121c3
Autor:
Alexander M Kulminski, Konstantin G Arbeev, Irina Culminskaya, Liubov Arbeeva, Svetlana V Ukraintseva, Eric Stallard, Kaare Christensen, Nicole Schupf, Michael A Province, Anatoli I Yashin
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004141 (2014)
Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed populations from the Framin
Externí odkaz:
https://doaj.org/article/5d494ba236074122986ea756b20368b0
Autor:
Anatoli I. Yashin, Konstantin G. Arbeev, Igor Akushevich, Liubov Arbeeva, Julia Kravchenko, Dora Il'yasova, Alexander Kulminski, Lucy Akushevich, Irina Culminskaya, Deqing Wu, Svetlana V. Ukraintseva
Publikováno v:
Current Gerontology and Geriatrics Research, Vol 2010 (2010)
It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks. Studies of connection between aging and life span suggest a possibility that dynamic properties
Externí odkaz:
https://doaj.org/article/ba457b04dd544ac9879dafee06994d23
Publikováno v:
GeroScience. 45:233-247
The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer’s disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c7d5723c66a15d87eb65920ff37008
https://doi.org/10.1007/s11357-022-00617-0
https://doi.org/10.1007/s11357-022-00617-0
Publikováno v:
GeroScience
Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer’s disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25e9d937f1d3ac41d117807423aa20b
http://europepmc.org/articles/PMC8572080
http://europepmc.org/articles/PMC8572080